Fachzeitschriften

European Journal of Organic Chemistry

Artikel

Introduction of Structural Diversity at the C2 Position of Unsaturated Iminosugars through Palladium‐Catalyzed Cross‐Coupling Reactions

von Quentin Joachim et al.

· 28.08.2025

To increase the structural diversity of iminosugars at the C2 position, protected 2-iodoiminoglycals, efficiently synthesized from sugar lactams, are subjected to mild palladium-catalyzed cross-coupling reactions. Successful aminocarbonylation, aryl...

Artikel

Ligand‐Free Copper‐Catalyzed Allenylative CP Coupling of Propargylic Acetates with H‐Phosphine Oxides

von Shaoqing Liu et al.

· 28.08.2025

P Coupling of Propargylic Acetates with H-Phosphine Oxides"/> A ligand-free CuTC-catalyzed allenylative CP coupling reaction of propargylic acetates with H-phosphine oxides to yield allenylphosphine oxides is reported, with scope and mechanism disc...

Artikel

Electrochemical gem‐Bisarylation of Hydrazone: Access to Bis(indolyl)methane

von Hui Meng et al.

· 28.08.2025

An electrochemical organic method for the direct synthesis of bis(indolyl)methane (BIM) derivatives is presented, with the reaction of hydrazones and indoles. This electrochemical approach, characterized by simple and mild reaction conditions, provi...

Artikel

Nitrile N‐Oxide‐Based Fluorescent Probe to Impart Aggregation‐Induced Emission to Alkenes

von Yuki Oku et al.

· 28.08.2025

Fluorescent probes have been used extensively in chemical biology. However, there are a few fluorescence probes that covalently bind to less polar compounds without a catalyst. Herein, the design, synthesis, and click reaction of pyrene-based nitril...

Artikel

Selective Synthesis of Furan‐3(2H)‐one Fused Seven‐, Eight‐, or Nine‐Membered Ring from the Reaction of Diynone and Cyclic β‐Keto Ester

von Chengyang Tian et al.

· 28.08.2025

A domino reaction of diynone and cyclic β-keto ester has been disclosed. This reaction provides a new strategy for the synthesis of a series of furan-3(2H)-one fused seven-, eight-, or nine-membered ring with good stereoselectivity and atom economy....

Artikel

An Efficient Asymmetric Synthesis of Finerenone via Evans’ Chiral Auxiliary

von Safomuddin Abduahadi et al.

· 28.08.2025

The study demonstrates Evans’ (R)-4-benzyl-2-oxazolidinone auxiliary enables efficient asymmetric synthesis of finerenone, achieving stereoselective naphthyridine core construction with 86:14 dr and 80% yield. Subsequent ammonia-mediated transamidat...

Artikel

Photoinduced Cascade Cyclization of Ortho‐Alkynylanilines to Access Dithiocyanated or Selenocyanated Indoles

von Xueli Wang et al.

· 28.08.2025

Diverse indole derivatives are obtained by a cascade process involving dithiocyanation or selenocyanation and cyclization of ortho-alkynylanilines under mild conditions with NH₄SCN/KSeCN. Experiments are undertaken to shed light on the radical react...

Artikel

Metal‐Free HFIP‐Promoted Synthesis of Benzhydryl Derivatives from Stilbenes as Masked Electrophiles under Oxidative Conditions

von Francisco J. et al.

· 28.08.2025

An umpolung strategy allowing the use of stilbenes as electrophiles in substitution reactions is developed that relies on a combination of m-chloroperbenzoic acid and hexafluoroisopropanol. This new step-economic approach gives rise to benzhydryl de...

Artikel

Rhodium‐Catalyzed (3+3) Cascade Cyclization of Diazobarbiturates with 2H‐Azirines for the Diastereoselective Construction of Spirooxazinopyrimidinediones

von Yue Zhang et al.

· 28.08.2025

Under the catalysis of Rh₂(esp)₂ (10 mol%) and BINAP (20 mol%) in 1,2-dichloroethane at 80 °C, a (3+3) cascade cyclization between diazobarbiturates and 2H-azirines proceeds smoothly, yielding spirooxazinopyrimidinediones in 24–92% yield with >20...

Artikel

The Dihydroindeno[2,1‐c]fluorene Core: From Syntheses to Properties and Potential Applications

von Timothée Cadart et al.

· 28.08.2025

In this review, the latest research progress in synthesis and application of variously decorated aromatic compounds possessing the indeno[2.1-c]fluorene scaffold is summarized. In addition to covering synthetic endeavors, their transformation to oth...

Artikel

Organocatalytic Asymmetric Cyclization Reactions with γ‐Hydroxyenones

von Megha Balha et al.

· 28.08.2025

An overview of recent advancements in γ-hydroxyenone-based organocatalytic asymmetric cyclization techniques is given in this review paper. Because γ-hydroxyenones are bifunctional, they are an effective building block for creating oxa-heterocycles....

Artikel

Fluorinated Aminophosphonates and Aminophosphonic Acids: A Journey through Recent Advances

von Tomasz Cytlak et al.

· 28.08.2025

Recent advances in the synthesis of fluorinated aminophosphonates and aminophosphonic acids are highlighted, with particular emphasis on regio-, diastereo-, and enantioselective methods that allow precise introduction of fluorine atoms. This review...

Artikel

Covalent Organic Framework Films: Preparation, Properties, and Applications

von Qinchen Jiang et al.

· 28.08.2025

Covalent organic frameworks (COFs) represent a class of crystalline porous materials that garner significant attention due to their tunable structures and diverse functionalities. This review highlights recent advancements in COF films. It discusses...

Artikel

Photocatalyzed Reduction of β‐Nitroacrylates via Hydrogen Atom Transfer Promoted by Tetrabutylammonium Decatungstate

von Gabriele Lupidi et al.

· 03.09.2025

Tetrabutylammonium decatungstate is hereby applied as efficient photocatalyst for the hydrogenation or deuteration of β-nitroacrylates via hydrogen atom transfer. The protocol affords the desired products in good yields, with short reaction time, an...

Artikel

Green Multicomponent One‐Pot Synthesis of 2‐(2′‐Hydroxyphenyl)Imidazo[1,2‐a]Pyridine Analogs with an Intramolecular Hydrogen‐Bonded Eight‐Membered Ring Exhibiting Excited‐State Intramolecular Proton Transfer Luminescence

von Mahanandaiah Kurva et al.

· 02.09.2025

Sonochemical multicomponent synthesis of 2-(2´-hydroxyphenyl)imidazo[1,2-a]pyridine analogs with an intramolecular hydrogen-bonded eight-membered ring exhibiting an excited-state intramolecular proton transfer fluorescent process. Multicomponent r...

Artikel

Efficient Route for Construction of Fluorinated Isoxazolines through Base‐Mediated Fluorinated Amino Acid Derivatives

von Zhengling Wu et al.

· 01.09.2025

A base-mediated, transition-metal-free reaction between ethyl 3-bromo-2-((diphenylmethylene)amino)-3,3-difluoropropanoate and nitrones facilitates a rapid, one-step synthesis of fluorinated isoxazolidines. This streamlined protocol proceeds under mi...

Artikel

Ruthenium‐Catalyzed Regioselective Sulphonamidation of Benzo[b][1,4]oxazin‐2‐ones via Csp2–H Functionalization Using Sulfonyl Azides

von Riya Chaudhary et al.

· 01.09.2025

A (Ru)-catalyzed ortho-CH sulphonamidation of benzo[b][1,4]oxazin-2-ones using sulfonyl azides enables access to diverse sulphonamides in excellent yields. The method features broad substrate scope, high regio- and chemoselectivity, and functional ...

Artikel

Organocatalytic Halogenation of Aromatic and Heteroaromatic Compounds

von Paola Acosta‐Guzmán et al.

· 30.08.2025

Due to their importance in organic synthesis and the design of drugs and materials containing haloarenes or haloheteroarenes, this review highlights recent advances in their synthesis via organocatalysis. It covers not only classical challenges like...

Artikel

Intramolecular Azide–Alkene Cycloaddition—The Logothetis Reaction

von Douglass F.

· 30.08.2025

As originally reported by Logothetis, alkenyl azides cyclize smoothly on warming, leading, depending on substitution, to cyclic imines or bicyclic aziridines. These intermediates can then be carried on to other products. This review summarizes the m...

Artikel

Hydrogen Peroxide‐Responsive Aminoferrocene Prodrugs

von Marlies Körber et al.

· 29.08.2025

To improve sensitivity toward H₂O₂, the boronic acid pinacol ester in known aminoferrocene-based anticancer prodrug 13b is replaced with an α-ketamide fragment to obtain prodrug 2a and some of its N-alkylated derivatives. 2a exhibits substantially i...

Artikel

Transition Metal‐Free Ortho‐Deuteration of Electron‐Deficient N‐Heteroarenes

von Žiga Oražem et al.

· 28.08.2025

Herin, the metal-free, selective deuteration of electron-deficient N-heteroaromatics is reported using O-carbamate and carboxamide ortho-directing groups (DGs), lithium 2,2,6,6-tetramethylpiperidide as the base, and D₂O as a green source of D⁺. The ...

Artikel

Regiocontrolled Cleavage of Dialkyl Ethers Using Regenerative Borates as a Sustainable Alternative to Boron Trichloride

von Theodora E. et al.

· 28.08.2025

The use of triaryl borates for highly selective ether cleavage is described. The borate is regenerable from the aqueous extract of a previous ether cleavage reaction without repurification, making use of low toxicity boron and phenolic waste. Such s...

Artikel

Fluorescence and Chiroptical Properties of Cyclic Aromatic Triamides with Isolated and Extended Conjugated Systems

von Koji Takagi et al.

· 28.08.2025

Chiroptical properties of cyclic aromatic triamides with isolated and extended conjugated systems are studied to develop promising circularly polarized luminescence (CPL) materials. Cyclic aromatic triamides containing 1,4-bis(phenylethynyl)benzene ...

Artikel

Photocatalyst‐Free, Visible Light‐Induced Hydroalkylation of Vinyl Sulfones with Alcohols

von Branka Krnjaja et al.

· 26.08.2025

This study presents a straightforward, photocatalyst-free method for intermolecular hydroalkylation of vinyl sulfones with alcohols using visible light. Operating under mild conditions without metals or external redox agents, the protocol enables op...

Artikel

Organolanthanum‐Mediated Coupling of 2‐Bromobiaryls with Ester Electrophiles to Access Valuable Biaryl Derivatives

von Yike Bai et al.

· 25.08.2025

Dibenzofulvenes (DBFs) and 9,10-phenanthrenequinones (PQs) are synthesized through a coupling reaction of 2-bromobiaryl compounds with different ester electrophiles by using the unique reactivity of organolanthanum heterocyclic intermediates. This m...

Artikel

Construction of Medium‐Sized Rings Enabled by a Base‐Mediated Ring Expansion Reaction

von Lingmeng Xie et al.

· 25.08.2025

Construction of 8–10 membered rings is achieved via a base-promoted two carbon ring expansion as a general strategy to formally insert a vinyl group to cyclic ketones. Medium-sized ring architectures, widely present in natural products and small mo...

Artikel

Latent‐Functionality‐Based Synthesis of the Furanoside Motif of Hygromycin A

von Yilin Liu et al.

· 25.08.2025

A latent functionality strategy is employed to construct the β-hydroxy ketone motif within the sugar fragment of hygromycin A through the 1,3-dipolar cycloaddition of furan. Facile epimerization at the C5 position enables access to both the natural ...

Artikel

DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids

von Atsushi Umehara et al.

· 25.08.2025

The one-pot direct N-acylation of NH sulsoximines with carboxylic acids is described. The method can be performed under mild low-temperature reaction conditions and exhibits a wide substrate scope (> 60 examples). The present method is operation...

Artikel

Synthesis and Physicochemical Characterization of 6‐Trifluoromethyl Spiro[3.3]Heptane Building Blocks

von Oleksandr S. et al.

· 23.08.2025

Decagram-scale synthesis of functionalized CF₃-containing spiro[3.3]heptane building blocks (including alcohols, amines, boronates, carboxylic acid, and amino acids) starting from the commercially available materials is developed. Using model deriva...

Artikel

Sustainable Synthesis of Biogenic CuO Nanoparticles from Agrowaste for One‐Pot CN Bond Formation

von Partha Pratim et al.

· 23.08.2025

N Bond Formation"/> CuONPs exhibiting excellent catalytic activity are developed following a green and sustainable approach, transforming agrowaste material into wealth. The reusable nanostructure effectively catalyzed the CN bond-forming reactions...

Artikel

[3]Radialene Fluorophores with pH‐Switchable Emission and Stable Absorption Maxima

von Jan P. et al.

· 23.08.2025

The synthesis and characterization of the first push–pull quino [3]radialene fluorophore are reported, integrating a bis(dicyanomethylene)-[3]radialene acceptor with a benzimidazole donor. It exhibits minimal solvatochromism, and vibronic coupling o...

Artikel

Cross‐Coupling Reactions in Aqueous Micellar Media

von Alexander Uner et al.

· 23.08.2025

Aqueous micellar media have emerged as sustainable alternatives to organic solvents for small-molecule synthesis. This Review discusses the evolution of surfactants for synthesis, their application to cross-coupling reactions, the benefits for react...

Artikel

Tuning Glycosyl Donor Reactivity via Nitroarene Protecting Groups: A Semiarmed Strategy for Selective Glycosylation

von Yuji Otsuka et al.

· 22.08.2025

A modular strategy reports to tune glycosyl donor reactivity using nitroarene protecting groups. These groups suppress donor reactivity and can be chemically converted into activating groups, enabling a switchable system. This approach broadens the ...

Artikel

Photocatalytic Cyclopropanation of Allenoates with 1,3,4‐Oxadiazolines

von Kacper Kisiel et al.

· 22.08.2025

Spirocyclic compounds are key scaffolds in many drugs and other bioactive molecules. While cyclopropanation of allenes is relatively straightforward, synthesis of spirocyclic compounds from these substrates is scarce. We report a photocatalytic, tra...

Artikel

Biindoles. A Synthetic Overview

von Jaime G. et al.

· 22.08.2025

Biindoles, a fascinating class of heterocycles present in several fields of science including the oldest known dye, is systematically but in a concise fashion reviewed, describing as key, point the synthetic strategies reported to date. The biindol...

Artikel

Adding “Energy” to Chalcogenophene Chemistry: Electrosynthesis of 2,3,5‐Trisubstituted Selenyl‐Chalcogenophenes and Their Interaction with DNA

von Vinícius D. et al.

· 21.08.2025

An electrosynthetic method is developed for synthesizing selenyl-chalcogenophenes via intramolecular cyclization of (Z)-chalcogenenynes under mild conditions and without external oxidants. Density functional theory calculations and cyclic voltammetr...

Artikel

Exhaustive Hydrodechlorination of Trichloroacetamides under Electrochemical Conditions at Ambient Temperature

von Manas Bandyopadhyay et al.

· 21.08.2025

Hydrogenation of trichloroacetamides to afford structurally diverse acetamide derivatives is achieved under environmentally benign, mild electrochemical conditions through an iodide-mediated crucial halogen-bonding interaction. The reaction mechanis...

Artikel

Photoinduced Copper Catalyzed C(sp2)P Bond Formation by Coupling of Diphenylphosphine with Aryl Iodides

von Cunyi Lu et al.

· 20.08.2025

P Bond Formation by Coupling of Diphenylphosphine with Aryl Iodides"/> A photoinduced Ullmann-type CP bond-forming reaction is accomplished at room temperature with no additional ligand. This method features broad substrate scope, scalability, and ...

Artikel

Two Metals, One Goal: Unlocking Reactivity with Heterobimetallic Systems for Organic Transformations

von Madhuri P. et al.

· 19.08.2025

The review involves heterobimetallic catalytic systems that provides access to various organic transformations which are obscure with conventional monometallic systems. It throws light on diverse organic reactions such as alkylation, alkenylation, a...

Artikel

Sustainable Synthesis of Isoxazoles and Isoxazolines Directly from Aldehydes via One‐Pot Metal‐Free Approach Using a Reusable Ionic Liquid [C8DABCO][OH] at Room Temperature

von Priyanuj K. et al.

· 19.08.2025

This study presents a one-pot and a multistep approach for the regioselective formation of 3,5-disubstituted isoxazoles, isoxazolines, and bis-isoxazoles at room temperature. The metal-free method enhances product yield, allowing lower catalyst load...

Artikel

Multicomponent Synthesis of Fluorine‐Containing Bioactive Compounds and Drugs

von Ivette Morales‐Salazar et al.

· 19.08.2025

Multicomponent reactions are robust synthetic tools to assamble complex polyheterocycles and other interesting molecular architectures with potential application in medicinal chemistry, including their fluorine-containing analogues. Fluorine atoms p...

Artikel

Synthesis of Diverse β,β‐Diaryl β‐Siloxy Diamines and Application as Organocatalysts

von Keidai Takahara et al.

· 18.08.2025

β,β-Diaryl-β-siloxy diamines are developed as diverse diamine organocatalysts. The synthetic methodology enables structural diversification through Grignard reactions, as well as subsequent silylation and amination. These diamines catalyzed enantios...

Artikel

Synthesis and Properties of 10‐Aryl‐11H‐indeno[2,1‐a]azulenes and Azuleno[2,1‐a]indenones

von Taku Shoji et al.

· 16.08.2025

A cycloaddition strategy for the synthesis of 10-aryl-11H-indeno[2,1-a]azulenes, as well as their derivatives, is presented. The work highlights improve reactivity using enamines from 1-indanone and pyrrolidine, followed by electrophilic chlorinatio...

Artikel

Multigram Copper‐Catalyzed Borylation of Functionalized Terminal Alkynes with B2Pin2

von Ihor Kleban et al.

· 16.08.2025

Application of cheap and accessible reactants for copper-mediated borylation of functionalized terminal alkynes is described. Based on the thorough assessment of different ligands/additives for various types of substrates, a simple decision tree for...

Artikel

Copper Coils as Efficient and Inexpensive Reactors for the Synthesis of Tetrazoles in Flow Chemistry

von Maite Molins et al.

· 14.08.2025

Copper-coil reactors are used for the synthesis of tetrazoles starting from benzonitriles in continuous flow. The reaction is carried out at high temperatures and residence times, in the presence of sodium azide, making the flow chemistry approach s...

Artikel

Substrate Divergent 4π/6π Electrocyclization of CF3‐Quinolone Heterodendralenes

von Chavakula Nagababu et al.

· 14.08.2025

A substrate-dependent 4π/6π electrocyclization of in situ generated CF₃-heterodendralenes from 4-methyl-3-trifluoroacetyl quinolones is described. Phenyl substitution favors 4π-electrocyclization to give CF₃-substituted cyclobuta[c]quinolones bearin...

Artikel

Cellulose‐Based Nanosponges Loaded with Palladium as Efficient Heterogeneous Catalysts for the Synthesis of Challenging Derivatives with Pharmaceutical Relevance

von Giulia Cazzaniga et al.

· 14.08.2025

This work presents a cellulose-based heterogeneous palladium catalyst (CNS-Pd) for the efficient and selective Suzuki–Miyaura synthesis of pharmaceutically relevant heterocyclic derivatives, including scaffolds derived from unstable boronic molecule...

Artikel

Efficient Hydrosilylation Reaction of Olefins Catalyzed by a Dinuclear Ruthenium Complex

von Fei Xie et al.

· 14.08.2025

Under mild reaction conditions, the dinuclear ruthenium catalyst is used to achieve an anti-Markovnikov hydrosilylation reaction of olefins. Notably, the reaction is extremely selective and no alkenylsilanes, olefin reduction products, or isomerizat...

Artikel

Molecular Iodine‐Mediated Functionalization of α‐Carbonyl Sulfoxonium Ylides with Thiocyanates, Xanthates, and Dithiocarbamates

von Kauê C. et al.

· 14.08.2025

A method for synthesizing α-xanthates, α-thiocyanates, and α-dithiocarbamates has been developed. By employing molecular iodine and the potassium salts of xanthates, thiocyanate, and dithiocarbamates, a wide range of products is obtained, with yield...

Artikel

Anion Recognition‐Induced Selective Separation of Phosphates from Complex Aqueous Matrices by Self‐Assembled Molecular Capsule

von Sandeep Kumar et al.

· 13.08.2025

A triethanolamine-based anion receptor functionalized with H-bond donating urea groups has been designed and synthesized for selective separation of hydrophilic phosphates from aqueous media of high anionic and cationic complexity. Competitive extra...

Artikel

Synthesis of Morpholine‐2,5‐Diones by Tandem of Azido‐Ugi and Ugi Reactions

von Alexander V. et al.

· 13.08.2025

The tandem of the azido-Ugi and four- or three-component Ugi reactions (Ugi-4CR, Ugi-3CR) becomes a new and unusual approach for the construction of a morpholine-2,5-dione ring functionalized with a tetrazole moiety. Preisolation of Ugi bisamides is...

Artikel

C4‐Regioselective Dearomatization of Quinolinium Salts via Morita–Baylis–Hillman Reaction

von Robert S. et al.

· 13.08.2025

Traceless switch of regioselectivity: without employing any directing groups, the change of selectivity in the Morita–Baylis–Hillman reaction with N-alkylquinolinium electrophiles is attained. Simply by modifying the counterion in the azaarenium sal...

Artikel

Transition‐Metal‐Catalyzed CH Activation Assisted by N,O‐Bidentate Directing Groups

von Raj N. et al.

· 13.08.2025

H Activation Assisted by N,O-Bidentate Directing Groups"/> Transition-metal-catalyzed directing group-assisted CH functionalization, offers atom-economical routes to synthesize and functionalize complex molecules. This review covers recent advancem...

Artikel

Role of Lewis Acids toward the Synthesis of Tetrahydrofuran Motifs: An Update

von Kiruthika Nachimuthu et al.

· 13.08.2025

The present review represents the fantasy of Lewis acid towards the synthesis of THF core. Lewis acid catalyzed/promoted annulation reactions are envisioned to be an effective strategy to architect THFs containing bioactive natural products and pha...

Artikel

Synthesis of N‐Arylated Lactam‐Type Iminosugars by Cascade Radical Cleavage of α‐Amino Carbonyl Compound and Intramolecular Amidation

von Yixuan Liu et al.

· 13.08.2025

A simple and efficient one-pot protocol has been developed for the synthesis of diverse N-arylated lactam-type iminosugars or 4-aminobutanamide derivatives through cascade radical cleavage of α-amino carbonyl compounds and intra-/intermolecular amid...

Artikel

A Bench‐Stable Monofluoroallylsulfonium Salt for Highly Regioselective Monofluoroallylation

von Ming‐Xing Qu et al.

· 13.08.2025

A novel monofluoroallylsulfonium salt (MFAS) is synthesized from the inexpensive industrial chemical 3,3,3-trifluoropropene in three steps with high efficiency. This reagent reacts readily with a series of alkylzinc reagents under copper catalysis t...

Artikel

Catalytic Advances and Emerging Strategies for Isoquinolin‐1(2H)‐One Synthesis: Reaction Scope and Mechanistic Perspectives

von Lucky Panwar et al.

· 13.08.2025

Isoquinolin-1(2H)-one is a core structure in many bioactive molecules, natural products, and advanced materials. Its efficient and sustainable synthesis has garnered significant attention in organic synthesis. This review highlights recent advanceme...

Artikel

A C3‐Symmetric Diphenylethylendiamine‐Based Catalyst in the Asymmetric Michael Addition of α,β‐Unsaturated Ketones with 4‐Hydroxycoumarin and 4‐Hydroxyquinolin‐2‐One

von Shilashi Badasa et al.

· 13.08.2025

Two C₃-symmetric organocatalysts with multiple amino groups are prepared and employed in the asymmetric addition of 4-hydroxycoumarin and quinoline-2-one to unsaturated ketones. The all-amino version of the catalyst induces the better stereoselectiv...

Artikel

Nickel Chloride Hexahydrate‐Catalyzed Regioselective Synthesis of Quinolines and Bis‐Quinolines Under Aerial Oxidation

von Apurva Singh et al.

· 11.08.2025

Synthesis of quinoline and bis-quinoline derivatives is reported using nickel chloride hexahydrate catalyst via Michael addition followed by aldol condensation from α,β-unsaturated ketone and o-aminobenzyl alcohol. The protocol enables access to pro...

Artikel

Mild Photocatalytic Hydrodecarboxylation of Fatty Acid Derivatives using Xanthene Dyes for Biomass Valorization

von Jhudson G. et al.

· 10.08.2025

An elegant xanthene-based method for metal- and hydrogen-free photocatalytic deoxygenation of lipidic biomass is reported, featuring DIPEA as a dual-function sacrificial reductant and hydrogen donor, enabling efficient one-pot C_n–1 hydrocarbon synth...

Artikel

PhI(OAc)2‐Mediated One‐Pot Synthesis of Pyridoquinazolinones from 2‐Aminobenzaldehydes and 2‐Chloropyridines

von Sayeed Mukhtar et al.

· 09.08.2025

A metal-free, mild, facile, and cost-effective one-pot hypervalent-iodine-mediated transformation was developed for the synthesis of pyridoquinazolinones from 2-chloropyridines at room temperature. This reported protocol can produce biologically act...

Artikel

Synthesis and Chiroptical Property of Chiral Heteroatom‐Embedded Zigzag‐Type Hydrocarbon Belts

von Zi‐Yue Jin et al.

· 09.08.2025

Fjord-Stitching Strategy Enables Chiral Heteroatom-Doped Zigzag Hydrocarbon Belts! Herein, the synthesis of chiral heteroatom-embedded hydrocarbon belts via fjord-stitching CN coupling reactions of easily accessible resorcin[4]arene and resorcin[6]...

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Synthesis of 12b‐Methyl‐Isoindoloisoquinolin‐8‐ones via Iridium‐Catalyzed Intramolecular Hydroarylation of Phenacyl Enamides

von Ashok R. et al.

· 09.08.2025

Our iridium-catalyzed hydroarylation methodology affords high product yields and does not require pre-functionalized substrates – a distinct advantage over conventional Heck-type cyclization protocols. Substrate scope and mechanistic investigations ...

Artikel

A Fullerene‐Based Selenosugar Ball

von Reinier Lemos et al.

· 09.08.2025

A fullerene hexakis-adduct decorated with 12 peripheral seleno-d-talitol moieties is synthesized efficiently with a T_h-symmetry from a hexakis-adduct of [60]fullerene prepared by a cycloaddition reaction and subsequent copper-catalyzed azide-alkyne ...

Artikel

The Reactivity of α‐Fluorinated Mono‐ and Diketones Uncovers their Potential as Electrophilic Warheads for Reversible Covalent Drugs

von Yossi Zafrani et al.

· 09.08.2025

The potential of fluorinated mono- and diketones as electrophilic warheads for reversible covalent drugs is described by studying their equilibria reactions with the protected nucleophilic amino acids serine, cysteine and lysine. Fluorinated diketo...

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Novel Ambergris Odorants Devoid of Ketal Functions: Sustainable Synthesis of 4‐(α‐Cedren‐8‐yl)Butan‐2‐Ones and Potent Methoxy Derivatives by Claisen Chemistry**

von Elisa Kuhnt et al.

· 08.08.2025

The mystery behind the new odorant. Ambronova from sustainable α-cedrane is not only the unusual polar methoxy group in the ketal moiety but also two novel methoxy ketones accessible in pure form by Claisen chemistry from β-cedren-9α-ol and methoxy ...

Artikel

Cobalt(I)‐Catalyzed E‐Selective Hydroalkynylation of Terminal Alkynes or Internal Alkynes with Silyl‐Substituted Terminal Alkynes

von Sebastian M. et al.

· 08.08.2025

The cross-hydroalkynylation of silyl-substituted terminal alkynes, acting as CH-donor alkynes, with aryl- or alkyl-substituted terminal alkynes, acting as acceptor alkynes, is described. Cross-hydroalkynylation with internal alkynes acting as accept...

Artikel

Denitrogenative Triazole Ring Cleavage in Synthesis of 2‐Functionalized (Cyclo)alkyl‐4.5‐Unsubstituted Oxazoles

von Viacheslav Lysenko et al.

· 07.08.2025

A series of 2-(cyclo)alkyl-substituted oxazoles is synthesized via a denitrogenative triazole ring-cleavage strategy. The solvent-free conditions allow the introduction of primary and secondary amines, as well as carboxylic and alkoxycarboxylic grou...

Artikel

Recent Advances in Catalyst‐Mediated [6 + 4] Cycloaddition Reactions: A Concise Review

von Gobind Kumar et al.

· 07.08.2025

Higher-order cycloaddition reactions, especially [6+4] cycloaddition reactions, have been widely applied in the construction of 10-membered rings and natural compounds. However, these reactions encounter several challenges, including achieving regio...

Artikel

A Concave Mirror Photoreactor Design for Visible‐Light Photocatalysis

von Marko Slijepcevic et al.

· 07.08.2025

A novel concave mirror-based photoreactor boosts reaction rates across diverse visible-light transformations. This modular, cost-effective design enhances illumination of the reaction mixture, accelerates photocatalytic transformations and supports ...

Artikel

Synthesis of Thioxothiazolidinone and Iminothiazolidinone Derivatives via Dicyano Epoxide‐Based Multicomponent Reactions in Green Media

von Hossein Yazdani et al.

· 07.08.2025

Multi-component reaction of dicyanoepoxide toward the efficient synthesis of thiazolidine-2-thiones, 2-imino-thiazolidin-4-ones and amido dithiocarbamate, in green media has been described. The use of green solvents, metal and catalyst-free, mild re...

Artikel

Syntheses of Annoglabasin A and Annomosin A, ent‐Kaurane Diterpenoids from Annonaceae, Using Stevia Sweetener as a Cost‐Effective Synthetic Source

von Yuuki Moriwaki et al.

· 07.08.2025

This article describes a cost-effective and scalable synthetic method for the preparation of ent-kaurane diterpenoids from commercially available stevia sweeteners. By enabling the efficient synthesis of ent-kaurenol, this approach facilitates acces...

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Sonogashira‐like Reaction of the Biellmann BODIPY and Fluorescence Staining of the Tomato Crop Bacterial Pathogen Clavibacter michiganensis with the Resulting Products

von María del et al.

· 07.08.2025

A meso-methylsulfanyl-BODIPY derivative (Biellmann BODIPY) underwent Sonogashira-like cross-coupling with terminal alkynes under mild conditions to yield a family of novel fluorescent meso-arylethynyl BODIPYs. These derivatives are characterized by ...

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Transition‐Metal‐Free Alkynylthiolation of Tertiary α‐Carbonyl Bromides

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Rhodium‐Catalyzed Directed C–H Heteroarylation of 2‐Pyridones Using Cyclic Iodonium Ylides

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Escape from Flatland: Pericyclic Reactions and Rearrangements of Diazofluorene with Biarylcyclooctynes for the Generation of Helicene‐Like Phenanthro‐Pyrazoles