ArtikelEffective Enzymatic Synthesis of Benzotropolone and Formation Mechanism of Its Bicyclo[3.2.1]octane‐type Intermediatevon Yangping Ding et al. · 21.09.2023 Pyrogallol (PG) plays a crucial role in synthesizing benzotropolone (BTP). This is because it can not only couple with catechol (CC) to form BTP, two PG molecules can also produce purpurogallin (PPG) that has the same skeleton as BTP. Furthermore, P...
ArtikelSynthesis of Secondary Trifluoromethylated Alkyl Bromides with Further Conversion to Boronic Esters and Alcoholsvon Weipiao Li et al. · 21.09.2023 A general deaminative cross-coupling reaction of Katritzky salts with 2-bromo-3,3,3-trifluoropropene (BTP) as a route to α-trifluoromethylated alkyl bromides has been developed that is driven by an electron-donor-acceptor (EDA) complex. Abstract S...
ArtikelBrønsted Acid–Catalyzed Tandem Reaction of 1,4‐Enediones with 2‐Naphthols: Synthesis of 2‐Furylmethylnaphthalenesvon Cong‐Hui Gao et al. · 21.09.2023 A Brønsted acid-catalyzed tandem reaction of 1,4-enediones with aromatic nucleophiles was developed, affording a series of 2-furylmethylarenes in high yields (up to 98%). The attractive features of this reaction include mild reaction conditions, ove...
ArtikelAlkylation of an N2‐Derived PN3P Mo(V) Nitride Complexvon Delong Han et al. · 21.09.2023 Nitride ligand alkylation of a post-modified PN3P−Mo(V) nitride complex was achieved using MeOTf and EtOTf. In contrast to known Mo(VI) complexes, the resulting alkylated Mo(V) complexes showed distinct reactivity, where NaH served as a reducing age...
ArtikelSynthesis of 4H‐Indazol‐4‐ones and Fused Pyrazoles via Copper‐Catalyzed Annulation of Hydrazones with Cyclic Enonesvon Kalinga H. et al. · 21.09.2023 The copper-catalyzed annulation reaction between hydrazones and cyclic enones (5-, 6-, and 7- membered) affords diversely functionalized fused pyrazoles. These molecular scaffolds have been further functionalized successfully. Abstract Herein, we ...
ArtikelChemoselective Catalytic Dehydrogenation of Benzylic Amines Driven by the TEtraQuinoline/FeCl2 Complexvon Mizuki Nishiwaki et al. · 21.09.2023 A super-rigid TEtraQuiniline (TEQ) contributes to realize a robust oxidative catalytic system with FeCl2 and tert-butyl hydroperoxide (TBHP), allowing for chemoselective dehydrogenation of benzylic amines to the corresponding imines. TON reaches 225...
ArtikelCobalt‐Catalyzed Multi‐Substituted Alkene Synthesis from 1,3‐Dithiolanes and Grignard Reagentsvon Timothy A. et al. · 21.09.2023 An efficient cobalt-catalyzed olefination of 1,3-dithiolanes with Grignard reagents is reported. Good to excellent yields of a variety of valuable multi-substituted alkene motifs were obtained using an inexpensive CoBr2 catalyst system. The operatio...
ArtikelTert‐Butylnitrite Mediated Regioselective C(sp2)−3 Nitration of Substituted 4‐Quinolones and Its Late‐stage Manipulationsvon Prasanjit Ghosh et al. · 21.09.2023 A unified approach for the regioselective C(sp2)3-H nitration has been developed to expedite the access of nitro derivatives of 4-quinolones in presence of t-BuONO (nitrating agent)/TEMPO. The protocol tolerated diverse functional groups and substit...
ArtikelExpanding the Diversity of Azepino [3,2,1‐hi] Indoles via Transition Metal‐based Strategies such as Cross‐coupling Reaction and Ring Closing Metathesisvon Sambasivarao Kotha et al. · 21.09.2023 Synthetic strategies to azepino hi-indoles via palladium catalyzed cross-coupling reaction and ring closing olefin metathesis (RCM) as key steps are reported. Several useful strategies to synthesize azepino hi-indoles using commercially available in...
ArtikelDABCO Mediated Sulfur Activation‐Intramolecular De‐Nitration Strategy for the Synthesis of Novel Dihydrothiochromeno[4,3‐c]pyrazolesvon Avijit K. et al. · 21.09.2023 An efficient metal-free approach has been unfolded for the synthesis of novel dihydrothiochromeno[4,3-c]pyrazoles using elemental sulfur as a powerful sulfurating reagent. Abstract A facile and highly efficient metal-free approach has been unfolde...
ArtikelPhotoinduced Copper(II) Catalyzed Decarboxylative Homocoupling of Arylpropiolic Acids: A Facile Access to the Symmetrical 1,3‐Diynesvon Vishali Pathania et al. · 21.09.2023 We have demonstrated a photoinduced copper mediated decarboxylative homocoupling of arylpropiolic acids to synthesize, 3-diynes. A variety of arylpropiolic acids containing electron-rich as well as electron-deficient groups undergo conversion to aff...
ArtikelKOtBu‐Mediated Regioselective Hydroxymethylation of Thiazoles and Benzothiazoles: Synthesis of Biologically Active Heteroaromatic Compoundsvon Shilpi Karmakar et al. · 21.09.2023 A transition metal-free direct C-2 hydroxymethylation of thiazoles with ketones in the presence of KO t Bu to construct thiazole-2-diarylcarbinols is delineated. Complementary to cross-coupling technologies with azole halides and organometallic r...
ArtikelA Rapid Bioinspired N‐Acyliminium Ion Strategy for the ABC Core of the Stemona Alkaloidsvon Subhash P. et al. · 21.09.2023 Synthesis of the tricyclic core of the (−)-stemoamide and 8,9-bis-epi-stemoamide was achieved from commercially available L-malic acid. The synthetic approach features a bioinspired trifluoroacetic acid-mediated key cationic cyclization, regioselect...
ArtikelEfficient Amide Formation from Non‐Activated Cyclopropyl Ester via Acyl Fluoride Generation Using Hypervalent Iodine(III) Reagent and Selectfluorvon Eun‐Sol Choi et al. · 21.09.2023 A novel and unique activation method for esters possessing a non-activated cyclopropyl moiety as a potential activating group is developed for acyl fluoride generation using a hypervalent iodine(III) reagent and Selectfluor. The resulting acyl fluor...
ArtikelNHC‐Catalyzed Radical Tandem Cyclization/Coupling Reaction for the Synthesis of 2‐Pyrrolidinone Derivativesvon Nengneng Zhou et al. · 21.09.2023 A novel strategy for synthesizing structurally diverse 2-pyrrolidinons by a NHC-catalyzed tandem radical cyclization process has been developed. This reaction proceeds through a radical coupling approach, which not only shows broad substrate scope w...
ArtikelSynthesis and Functionalization of Spirocyclic Compounds Derived from Tetrahydrobenzoxazol‐2‐onesvon Tania I. et al. · 21.09.2023 Due to their great versatility and diversity, bis-chalcones represent a good scaffold for obtaining new spirocyclic compounds derived from tetrahydrobenzoxazol-2-ones which can be functionalized by reactions with nucleophiles such as dimethyl malona...
ArtikelPhIO‐Mediated Cascade Reactions of Activated Acetylamides and Cyclic Amidines: Access to Polysubstituted Imidazolidin‐2‐onesvon Xuebei Ye et al. · 21.09.2023 One-pot synthesis of polysubstituted imidazolidin-2-ones has been achieved via oxidative reactions of activated acetyl amides and cyclic amidines in the presence of iodosobenzene (PhIO), which involves sequential intermolecular addition, Hofmann-typ...
ArtikelThree‐Component Aza‐Diels‐Alder Reaction for the Syntheses of Tetrahydroisoquinoline Derivativesvon Aurapat Ngamnithiporn et al. · 21.09.2023 A series of tetrahydroisoquinoline derivatives were prepared via a three-component aza-Diels-Alder reaction. Keys to the success of this reaction are a) the utilization of sultines as masked o-quinodimethanes, b) the facile, in situ generation of im...
ArtikelN‐Heterocyclic Carbene‐Catalyzed [3+3] Annulation of Alkynyl Acyl Azolium with β‐Keto Ester for the Synthesis of Tri‐Substituted α‐Pyranonesvon Chengming Jiang et al. · 21.09.2023 The N-heterocyclic carbene (NHC)-catalyzed [3+3] annulation of alkynyl acyl azoliums with β-keto esters has been achieved. This approach extends the reactivity of alkynyl acyl azoliums and provides an efficient scenario for the synthesis of tri-subs...
ArtikelFront Cover: Chemoselective Catalytic Dehydrogenation of Benzylic Amines Driven by the TEtraQuinoline/FeCl2 Complex (Asian J. Org. Chem. 9/2023)von Mizuki Nishiwaki et al. · 21.09.2023 The Front Cover image illustrates the proficiency of the TEtraQuinoline (TEQ)/Fe(II) complex in oxidative catalysis. The macrocyclic architecture was faintly drawn as a black scaffold, and the nitrogen atoms and the Fe(II) cation are highlighted wit...
ArtikelTransition‐Metal‐Free Synthesis of N‐Heterocyclic Compounds via Multi‐Component Reactionsvon Dhruba Jyoti et al. · 21.09.2023 Transition-metal-free multi-component reactions have been widely explored to synthesize numerous N-heterocycles. A concise report and general outlook towards the transition-metal-free synthesis of various N-heterocycles are presented in this review....
ArtikelSynthesis of Polysubstituted Furans: An Update Since 2019von Suhasini Mohapatra et al. · 21.09.2023 Due to the wide range of biological activities of polysubstituted furans, several synthetic techniques have been devised. This review article describes the most recent developments in the synthesis of polysubstituted furans using transition-metal ca...
ArtikelElectrochemical Cyclization of α,β‐Alkynic Hydrazones and Primary Amines for the Synthesis of 3‐Alkynyltriazoles
ArtikelPIDA Mediated Synthesis of Benzopyranoisoxazoles via an Intramolecular Nitrile Oxide Cycloaddition (INOC): Application to the Synthesis 4H‐chromeno[4,3‐c]isoxazol‐4‐ones.von Rohit Kumar et al. · 04.10.2023 An approach for the synthesis of highly substituted tricyclic benzopyranoisoxazoles from the corresponding aldoximes has been reported. The reaction proceeds via an intramolecular nitrile oxide cycloaddition (INOC) process using a catalytic amount o...
ArtikelPd‐Catalyzed Switchable Access to Imines and Amines from Secondary Alcoholsvon Daniel Raydan et al. · 04.10.2023 This work describes a switchable access to imines and amines from secondary alcohols using a Pd(OAc)2 catalyst. The synthesis of imines occurs through acceptorless alcohol dehydrogenation (ADC) under optimized conditions. Notably, when the catalytic...
ArtikelSulfur‐doped carbon nitride efficiently catalyzes the photooxidation/ acetalization of alcohols to acetals/ketals in tandem
Artikel18F‐Fluorination of 2‐methyl‐6‐nitrobenzenesulfonate ester and its application to the synthesis of a 18F‐labeled amino acid.
ArtikelAcid‐Promoted Electron Transfer with Inverse Kinetic Isotope Effect for Disproportionation of Nitroxyl Radicals in CH3CN
ArtikelFirst subphthalocyanine analogue with fused 6H‐1,4‐diazepine ring and its conversion to aminobenzamide derivative.
ArtikelHypervalent Iodine‐Mediated Alkyne Functionalization: Facile Access to Trifluoromethyl‐ and Pentafluoroethyl‐Substituted Thiazolesvon Yoonna Kwak et al. · 28.09.2023 The use of hypervalent iodine with Lewis acid provided alkyne trifluoromethylation and pentafluoroethylation to access trifluoro-and pentafluoro-substituted thiazoles. Abstract The use of hypervalent iodine with Lewis acid provided alkyne trifluor...
ArtikelCu‐Catalyzed Enantioselective Reductive Coupling of 1,3‐Dienes and Carboxylic Acid Anhydridesvon Wenxin Lu et al. · 28.09.2023 The Cu−H catalyzed enantioselective reductive coupling of 1,3-dienes and anhydrides via enantioenriched allyl-Cu species is reported herein, affording homoallylic alcohols bearing Z-alkenes in good yield and enantioselectivity. Functionalization of ...
ArtikelProgression on Oxidative Decyanation Approaches from Secondary Nitriles to Ketones and α‐Aminonitriles to Amides
ArtikelTransition‐metal‐free Cyclization of Mucohalic Acids with Sulfonyl Hydrazides: An Approach to Pyridazin‐3(2H)‐onesvon Qi Chen et al. · 27.09.2023 A metal-free reaction promoted by p-toluenesulfonic acid for the construction of pyridazin-3(2H)-ones starting from mucohalic acids and sulfonyl hydrazides has been developed. The reaction without any metal catalyst or additive is carried out in air...
ArtikelNovel Furan‐Pyrazole Molecular Hybrids as Prospective Anti‐Neuroinflammatory Agents: Design, Synthesis, and In‐Vitro Screening Thereofvon Sowjanya Mudimela et al. · 25.09.2023 A small library of (1H-pyrazole-1-carbothioamido) acetamido) furan-3-carboxamide molecular hybrids were designed and molecular docking was performed against HMGB1 and HMGB1 Box A proteins. A total of ten derivatives were selected based on binding sc...
ArtikelOrganocatalytic Enantioselective One‐pot Synthesis of Dihydrocoumarins via C−H Oxidation and Cyclization Cascadevon Kyeong Seop et al. · 25.09.2023 An efficient one-pot synthesis of chiral 3,4-dihydrocoumarin derivatives via C−H oxidation, Michael addition and cyclization cascade of 2-benzyl phenol derivative with 5-(4H)oxazolones has been successfully developed. This transformation is catalyze...
ArtikelRegioselective Carbozincation and Further Functionalization of Allenamides Catalyzed by an N‐Heterocyclic Carbene (NHC)‐Copper Complexvon Masanori Takimoto et al. · 22.09.2023 Synthesis of β,β-disubstituted enamides: Formal β,γ-difunctionalizationof allenamides has been achieved by a combination of γ,β-selective carbozincation catalyzed by an NHC-copper complex and the subsequent functionalization process, such as a Pd-ca...
ArtikelOxidative Cleavage of C−C Bonds in Non‐aromatic Oxygenates with Molecular Oxygen for Synthesis of Carboxylic Acidsvon Yoshinao Nakagawa et al. · 22.09.2023 Selective cleavage of bonds between functionalized carbon atoms with appropriate catalysts and molecular oxygen cleanly gives useful carboxylic acids or diacids. In particular, oxidation systems in water solvent without base additive are useful in v...
ArtikelFeCl3 ⋅ 6H2O Mediated Sequential Oxidative Cleavage and Spiro Coupling of Peroxyoxindole with Cyclic‐1,3‐diketone/1‐Naphthol for the Synthesis of Spirooxindolo‐Xanthene Derivativesvon Gokul S. et al. · 22.09.2023 A new approach for the synthesis of various hexahydro-1H-xanthene-1,8-dione or dibenzo xanthene containing spirooxindole derivatives is reported by using peroxyoxindole and 1,3-diketone or naphthalene-1-ol in the presence of FeCl3 ⋅ 6H2O complex. Th...
ArtikelPhotoredox‐Catalyzed Three‐Component Difluoroalkylation of Quinoxalin‐2(1H)‐ones with Unactivated Vinylarenes and [Ph3PCF2H]+Br−von Yuandong Xu et al. · 20.09.2023 A photocatalytic oxidative protocol for the synthesis of 3-difluoroalkyl quinoxalin-2(1H)-ones derivatives was developed via the difluoroalkylation of quinoxalin-2(1H)-ones with unactivated vinylarenes and [Ph3PCF2H]+Br−. Abstract An efficient syn...
ArtikelPhotothermal Aza‐Michael Addition of Divergent Amines to Vinyl Sulfones: A Method Towards Transition Metal‐ and Base‐Free Mediumvon Tamilselvan Duraisamy et al. · 15.09.2023 This photothermal convention was developed for different amines and sulfone derivatives, and excellent yields of the desired sulfone-substituted heterocycles were obtained. The process is mild and operationally simple to perform in batch and continu...
ArtikelPd‐catalyzed Three‐component Cross‐coupling of Arylhydrazides with Arylboronic Acids and TFBen: Facile Access to Diaryl Ketones via Denitrogenative Carbonylationvon Wei Zhang et al. · 15.09.2023 A Pd-catalyzed oxidative carbonylation of arylhydrazines and phenylboronic acids which provides access to diaryl ketones with N2 and H2O as the only byproducts is reported. Abstract Carbonylation with CO surrogates is one of the most common method...
ArtikelVisible Light‐Induced Decarboxylative Peroxidation of Carboxylic Acids: Metal‐Free Synthesis of Benzyl Peroxidesvon Chenhao Lou et al. · 15.09.2023 A visible light-induced decarboxylative peroxidation of carboxylic acids has been disclosed. With this protocol, a variety of readily available carboxylic acids were converted to the stabilized organic peroxides in moderate to good yields. Abstrac...
ArtikelAcid‐Catalyzed Alkylation of NH‐1,2,3‐Triazoles with Alcoholsvon Xuyang Chen et al. · 14.09.2023 A general acid-catalyzed dehydrative coupling reaction of NH-1,2,3-triazoles with various alcohols was reported. This reaction afforded N-alkylated 1,2,3-triazoles with high overall yield. Allylic alcohols and triphenyl methanol together with 1,1-di...
ArtikelOrganocatalytic Diastereoselective Dearomative [4+2] Cyclodimerization of In‐situ Generated ortho‐Quinone Methidesvon Sushree Ranjan et al. · 14.09.2023 A straightforward synthesis of spiro-naphthalenone from in-situ generated naphthol-derived ortho-quinone methides is presented through TFA-catalyzed dearomative [4+2] cyclodimerization. Moreover, in the process, a diastereomeric interconversion of t...
ArtikelDesign, Synthesis, and Molecular Docking Analysis of Fluorinated MLN4924 Derivatives as Antiviral Agentsvon Kisu Sung et al. · 12.09.2023 MLN4924 derivatives with modified sugar moieties were synthesized and their inhibitory effectiveness against HCMV evaluated using a luciferase assay on human fibroblast cells. Docking studies elucidated the crucial role of the conformation of the su...
ArtikelCu‐Catalyzed Cross‐Coupling Reactions of Enamines and Terminal Alkynes: Access of Propargylamines as Neurodegenerative Disorder Agentsvon Lakavathu Mohan et al. · 12.09.2023 Reactions between enamine analogues and terminal alkynes were explored. Copper(I) complex of 1,10-phenanthroline catalyzed these reactions to generate a diastereoselective propargylamines via C−C bond formation. In the presence of Zn2+, the chiral p...
ArtikelSynthetic Strategies for the Construction of Indolizines and Indolizine‐fused Compounds: Thienoindolizines and Indolizinoindolesvon Alisa A. et al. · 08.09.2023 The approaches to the synthesis, properties and application of various indolizine derivatives and its fused derivatives such as thienoindolizines and indolizinoindoles are summarized in this review. The study focuses on the recent articles on the to...
ArtikelCu‐Catalyzed Site‐ and Enantioselective Borylcyanation of 1,2‐Disubstituted Aryl Alkenesvon Xiaofeng Jie et al. · 04.09.2023 A new method for enantioselective borylcyanation of 1,2-disubstituted alkenes promoted by chiral phosphine-Cu complexes was developed. This protocol represents the first catalytic enantioselective approach for simultaneous introduction of a cyano an...
ArtikelElectrochemical Hydrogenation of Organic Compounds: A Sustainable Approachvon Krishnapriya Jayan et al. · 04.09.2023 Electro-organic hydrogenation: Conventional methods for hydrogenation of organic compounds generally use corrosive catalysts and reagents, along with extreme conditions like high temperatures and pressures. Electro-organic hydrogenation reactions ha...
ArtikelMetal‐free Reaction of Allenamides with In‐Situ Formed Trifluoromethylnitrones as a Route to Highly Functionalized Isoxazolidinesvon Usha Yadav et al. · 01.09.2023 An additive-free reaction of allenamides with in situ-generated trifluoromethylnitrones has been uncovered to access an interesting class of trifluoromethylated methyleneisoxazolidines. The reductive cleavage of the N−O bond of isoxazolidines provid...
ArtikelRecent Advancement on the Organocatalyzed Asymmetric Conjugate Addition using Maleimide as a Potential Substratevon Barnali Jana et al. · 01.09.2023 The use of unprotected and protected maleimides as electrophiles was employed to synthesize new succinimide-based organic molecules using several catalytic approaches. In this review, we present an overview of the past 10 years progress on the asymm...
ArtikelSynergistic Dual Photoredox and Chiral Hydrogen Bonding Catalysis: Recent Advancesvon Sermadurai Selvakumar · 31.08.2023 In this review, we systematically summarized the recent advances in the field of dual photoredox and chiral hydrogen bonding catalysis in organic transformations. The review also features the detailed mechanistic studies and substrate scope of the k...
ArtikelRuthenium‐Catalyzed Pyridyl‐Directed C−H Allylation of Arenes with 1‐Aryl‐2‐vinylpyrrolidinesvon Hang Yu et al. · 31.08.2023 The Ru-catalyzed reaction of 2-arylpyridines with 1-aryl-2-vinylpyrrolidines affords C−H allylation species of arenes with the retention of amino groups in the product molecules. Abstract The [Ru(p-cymene)Cl2]2-catalyzed reaction of 2-arylpyridine...
ArtikelIridium Nanoparticles on SPIONs as a Catalyst for N‐Heteroarene and Styrene Hydrogenation Reactions and their DFT Studiesvon Afnan M. et al. · 31.08.2023 This study presents the fabrication process of an iridium-based catalyst on a magnetic support and investigates its effectiveness as a catalyst for hydrogenation reactions under the influence of molecular hydrogen pressure. Abstract In this study,...
ArtikelDioxaborin Compounds with Terminal Carbazole Groups: Enhancing Electron Acceptor in Organic Photovoltaicsvon Hironori Kobayashi et al. · 31.08.2023 The transformation of an electron donor into an electron acceptor in organic photovoltaics (OPVs) was achieved. A triphenylamine-based dioxaborin compound functioned as an electron donor and a new carbazole-based compound functioned as an electron a...
ArtikelA Simple Method for the Formation of α‐Thioalkyl Radicals and the Promotion of Carbon‐Carbon Bond Formation by Photoirradiation of Electron Donor‐Acceptor Complexesvon Pijush Kanti et al. · 31.08.2023 An electron donor-acceptor complex is formed between thioanisole and benzylidenemalononitrile. This complex, when irradiated, generates α-thioalkyl radicals that are instrumental in carbon-carbon bond formation Abstract This study documents the fo...
ArtikelPd‐Catalyzed Decarboxylative Cross‐Coupling of N‐Aryl Anthranilic Acids to Access Carbazoles: Gram Scale Total Synthesis of Anti‐ Cancer Drug Ellipticinevon Lavanya Nadella et al. · 31.08.2023 An efficient and scalable Pd-catalyzed decarboxylative cross-coupling strategy for the synthesis of carbazoles has been developed by using N-aryl anthranilic acids. By employing a well-designed catalytic system, this protocol access diverse carbazol...
ArtikelCopper‐Catalyzed N,N‐Alkyl Formylation of Sulfonamidesvon Arti Ramani et al. · 31.08.2023 Here, we have developed a highly efficient method for the N,N-alkyl formylation of sulfonamides, employing the reaction between orthoformates and sulfonamides to facilitate the synthesis of sulfonyl formamides. Abstract Herein, we have developed a...
ArtikelRh(III)‐Catalyzed C−H Annulation and Spirolactonization of 2‐Aryl‐1H‐benzo[d]imidazoles with 4‐Hydroxy‐2‐alkynoates via C−H bond activationvon G. Siva et al. · 31.08.2023 A novel C−H annulation and lactonization strategy has been for the first time for the synthesis of a diverse range of spiro[benzo[4,5]imidazo[2,1-a]isoindole and fused dimethylbenzo[4,5]imidazo[2,1-a]furo[3,4-c]isoquinoline derivatives Abstract Rh...
ArtikelVisible Light Photoredox Aziridination of Chalconesvon Oj Shikhar et al. · 31.08.2023 The aziridination of chalcones with iminoiodinanes under photoredox conditions has been reported. The reaction proceeds through nitrene radical anion intermediates generated from iminoiodinanes. The scope of the reaction is considerably wide and tra...
ArtikelVisible light‐induced monofluoroalkylation of (hetero)arenes with diethyl 2‐bromo‐2‐fluoromalonatevon Yalong Li et al. · 31.08.2023 This study reported the development of a visible light-promoted monofluoroalkylation of (hetero)arenes with diethyl 2-bromo-2-fluoromalonate as the radical precursor. A wide variety of monofluoride-containing compounds were directly synthesized with...
ArtikelDual Photosensitizer Cycles Working Synergistically in a C(sp)‐C(sp3) Cross‐Coupling Reaction von Megan Amy et al. · 31.08.2023 The image shows a proposed mechanism for the formation of the C(sp)-C(sp3) cross-coupled product from bromoalkynes and N-(acyloxy)phthalimde. The mechanism involves both a photocatalytic cycle and a separate photoreductant pathway, employing a Hantz...
ArtikelA Tandem Reaction in the Synthesis of New 4,8‐Disubstituted‐pyrimido[5,4‐d]pyrimidine Derivativesvon Ashly Rocha et al. · 29.08.2023 4,8-Disubstituted-pyrimido[5,4-d]pyrimidines 5 were obtained from 3,4-dihydropyrimido[5,4-d]pyrimidines derivatives 2 by two synthetic approaches. The one-step approach, involving a tandem reaction, is a simple, expeditious and broad-scope method, w...
ArtikelNew Ag(I)−NHC/TBHP System for Oxidative Coupling of α‐Hydroxy Acetophenones with Amines: A Base‐Free and Efficient Synthesis of α‐Ketoamides in Watervon Mohammad Muqeed et al. · 29.08.2023 Herein, we developed a base-free and efficient one-pot α-ketoamide bond formation promoted by Ag(I)−NHC/TBHP system via tandem oxidative coupling between α-hydroxy acetophenones and amines in water. Abstract A base-free and efficient tandem one-po...
ArtikelTfOH‐Catalyzed Highly Regioselective Synthesis of Conjugated Enones by Coupling of Alkynes and Aldehydesvon Mokhamatam Sudheer et al. · 28.08.2023 An efficient and regioselective triflic acid-catalyzed enone synthesis from intermolecular coupling reaction of aldehydes and alkynes has been developed. The present reaction is very effective, simple and mild and has varied scope for different subs...
ArtikelMechanochemical Metal‐free N‐Sulfonyl Transfer Reaction: Expedient Synthesis of N‐Sulfonyl Amidinesvon Souvik Guha et al. · 25.08.2023 The mechanochemical synthesis of diverse sulfonyl amidines from iminoiodinanes is an efficient and environmentally friendly approach to access a wide range of valuable compounds. Abstract An operationally simple mechanochemical reaction between im...
ArtikelSynthesis of Isochromeno[3,4‐d]imidazoles via Rh(II)‐catalyzed [3+2] Annulation between 4‐Diazoisochroman‐3‐imines and Oximesvon Minghui Qi et al. · 23.08.2023 A seriES of isochromeno[3,4-d]imidazoles were constructed through the Rh(II)-catalyzed [3+2] annulation reaction of 4-diazoisochroman-3-imines with oximes. Abstract A series of isochromeno[3,4-d]imidazoles were synthesized in good yields via Rh(II...
ArtikelA Mechanistic Study about the Formation of Tetracyanobutadienes Revealed an Autocatalytic Behaviorvon Loïc Lemiègre et al. · 20.07.2023 In a recent paper in Chemistry – A European Journal, Nielsen and coworkers reported a deep study on the mechanism of the [2+2] cycloaddition-retroelectrocyclization (CA-RE) inducing the formation of 1,1,4,4-tetracyanobutadienes (TCBD), which is now ...
ArtikelUVA LED Light Promoted Cross‐Coupling of Tertiary α‐Silylamines with 1‐Iodoalkynesvon Yichao Zhao et al. · 20.06.2023 A synthetic method to prepare propargyl amines efficiently from tertiary α-silylamines and 1-iodoalkynes under UVA LED light is described. Achieved under mild reaction conditions at room temperature, the site- and chemoselective approach was shown t...
ArtikelCopper‐Mediated (2‐Methylthio)aniline Directed Annulation of sp2 C−H Bonds with Primary Anilinesvon Khoa M. et al. · 08.08.2021 Directed amination of sp2 C−H bonds is often limited to secondary, aliphatic amines. Herein, a method for coupling of ortho C−H bonds in (2-methylthio)aniline benzamides with primary anilines is developed. Copper(II) pivalate was crucial for success...
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