A convenient method for acylation of [1.1.1]propellane to give bicyclo[1.1.1]pentane (BCP) carboxamides and ketones has been developed. It provides a straightforward one-step access to monosubstituted BCP carboxamides, synthesis of which requires...
Artikel
Trifluoromethylsulfinylation Reaction of Activated Arenes and Indoles with Trifluoromethanesulfinyl Chloride
European Journal of Organic Chemistry, März 2024, DOI. Login für Volltextzugriff.
Von Wiley-VCH zur Verfügung gestellt
A facile method for the trifluoromethylsulfinylation of activated arenes with trifluoromethanesulfinyl chloride in the presence of Lewis acid was developed. The protocol could be expanded to the perfluoroalkylsulfinylation of activated arenes, as well as the trifluoromethylsulfinylation of indoles without additive.
Abstract
The trifluoromethylsulfinylation reaction of activated arenes with trifluoromethanesulfinyl chloride (CF3SOCl) in the presence of Lewis acid was achieved under mild and solvent-free conditions. A series of aryl trifluoromethyl sulfoxides were obtained in moderate to high yields. The protocol could be extended to the perfluoroalkylsulfinylation of activated arenes, as well as the trifluoromethylsulfinylation of indoles without additive.
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