ArtikelThe Evolution of Phosphite‐Oxazoline Ligands for the Pd‐Allylic Substitution and Their Application in Building Chiral Moleculesvon Maria Biosca et al. · 21.09.2023 This concept provides an overview of the evolution in the ligand design of biaryl phosphite-oxazoline ligand libraries for the asymmetric Pd-catalyzed allylic substitution. In addition, the effectiveness of this approach in the construction of chira...
ArtikelPyramidalization at the sp2‐Hybridized ipso‐Carbon Atom of Phenyl Compoundsvon Henri Brunner et al. · 21.09.2023 In toluene, ethylbenzene, and t-butylbenzene the sp2-hybridized center at the ipso-carbon atom of the phenyl ring is pyramidalizing on rotation about the bond phenyl-substituent. A comparison of structures with pyramidalization and its hypothetical ...
ArtikelMetal‐Free Visible Light‐Promoted Synthesis of 1,2,2‐Triarylethanones and 2,2‐Diarylethanones: Route Towards Tamoxifenvon Zhiqiang Zhu et al. · 21.09.2023 An efficient and straightforward methodology for the synthesis of 1,2,2-triarylethanones and 2,2-diarylethanones has been developed, via a visible light-promoted/Brønsted acid-catalyzed carbonyl-alkyne metathesis/transfer hydrogenation one-pot react...
ArtikelMulticomponent and Metal‐Free Diels–Alder/Aromatization Approach to the Stereospecific Synthesis of E‐(Hetero)Stilbenes and Diarylacetylenesvon Marco Ballarotto et al. · 21.09.2023 A straightforward, stereospecific and regioselective strategy for the synthesis of substituted E-stilbenes and diarylacetylenes without the use of metal catalysts was developed. DFT calculations were also performed confirming a concerted [4+2] react...
ArtikelSynthesis of Flavones through NaI‐Mediated Electrochemical Cyclization of Chalconesvon Taweesak Gulchatchai et al. · 21.09.2023 In this work, we demonstrated a novel electrochemical oxidative cyclization for synthesis of flavone from 2’-hydroxychalcone using an inexpensive using low toxic NaI as mediator/electrolyte without external additives in EtOH/water solvent. The key f...
ArtikelPalladium‐Catalyzed Asymmetric Trifluoromethylated Allylic Alkylation of N‐Substituted Glycine Ethyl Esters with α‐(Trifluoromethyl)alkenyl Acetatesvon Shuaibo Zhang et al. · 21.09.2023 An efficient enantioselective palladium-catalyzed trifluoromethylated allylic alkylation of N-substituted glycine ethyl esters using α-(trifluoromethyl)alkenyl acetates as trifluoromethyl-containing allyl precursors is established. A series of optic...
ArtikelVisible‐Light‐Driven Three‐Component Reaction of Unactivated Alkenes Enables Access to Monofluoro γ‐Amino Acidsvon Guodong Ju et al. · 21.09.2023 A strategy for the synthesis of diverse protected α-monofluoro-γ-amino acid derivatives has been developed. This reaction conveniently and efficiently provides monofluoroamino acid ethyl ester-quinoxaline-2(1H)-one derivatives under mild conditions....
Artikel5'‐O‐(2‐Isopropoxyprop‐2‐yl)‐protected Phosphoramidite Building Blocks in the Liquid Phase Oligonucleotide Synthesisvon Zehong Liang et al. · 21.09.2023 Liquid phase oligonucleotide synthesis calls for improved methodologies. We have tested an acetal modification for protection of the 5’-O site of nucleotide building blocks. Good yields were obtained in synthesis of short 2’-deoxyoligonucleotides by...
ArtikelSynthesis of Berkeleylactone A by Ring‐Closing Alkyne Metathesisvon Frank Schmidt et al. · 21.09.2023 Using some straightforward alkyne chemistry and an asymmetric dihydroxylation on a dienoate, the substrate for a ring-closing alkyne metathesis (RCAM) was assembled in a few steps. After semihydrogenation of the triple bond, the resulting macrolacto...
ArtikelOrganophotocatalyzed Synthesis of Vinyl‐SCF3 and Benzoyl‐SCF3 Using a New N‐(SCF3)(CF3)‐Shelf‐Stable Reagentvon Yi Yang et al. · 21.09.2023 The unprecedented use of PhPhN(SCF3)(CF3) as an efficient reagent for the formation of C−SCF3 bond under photoredox conditions is reported. The organophotocatalyst could be used in conjunction with bromine as an activator or in the presence of FAT c...
ArtikelSynthesis and Chiroptical Properties of Binaphthyl‐Hinged [5]Helicenesvon Masashi Hasegawa et al. · 21.09.2023 A novel [5]helicene linked by binaphthyl was prepared as a chiroptical dye exhibiting circularly polarized luminescence. The rigid [5]helicene exhibits higher g lum values (6.0–6.8×10−3) than unlocked helicenes. This is attributed to the C 2 structu...
ArtikelCatalytic Hydrosilylation of Imines by Aluminum Hydride Cationsvon Mamta Bhandari et al. · 21.09.2023 A wide range of imines were hydrosilylated with a variety of silanes under the catalytic potential of electronically unsaturated cationic aluminum hydrides. Imines were activated by the cationic Al hydrides via the Lewis adduct formation and subsequ...
ArtikelDioxygen‐Triggered β‐Hydroxysulfonylation of Terminal Olefins Controlled by DABCOvon Hang Gong et al. · 21.09.2023 We herein described a dioxygen-triggered β-hydroxysulfonylation of unactivated olefins. The selectivity of the reaction is controlled by DABCO, which acts as a single electron transfer reagent in the reaction. This strategy has the advantages of bei...
ArtikelMolecular Turnstiles Featuring Bicyclic Rotators: Solution and Solid‐State Investigation of Steric and Electronic Concernsvon Megan L. et al. · 21.09.2023 Bicyclic rotators connected to rigid stators provide opportunities to study rotational movement via 1H NMR, X-ray crystallography, and UV–vis spectroscopy. Solution studies suggest rotation or wobbling of the central arene with respect to the rigid ...
Artikel2‐Ketophenyl Assisted Biomimetic Synthesis of 3‐Thio Substituted Glycals at Room Temperaturevon Irshad Ahmad et al. · 21.09.2023 In this work, we have described a synthesis of 3-thiosugars stereoselectively from 2-ketoglycals via regioselective displacement of C3 ester group with inversion of configuration. This strategy tolerates well with a variety of substituted thiophenol...
ArtikelFront Cover: The Evolution of Phosphite‐Oxazoline Ligands for the Pd‐Allylic Substitution and Their Application in Building Chiral Molecules (Eur. J. Org. Chem. 36/2023)von Maria Biosca et al. · 21.09.2023 The Front Cover illustrates the designed biaryl phosphite-oxazoline ligand libraries by our group for the asymmetric Pd-catalyzed allylic substitution through the years, highlighting the best family of ligands discovered, along with a diverse array ...
ArtikelJulia‐Kocienski Olefination in the Synthesis of Trisubstituted Alkenes: Recent Progressvon Konstantinos A. et al. · 21.09.2023 Julia-Kocienski olefination has been lately often used in the preparation of trisubstituted alkenes which serve as precursors of natural products and their analogs as well of pharmaceutically interesting/biologically important compounds. Significant...
ArtikelPalladium‐Catalyzed Regioselective C‐H Oxidative Arylation of 7‐Azaindazole N‐Oxide at the C6 Position
ArtikelMagnetic Circularly Polarized Luminescence of Organic Compoundsvon Francesco Zinna et al. · 22.09.2023 The Front Cover shows the emission of circularly polarized light from organic compounds under a magnetic field. This phenomenon, called magnetic circularly polarized luminescence (MCPL) is observed due to the action of the magnetic field itself on t...
ArtikelCu−NHC Complex for Chan‐Evans‐Lam Cross‐Coupling Reactions of N‐Heterocyclic Compounds and Arylboronic Acidsvon Bhupendra Adhikari et al. · 22.09.2023 An efficient copper(II) N-heterocyclic carbene (NHC) complex catalyzing the Chan–Evans-Lam cross-coupling reaction of N-heterocyclic nucleophiles with arylboronic acid has been explored. This air-stable copper catalyst shows practical robustness tha...
ArtikelAsymmetric Reductive Amination in Organocatalysis and Biocatalysisvon Tingting Li et al. · 22.09.2023 The Cover Feature depicts the iconic main building of Jiangsu Ocean University. The foundation represents the substrate, while the intermediary levels symbolize the presence of reducing agents. The pinnacle of the building signifies the resulting pr...
ArtikelDivergent Total Syntheses of 2, 6‐Dioxabicyclo[3.3.1]nonan‐3‐one Styryllactones: (−)‐Goniopypyrone, (+)‐Goniochelienlactone and (+)‐7‐Acetylgoniochelienlactonevon Yuxin Cui et al. · 22.09.2023 The stereoselective syntheses of three 2,6-dioxabicyclo[3.3.1]nonan-3-one styryllactones, goniopypyrone, goniochelienlactone and 7-acetylgoniochelienlactone, has been accomplished based on chiron approach. In particular, (+)-goniochelienlactone and ...
ArtikelEfficient Synthesis and Microwave‐Assisted Sonogashira Reactions of Triflate‐Substituted Porphyrin
ArtikelOne‐Carbon Homologation of α,β‐Unsaturated Aldehydes: Access to α‐Tertiary β,γ‐Unsaturated Aldehydesvon Arnaud Delbrassinne et al. · 21.09.2023 An efficient two-step no purification protocol for the synthesis of enolizable α-subtituted β,γ-unsaturated aldehydes is reported. The developed strategy involves two steps, epoxidation and Meinwald rearrangement, to result in a formal one-carbon ho...
ArtikelDFT Calculations and Synthesis Reveal: Key Intermediates, Omitted Mechanisms, and Unsymmetrical Bimane Productsvon Bat‐El Oded et al. · 20.09.2023 We studied the mechanism behind the formation of fluorescent syn-bimane. This work combines theoretical and experimental approaches. Our computational study supports Kosower's mechanism while introducing a crucial diaziridine intermediate. Our resul...
ArtikelMeta‐Ortho Effect on the Excited State Pathways of Chloroanilinesvon Cristina Nitu et al. · 20.09.2023 Computational chemistry allows to elucidate the observed selectivity in the photochemistry of chloroanilines. A meta-ortho effect of the substituents favours the population of the prefulvenic conical intersection which leads to rapid deactivation of...
ArtikelThree Component Synthesis of 4‐Aryl‐2‐aminothiazoles under Transition‐Metal Free Conditionsvon Xi Cheng et al. · 20.09.2023 An efficient three-component synthesis of disubstituted 4-aryl-2-aminothiazoles was reported. The protocol features transition-metal free, short reaction time, easily available starting materials, good yields and broad substrates scope, showing pote...
ArtikelPractical Synthesis of Pharmaceutically Relevant Pyrroles from α,β‐Unsaturated Aldehydes and Phenacyl Azidesvon Lodsna Borkotoky et al. · 20.09.2023 A method for the synthesis of 2-aroyl-5-aryl-pyrroles using phenacyl azide and α,β-unsaturated aldehyde at room temperature has been developed. High yield, atom economy and requirement of economic substrates, reagents and organocatalyst as well as n...
ArtikelRing Transformation of α‐Amino‐β‐oxoesters to δ‐Butyrolactamsvon Daniel Krieger et al. · 20.09.2023 Lactams by Ring Transformation: δ-Butyrolactams with an exocyclic ester moiety in the δ-position were accessed by reduction of cyclic α-azido-β-oxocyclopentane carboxylates with Zn−AcOH. The ring transformation proceeded readily under the conditions...
ArtikelEx‐Situ Generation of Bis(trifluoromethyl)disulfide and Applications to Trifluoromethylthiolation Reactions
ArtikelLight‐Induced Domino and Multicomponent Reactions: How to Reach Molecular Complexity without a Catalystvon Polyssena Renzi et al. · 18.09.2023 Is it possible to build up molecular complexity without the help of a catalyst? Yes, it is! With the suitable starting-materials, a domino or multicomponent reaction can be initiated just turning on the right light. Abstract Achieving high molecul...
ArtikelProtocell Communication through the Eyes of Synthetic Organic Chemistsvon Aina Rebasa‐Vallverdu et al. · 18.09.2023 In this Concept, the bio-derived signal transduction machineries utilised for protocell communication are reviewed and categorised into enzyme cascades, DNA strand displacement, and gene-mediated systems. Future opportunities for synthetic chemists ...
ArtikelMultienzymatic Synthesis of γ‐Lactam Building Blocks from Unsaturated Esters and Hydroxylaminevon Christina Jäger et al. · 18.09.2023 N-hydroxy-γ-lactams are produced through an enzymatic sequence combining a lipase-catalyzed hydroxylamidation with an oxidase/peroxidase-induced ene-type cyclization. This methodology provides a mild and scalable access to N-heterocyclic building bl...
ArtikelChiral Lewis Base‐Catalysed Asymmetric Syntheses of Benzo‐fused ϵ‐Lactonesvon Lotte Stockhammer et al. · 18.09.2023 An asymmetric protocol for the synthesis of novel benzofused ϵ-lactones starting from quinone methides and activated acetic acid esters using chiral isothiourea Lewis base catalysts has been developed. Abstract We herein report a two-step protocol...
ArtikelEfficient Solution Phase Synthesis of PPII Helix Mimicking Ena/VASP EVH1 Inhibitors from Proline‐Derived Modules (ProMs)von Dominik Albat et al. · 18.09.2023 In the search for efficient inhibitors for the enabled/vasodilator-stimulated phosphoprotein homology 1 (EVH1) domain to reduce cell motility in metastatic cancer, we previously developed a toolkit of proline-derived modules (ProMs), which mimic the...
ArtikelFirst Asymmetric Total Synthesis of Salinosporamides D and I Using Memory of Chirality and Dynamic Kinetic Resolutionvon Soojun Park et al. · 18.09.2023 Described herein are the total syntheses of salinosporamides via a strategy involving rapid construction of the pyrrolidinone core of the natural products from the simple amino acid serine. The key to the success of this synthesis was the stereosele...
ArtikelOne‐Pot Catalytic Synthesis of Optically Active Drug (S)‐Clopidogrelvon Vincenzo Battaglia et al. · 18.09.2023 A three-step four reactions innovative asymmetric synthesis of popular antiplatelet drug (S)-clopidogrel, marketed as Plavix, has been developed. The telescoped approach relies on the use of a sole organocatalyst, commercially available reagents and...
ArtikelDirect Access to 1,3‐Oxathiolan‐5‐ones via (3+2)‐Cycloaddition of Thioketones and Acetylenedicarboxylic Acid
ArtikelPalladium‐Catalyzed [4+2] Cycloaddition of Vinyl Benzoxazinanones with 1,3‐Indanedione: Approach to Spiro‐Tetrahydroquinoline Scaffoldsvon Qinglang Wei et al. · 15.09.2023 A palladium catalyzed decarboxylative [4+2] cycloaddition of vinyl benzoxazinanones with 1,3-indanedione was developed, affording a series of biologically potential spiro-tetrahydroquinolines. Gram-scale synthesis and product elaboration demonstrate...
ArtikelSynthetic Routes to Imidates and Their Applications in Organic Transformation: Recent Progressvon Andriani G. et al. · 14.09.2023 Imidates are important organic intermediates used in several synthetic transformations towards N-heterocycles, natural products and metal complexes with a potential catalytic effect. Herein, the recent synthetic approaches and diverse applications o...
ArtikelDiastereoselective Dearomatization of Chalcone‐Based Quinolinium Salts to Assemble Bridged Quinobenzazepine Polycycles
ArtikelStereoselective Synthesis of Iminosugar‐C‐Glycosides through Addition of Organometallic Reagents to N‐tert‐Butanesulfinyl Glycosylamines: A Comprehensive Studyvon Daniel Kamzol et al. · 13.09.2023 A comprehensive study of the preparation and reactivity of N-tert-butanesulfinyl glycosylamines with simple Grignard and organo lithium reagents is reported. As they readily react as latent imine equivalents with a variety of carbon nucleophiles in ...
ArtikelLewis Acid Catalysed Chemoselective Amination of Alcohols Using Heterocyclic Thiones: An Avenue to Thiotetrazole Derivativesvon Sudhamoyee Kataky et al. · 13.09.2023 Herein, the development of a Cu(OTf)2 catalysed chemoselective amination of alcohols using heterocyclic thiones is described. Notably, the method is additive, ligand or inert atmosphere free and shows good tolerance towards variety of alcohols and t...
ArtikelC,N‐Diarylformamidines as Valuable Building Blocks in the Synthesis of Heterocyclic Compoundsvon Yulia A. et al. · 12.09.2023 This review is devoted to the heterocyclization of C,N-diarylformamidines and covers publications from 1999 to 2022. The comprehensive information collected enables other researchers to quickly understand the possibility of constructing various comp...
ArtikelPPh3‐Mediated Nucleophilic Sulfonation of Sulfonyl Chlorides with Arynes: Access to Manifold Aryl Sulfonesvon Hui‐Qi Yue et al. · 12.09.2023 A novel PPh3-mediated nucleophilic sulfonation of sulfonyl chlorides with arynes has been demonstrated. This protocol exhibits broad functional group tolerance and provides a direct approach to a variety of aryl and alkyl sulfones. Abstract Sulfon...
ArtikelSynthesis of a N‐heterocyclic Olefin‐Ligated Pd complex [(NHO)Pd{[2‐(CH3O)C6H4]3P}Cl2] as a Catalyst for Suzuki‐Miyaura Coupling
ArtikelCross‐Electrophile Coupling between Two Different Tosylates Enabled by Nickel/Palladium Cooperative Catalysis
ArtikelVisible‐Light‐Driven Synthesis of Phenanthridin‐6(5H)‐one and N‐Substituted Carbazole Derivatives through Intramolecular C‐H Arylationvon Micaela Ayelén et al. · 11.09.2023 The synthesis of phenanthridinones and carbazoles by intramolecular photo- and Base-promoted Homolityc Aromatic Substitution photo-BHAS) reaction from N-(2-halobenzyl)-N-methylanilines or N-substituted-N-phenyl anilines is presented. The synthetic p...
ArtikelTumor Carbohydrate Associated Antigen Analogs as Potential Binders for Siglec‐7von Cristina Di et al. · 11.09.2023 The binding recognition of two structurally constrained sialyl derivatives by Siglec-7was investigated. The flexibility of Siglec-7 loops allowed the preferred accommodation of the more rigid compound containing a biphenyl moiety. Our results set th...
ArtikelFacile Stereoselective Synthesis and Structural Study of Camphor and Fenchone Based Spirocyclic 1,3,4‐Oxadiazolines
ArtikelDistinct Heterocyclic Moieties Govern the Selectivity of Thiophene‐Vinylene‐Based Ligands Towards Aβ or Tau Pathology in Alzheimer´s Disease
ArtikelEnantiospecific Total Synthesis of (–)‐Hyacinthacine A1 and (+)‐Hyacinthacine A1 and their Homologues Using Nitrogen Substituted Donor‐Acceptor Cyclopropane
ArtikelDiaminocyclopentadienone Ruthenium Complex Catalyzed Alkylation of Indoles and Ketones with Primary Alcohols
ArtikelMonofluoromethylation of Cyclic Sulfamidates and Sulfates with α‐Fluorocarbanions of Fluorobis(phenylsulfonyl)methane and Ethyl 2‐Fluoroacetoacetatevon Jun‐Liang Zeng et al. · 08.09.2023 The ring-opening of cyclic sulfamidates and sulfates with α-fluorocarbanion generated from fluorobis(phenylsulfonyl)methane (FBSM) and subsequent reductive desulfonylation have been developed. This fluoromethylation approach allows access to γ- and ...
ArtikelElectrochemical Sulphenylation/Cyclization of Quinones: A Rapid, Green, and Efficient Access to Cytotoxic Compoundsvon Emilay B. et al. · 08.09.2023 Undivided electrochemical cells were utilized for sulphenylation reactions to prepare sulphur-containing naphthoquinones with potent bioactivity. Abstract Undivided electrochemical cells enable economical preparation of sulphur-containing naphthoq...
ArtikelTrichloromethylative Olefin Lactonization by Photoredox Catalysisvon Shinji Harada et al. · 08.09.2023 Trichloromethylative olefin lactonization was reported. A photoredox iridium catalyst irradiated with blue LEDs promoted the reaction without using hazardous reagents. The mechanistic studies were performed by experimental and theoretical means. The...
ArtikelUse of Formic Acid as a CO Surrogate for the Reduction of Nitroarenes in the Presence of Dienes: A Two‐Step Synthesis of N‐Arylpyrroles via 1,2‐Oxazinesvon Manar Ahmed et al. · 08.09.2023 Formic acid was employed as a CO surrogate to deoxygenate nitroarenes to nitrosoarenes, a reaction catalyzed by a palladium/phenanthroline complex. Nitrosoarenes, trapped by conjugated dienes, afforded 3,6-dihydro-2H-[1,2]-oxazines. The latter were ...
ArtikelAnnulation via Ring Opening/Cyclization of Donor‐Acceptor Cyclobutanes with 2‐Naphthols: Access to Highly Functionalized Naphthalene‐Fused Oxepinesvon Yongshun Wen et al. · 08.09.2023 In this work, a mild and straightforward access to various substituted naphthalene-fused oxepines from readily available Donor-Acceptor (D-A) cyclobutanes and 2-naphthols is reported. A broad range of functional groups is tolerated during this trans...
ArtikelAzodicarboxylate‐Mediated Peptide Cyclisation: Application to Disulfide Bond Formation in Solution and Solid Phasevon Alexandra R. et al. · 08.09.2023 Herein, the application of diethylazodicarboxylate as an efficient and highly chemoselective oxidising reagent for the cyclisation of peptides through a disulfide bond is demonstrated. The scope of this application was demonstrated both in solution ...
ArtikelBF3 ⋅ Et2O‐Mediated Annulation of 2‐Alkynyl Biaryls with N‐(Arylthio) Succinimides: An Efficient Approach to Access 9‐Sulfenylphenanthrenesvon Haoru Jin et al. · 07.09.2023 A simple and effective method for the synthesis of 9-sulfenylphenanthrenes was developed. The reaction proceeds through BF3 ⋅ OEt2-mediated annulation of 2-alkynyl biaryls with N-arylthio succinimides at room temperature. With this method, a series ...
ArtikelSolvent Directed Diastereodivergent Synthesis of Spiro‐Oxindoles with Quaternary Carbon Center Formingvon Yang Zhang et al. · 07.09.2023 An efficient method has been developed to achieve solvent-directed diastereodivergent cyclization reactions with quaternary center formation. A series of products were obtained with good yields and diastereoselectivities. Abstract An efficient met...
ArtikelPd‐Catalyzed [3+2]‐Dehydrogenative Annulation Reactionsvon Yang Liu et al. · 07.09.2023 Pd-catalyzed [3+2] annulations go dehydrogenative: a new protocol enables the Pd(II)-catalyzed [3+2] annulation between resonance-stabilized acetamides (or 3-oxoglutarates) and β,γ-unsaturated cyclic carbonyl derivatives. This dehydrogenative strate...
ArtikelEnantioselective Construction of Axially Iodobenzocarbazole Derivatives via Stereogenic‐at‐cobalt(III)‐complex‐catalyzed Iodoarylation of Alkynes
ArtikelSynthesis of Indenes via Graphene Oxide Mediated Manipulation of Morita‐Baylis‐Hillman Alcoholsvon Sebastiano Mantovani et al. · 06.09.2023 Carbocatalysis expands its applicability to the synthesis of indenes via intramolecular Friedel-Crafts like alkylation of Morita-Baylis-Hilman alcohols. Graphene oxide (GO) dictated the conditions to document a C−C bond forming protocol featuring la...
ArtikelEpimerization of trans‐Cycloalkenes with the X–C=C–SeR*‐Unit – The Steric Demand of X = H, F, Cl, Br, I, Me, Et and CF3
ArtikelPlus‐Size DiPAMP Hybrids for Advanced Rhodium(I)‐Catalyzed Hydrogenation: The 2RBigFUS Modelvon Barbara Mohar et al. · 06.09.2023 Multipurpose hydrogenation catalysts, endowed with a top-performance under economical conditions, is the outcome of Knowles’ DiPAMP evolved version. Bulky rather than super-thin Ligand models seem to fit better for a broader scope of Rh(I)-L catalys...
ArtikelMetal‐Free and Visible Light‐Induced Difunctionalizations of α‐CF3 Styrenes with Aryl Diazonium Salts and Hetero Nucleophiles
ArtikelA Dual Photoredox‐ and Cp2TiCl2‐Catalyzed Approach for the Direct Access to α‐Vinyl‐β‐hydroxy Estersvon Emanuele Pinosa et al. · 04.09.2023 A novel dual visible-light-photoredox- and titanocene-catalyzed protocol for the highly regioselective access to α-vinyl, β-hydroxy esters is reported. Thanks to a comprehensive investigation on the reaction conditions, the disclosure of an original...
ArtikelChemical Upcycling of Polyolefins through C−H Functionalizationvon Yinsong Zhao et al. · 04.09.2023 This review summarizes the latest excellent achievements on chemical upcycling of polyolefins through C−H functionalization including the installations of C−C and C−X (X=O, N, S, halogens and etc.) bonds onto polymer backbones to form newly-function...
ArtikelDirect Trifluoromethylselenolation and Fluoroalkylselenolation of C−H Bonds: Recent Advances in Reagents Development and Reactionsvon Yan Gao et al. · 04.09.2023 This review provides an overview of recent advances in direct C−H trifluoromethylselenolation and fluoroalkylselenolation from development to the application of corresponding reagents. Abstract Due to their high lipophilicity and strong electron-w...
ArtikelA Fluorescent Probe for Al3+ Based on Calix[4]arene Containing Salicylaldehyde‐Derived Schiff Basevon Zuquan Wang et al. · 04.09.2023 A novel fluorescent probe was designed and synthesized by functionalizing the upper edge of calix[4]arenes with salicylaldehyde-derived Schiff-bases. This probe could recognize Al3+ with high selectivity and “on” fluorescence response. Abstract Tw...
ArtikelFormal Radical Deoxyfluorination of Oxalate‐activated Alcohols triggered by the Selectfluor‐DMAP Charge‐Transfer Complex
ArtikelHBTU Mediated Synthesis of α,β‐Unsaturated γ‐Lactams from E‐α,β‐Unsaturated γ‐Amino Acidsvon Manjeet Singh et al. · 01.09.2023 The direct transformation of N-protected α,β-unsaturated γ-amino acids into corresponding α,β-unsaturated γ-lactams through in situ activation of carboxylic acid using the peptide coupling agent HBTU in the presence of base DIPEA is reported. The tr...
ArtikelAmination of Isonitriles in Water: Urea Synthesis under Biocompatible Conditionsvon Qi Zhang et al. · 31.08.2023 Biocompatible ligation of isonitriles and amines to ureas in neutral aqueous medium was developed here. Direct labeling of Ac4GlcN has been achieved in Hep G2 cells, which may be used to diagnose proteins with abnormal expression in their native hab...
ArtikelVisible‐Light‐Mediated Synthesis of Bicalutamide by Regioselective Hydroxysulfonylation of Acrylamidesvon Mercedes Zurro et al. · 31.08.2023 Synthesis of anticancer drug bicalutamide promoted by visible light in one step from the corresponding N-arylacrylamide is described. This approach involves a one-pot hydroxysulfonylation reaction through a photocatalytic redox process. The use of N...
ArtikelPotassium Persulfate‐Glucose Mediated Synthesis of (3)‐S‐Arylthioindoles from Indole and Thiophenols in Watervon Nitin Kumar et al. · 31.08.2023 Synthesis of functionalized 3-(S)-arylthioindoles was achieved from indoles and aryl thiols. The coupling reaction was performed in water in the presence of K2S2O8 and glucose at room temperature. Abstract An efficient and eco-friendly method has ...
ArtikelCatalyst‐Free [3+2] Cycloaddition of Isoquinolinium/Pyridinium Ylides and Electron‐Deficient Alkenesvon Xueting Zhou et al. · 31.08.2023 A mild and operationally simple one-pot protocol for the [3+2] cycloaddition of isoquinolinium/pyridinium ylides and electron-deficient alkenes using NaBH3CN as reductant has been developed. A series of pyrrolo[2,1-a]isoquinolines and pyrrolo[3,4-a]...
ArtikelPhotocatalytic C−H Functionalization of Nitrogen Heterocycles Mediated by a Redox Active Protecting Groupvon Marianela G. et al. · 31.08.2023 Herein, we report a photocatalytic strategy to efficiently access functionalized azaheterocycles starting from one equivalent of an heterocyclic precursor incorporating a redox active benzamide protecting group. Activation of the protecting group tr...
ArtikelSynthesis of Deuterated and Protiated Triacylglycerides by Using 1,1’‐Carbonyldiimidazole Activated Fatty Acids
ArtikelSulfoxonium Ylides as Carbene Precusors in Rhodium‐Catalyzed Sommelet‐Hauser Rearrangement for the Synthesis of S/Se‐Containing Compounds
ArtikelI2‐DMSO‐Mediated Cascade Cyclization of β‐Ketosulfoxonium Ylides and β‐Enaminones: Synthesis of Quaternary‐Carbon‐Centered 2‐Hydroxy‐pyrrol‐3(2H)‐onesvon Rahul Kumar et al. · 29.08.2023 A novel I2-DMSO-mediated cascade cyclization approach for the synthesis of 2-hydroxy-pyrrol-3(2H)-one scaffold from β-ketosulfoxonium ylides and β-enaminone derivatives has been described. This cascade transformation forms one C−C bond and one C−N b...
ArtikelMechanochemical Suzuki‐Miyaura Cross‐Coupling with Natural Deep Eutectic Solvent as Liquid‐Assisted Grinding Additive: Merging Two Fields for a Greener Strategyvon Emilie Thiery et al. · 29.08.2023 The combination of two green chemical domains: an efficient and sustainable method for Suzuki-Miyaura mechanochemical cross-coupling reaction with NaDES as LAG additive. The synthesis process is fast and does not require ligand or heating. Abstrac...
ArtikelActivation and Deactivation of Benzylic C−H Bonds Guided by Stereoelectronic Effects in Hydrogen Atom Transfer from Amides and Amines to Alkoxyl Radicalsvon Sergio Sisti et al. · 29.08.2023 Kinetic and product studies on hydrogen atom transfer from the benzylic C−H bonds of amides and amines to tert-alkoxyl radicals highlight the important role played by steric and stereoelectronic effects in these reactions. Structural factors that en...
ArtikelEfficient Synthesis of Fully Substituted and Diversely Functionalized Pyrazoles through p‐TSA Catalyzed One‐Pot Condensation of Cyclic β‐Diketones, Arylglyoxals and Arylhydrazones
ArtikelCopper(I)‐Catalyzed Interrupted Click Reaction: Synthesis of 1,4,5‐Trisubstituted 5‐Chloro‐1,2,3‐Triazoles
ArtikelSynthesis of Benzyl Thioethers by C‐S Coupling of Benzylic Trimethylammonium Salts and Sulfonyl Chlorides
ArtikelAir‐Induced Hydroxyphosphorylation of α‐Trifluoromethyl Styrenes with H‐Phosphonates and H‐Phosphine Oxides
ArtikelRhodium‐Catalysed Selective C‐H Allylation of 1H‐Indazoles with Vinylethylene Carbonate: Easily Introducing Allylic Alcohol
ArtikelDesign and Synthesis of Rigid‐featured Tertiary Amine‐derived C2‐Symmetric Chiral Furan‐N,N'‐dioxide Ligands
ArtikelDifluoromethoxylated Ketones as Building Blocks for the Synthesis of Challenging OCF2H‐Bearing N‐Heterocyclesvon Anaïs Loison et al. · 16.08.2023 A straightforward synthesis of nitrogen-containing heterocycles bearing the Emerging Fluorinated Group −OCF2H is herein disclosed. Various difluoromethoxylated pyrazoles, isoxazoles, pyrimidines and indoles were thus quickly and easily obtained. The...
ArtikelInsights into the Self‐Filling Effects of Branched Isopropyl Groups on the Conformational and Supramolecular Properties of Isopropoxyprism[6]arenevon Rocco Del et al. · 10.08.2023 The closed state cuboid D 2-conformation of the isopropoxy-prism[6]arene shows four isopropyl groups folded inside the cavity, to give C−H⋅⋅⋅π interactions and filling the internal void. The cuboid D 2-conformation of PrS[6] iPr is stabilized to...
ArtikelPhotoredox Catalyzed Energy Transfer for Atom Economical Synthesis of O‐Bridged Tricyclo Fused Cyclopropane Derivatives
ArtikelBiotransformations with Imine Reductases: Design of a Practical Process Avoiding an Extractive Work‐Up by Entrapment of Water and Enzymes in an Immobilized Phase
ArtikelCarbofluorination of π‐Bonds and Related Reactions Involving Tandem C−C/C−F Bond Formationvon E. Ali et al. · 11.05.2023 A review on the carbofluorination of π-bonds and related transformations involving tandem C−C/C−F bond forming reactions is presented. The application of electrophilic fluorine and nucleophilic fluoride reagents in this chemistry is described, as we...
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