ArtikelNHC‐Catalyzed Cascade Reactions for the Construction of Fused Cycles via LUMO Activation of α,β‐Unsaturated Carbonylsvon Guihua Nie et al. · 20.02.2023 LUMO-activations of a diversity of carbonyl compounds have played significant roles in the multi-cycle establishment promoted by NHC organic catalysts. An overview is provided on the cascade cycloaddition reactions for fused cycle constructions via ...
ArtikelTotal Syntheses of h5‐HT2A Receptor Antagonist, FPTase Inhibitor, FGIN‐1‐27 and its Analog by Exploiting NHC‐Catalyzed Imine Umpolung as Key Stepvon Battu Harish et al. · 20.02.2023 The NHC-catalyzed imine umpolung has been applied and demonstrated in the total syntheses of potent biologically active 2,3-disubstituted indole derivatives. The total syntheses of the titled molecules have been accomplished in high overall yields. ...
ArtikelAssembly of Dihydropyridazines via [4+2] Cycloaddition of In Situ Generated Azoalkenesvon Cheng Yuan et al. · 20.02.2023 The synthesis of multi-substituted pyridazines via [4+2] cycloaddition of azoalkenes generated in situ is described. This protocol features broad substrate scope and allows rapid assembly of pyridazines. The synthesis route provides an alternative m...
ArtikelA new entrant in ketene family: Generation of 2‐(3‐Oxo‐allyl)‐isoindole‐1,3‐dione and their [4+2] Cycloadditions with 1,3‐Diazabuta‐1,3‐dienesvon Rayees Ahmad et al. · 20.02.2023 The manuscript describes the formation of 5-(methylisoindole-1,3-dione) pyrimidinones by [4+2] cycloaddition reactions of functionalized 1,3-diazabuta-1,3-dienes with 2-(3-Oxo-allyl)-isoindole-1,3-dione generated in situ from phthaloylalanine and to...
ArtikelEnantioselective C−H Borylation for the Synthesis of Axially Chiral N‐Aryl Phthalimidesvon Hongliang Zhao et al. · 20.02.2023 A combination of a chiral bidentate boryl ligand (CBL) and an iridium precursor was found effective to catalyze C−H borylation of N-aryl phthalimides in an enantioselective manner, affording a variety of N−C axially chiral products (31 examples) wit...
ArtikelPhoto‐Triggered Synthesis of Sulfonamides in a Sustainable Solvent via Electron Donor‐Acceptor Complexvon Arsala Kamal et al. · 20.02.2023 A visible-light-triggered strategy for synthesis of sulfonamides was developed via electron donor-acceptor (EDA) complex in the more environmentally friendly green solvent 2-methyltetrahydrofuran (MeTHF), with excellent functional group compatibilit...
ArtikelEffective N‐Heterocyclic Carbenes with Indole Moiety Applied in the Pd‐Catalyzed Synthesis of Sterically Hindered Biarylsvon Yu‐Ting Lai et al. · 20.02.2023 Indolyl-based benzimidazolium salts have been prepared and exhibit high catalytic performance in Pd-catalyzed tri-ortho-substituted biaryls synthesis. In the presence of 0.5 mol% of Pd(OAc)2/1 i catalyst, the Suzuki-Miyaura cross-coupling of aryl ch...
ArtikelArylethanolamines in Ritter reaction: Synthesis of 2,4‐Diarylimidazole Corevon Anastasia A. et al. · 20.02.2023 Arylethanolamines react with nitriles in Ritter reaction promoted by perchloric acid to give 2-methylamino-1-(acylamino)-1-arylethanes in 33–82% yields. The latter were used as precursors in the synthesis of imidazole core via thermal cyclization an...
ArtikelVisible‐Light‐Promoted Electron Donor‐Acceptor Complex Enabled Decarboxylative Alkylation of Quinoxalin‐2(1H)‐ones and N‐Hydroxyphthalimide Esters with Na2S as a Catalytic Donorvon Hai‐Yang Song et al. · 20.02.2023 Various 3-alkylated quinoxalin-2(1H)-ones were synthesized through electron donor-acceptor complex enabled alkylation of quinoxalin-2(1H)-ones with N-hydroxyphthalimide esters (alkyl source) and Na2S (catalytic electron donor) under external photoca...
ArtikelCopper‐Catalyzed Regio‐ and Diastereoselective Borylacylation of α,β‐Unsaturated Estersvon Soshi Nishino et al. · 20.02.2023 A copper-catalyzed borylacylation of α,β-unsaturated esters with B2pin2 and acyl fluorides has been developed to afford the β‘-boryl-β-ketoesters with high anti-diastereoselectivity (up to >99 : 1). Additionally, the borylcarbamoylation can also ...
ArtikelIodine‐Catalyzed α‐Hydroxylation of β‐Dicarbonyl Compoundsvon Zhongkang Yang et al. · 20.02.2023 An iodine-catalyzed aerobic α-hydroxylation reaction of β-dicarbonyl compounds is established under transition-metal-free conditions. This synthetic approach is applicable to a broad variety of readily accessible substrates and can be conveniently c...
ArtikelElectrochemical Oxidative Cross‐Coupling of Pyrazolones and Diselenides to Construct C‐Se Bondsvon Fangling Lu et al. · 20.02.2023 An efficient electrosynthesis of a series of 4-seleno-substituted pyrazolone analogues derivatives has been developed via electrochemical oxidative cross-coupling of pyrazolones and diselenides under metal-free and external oxidant free conditions. ...
ArtikelRh(III)‐Catalyzed [4+2]‐Annulation of Indoles: Access to Functionalized Pyrimidoindolones Containing α‐Amino Acid Frameworkvon Daria V. et al. · 20.02.2023 Metal-catalyzed C−H bond activation strategy has been utilized to access a new family of CF3-substituted α-amino acid derivatives including peptides decorated with pharmacophore pyrimido[1,6-a]indolone core. The method based on tandem C−H activation...
ArtikelCopper‐Catalyzed Cross‐Coupling Reaction of α‐Halo‐N‐Tosylhydrazones with H‐Phosphoryl Compounds to Afford Alkenylphosphoryl Compoundsvon Ruwei Shen et al. · 20.02.2023 C−P bond formation. The copper-catalyzed coupling reaction of α-halo-N-tosylhydrazones with H-phosphoryl compounds is reported to selectively afford alkenylphosphoryl compounds. The reaction with excess H-phosphoryl compounds gave α, N-bisphosphoryl...
Artikel2‐Arylbenzyl Methyl Ethers as Precursors for the Tandem Synthesis of Benzo[c]coumarins Over Heterogeneous Visible‐Light Photoredox Catalysis with Graphitic Carbon Nitride (g‐C3N4)von Palani Natarajan · 20.02.2023 With readily accessible 2-arylbenzyl methyl ethers as precursors, three reactions in one-pot protocol for the synthesis of benzo[c]coumarins over heterogeneous visible-light photoredox catalysis with graphitic carbon nitride is described. This metho...
ArtikelSynthesis, Photophysics and Optical Limiting Properties of Functionalized Benzofuran Derivativesvon Honglin Shang et al. · 20.02.2023 A family of functionalized benzofuran derivatives have been synthesized in this work. Subsequently, the photophysical, electrochemical properties and self-assembly behaviors were examined in detail. Compound 3 b exhibits excellent OL performance bet...
ArtikelBifunctional Platinum‐Incorporated Polyoxoniobate Derived Catalyst for N‐formylation of Piperidine Using CO2von Vorakit Chudatemiya et al. · 20.02.2023 The catalytic properties of alkaline salts of sandwich-type [Pt(Nb6O19)2]12− ((Pt(Nb6)2) were elucidated by N-formylation of amines under CO2 and H2, which resulted in highly selective formamides. After reactions, a formation of Pt nanoparticles and...
ArtikelEfficient Synthesis of Pyrazoles by pH Dependent Isomerization of Enaminodionesvon Jie Lei et al. · 20.02.2023 A chromone-based Michael reaction using water as solvent and nucleophile has been developed to derivatize chromone via a multicomponent reaction (MCR) cascade sequence in absence of a metal catalyst. Abstract A chromone-based Michael reaction usin...
ArtikelConversion of Biomass‐derived Aldehydes using Environmentally Benign CuNi nanocatalystvon Neha Choudhary et al. · 20.02.2023 Bimetallic CuNi nanocatalyst was utilized for biomass derived conversion of aldehydes i. e. furfural, cinnamaldehyde, 5-hydroxy methyl furfural and various ketones into corresponding alcohol with 100 % conversion and 100 % selectivity using 2-propan...
ArtikelAn Efficient Combinatorial Synthesis of Novel Thiazolidinone‐Bis Schiff Base Hybrids Using One‐Pot Multicomponent Reactionvon Anjali Jaiswal et al. · 20.02.2023 A facile multicomponent synthesis of novel thiazolidinone-bis Schiff base hybrids has been developed using readily available starting materials. The four-component reaction of isothiocyanate, hydrazine, aldehyde, and α-bromoester in water readily af...
ArtikelFront Cover: Bifunctional Platinum‐Incorporated Polyoxoniobate Derived Catalyst for N‐formylation of Piperidine Using CO2 (Asian J. Org. Chem. 2/2023)von Vorakit Chudatemiya et al. · 20.02.2023 Formamides are one of the key intermediates in organic syntheses and pharmaceuticals, which are generated from amines and carbonyl sources. The utilization of CO2 as a C1 carbonyl source posts less toxicity than using phosgene or CO, however, the di...
ArtikelEmerging Strategies for Asymmetric Synthesis: Combining Enzyme Promiscuity and Photo‐/Electro‐redox Catalysisvon Chao‐Jiu Long et al. · 20.02.2023 Advances of asymmetric synthesis by combining enzyme promiscuity and photocatalysis or electrosynthesis are highlighted in this Review. The substrate scopes and proposed mechanisms were discussed. Moreover, the development potential of these feature...
ArtikelTransition‐Metal‐Free Methods for the Remote C−H Bond Functionalization of Cyclic Aminesvon Weijie Chen et al. · 20.02.2023 Cyclic amines containing remote C−H bond substitution in the ring are ubiquitous structures in bioactive molecules. To synthesize these compounds, remote C−H bond functionalization of parent aza-heterocycles represents one of the most important stra...
ArtikelProgress of Catalytic Mitsunobu Reaction in the Two Decadesvon Kui Zhang et al. · 20.02.2023 The reaction conditions of the catalytic Mitsunubo reaction are atom-economic and “green”. This review summarizes the advances in the field of the catalytic Mitsunobu reaction during the recent two decades and shed light on the rational design of th...
ArtikelDecade Advance of Isatin in Three‐component Reactionsvon Shuaijie Zhang et al. · 20.02.2023 Isatin is an important building block in organic synthesis. The electron-deficient carbonyl in C-3 site is similar to aldehyde. C-3 carbonyl is also able to function as the O-nucleophile. Devise methodologies about three-component reactions of isati...
ArtikelRecent Advances in the Nickel‐catalysed Electrochemical Coupling Reactions with a Focus on the Type of Bond Formedvon Jisna Jose et al. · 20.02.2023 Recent years have seen a lot of interest in electrochemical metal catalysis as a technology that supports contemporary synthetic chemistry. Nickel can be used effectively in metal-catalysed electrochemical reactions due to its inexpensive nature, hi...
ArtikelSynthesis of CF3, CF2H‐Substituted, Epoxide‐Fused Heterocycles with Prop‐2‐ynylsulfonium saltsvon Shitong Wu et al. · 18.03.2023 A [4+2]/[2+1]-annulation reaction was developed of prop-2-ynylsulfonium salt and o-amino trifluoroacetophenone and difluoroacetophenone derivatives, forming CF3-substituted epoxide fused quinolones and CF2H-substituted epoxide fused quinolones in mo...
ArtikelHomemade Solution of NaOD in D2O: Applications in the Field of Stilbene‐d1 Synthesisvon Keisuke Imai et al. · 18.03.2023 Although NaOD in D2O is a valuable chemical reagent to prepare the deuterium-incorporated products, it costs high. The cover picture shows that the simple and cost-effective preparation of NaOD in D2O from D2O and t-BuONa was accomplished based on t...
ArtikelN ‐Heterocyclic carbene‐catalyzed condensation/oxidation/cyclization/aromatization cascade for the synthesis of tri‐ and tetra‐substituted imidazolesvon mohsen khataminejad et al. · 17.03.2023In this study, a novel and efficient one-pot tandem synthesis of 2,4,5-tri- and 1,2,4,5-tetra-substituted imidazoles is described. In the first step of the sequence, benzil is formed via benzoin condensation catalyzed by N-heterocyclic carbene, follo...
ArtikelCatalyst‐ and Light‐free S‐H Insertion between Phosphorodithioic Acids and Diazo Compounds: Rapid Access to Dialkylphosphorodithioatesvon Meiling Huang et al. · 17.03.2023A catalyst- and light-free S-H insertion of phosphorodithioic acids with diazo compounds has been developed, in which phosphorodithioic acid acts not only as an acid promoter but also as a nucleophile. This protocol features fast reaction rate, broad...
ArtikelSelective Synthesis of Benzofuro[2,3‐c]isoquinolines and 5,6‐Dihydro‐7H‐benzo[c]benzofuro[2,3‐e]azepin‐7‐ones from 4‐Diazoisoquinolin‐3‐ones and Salicylaldehydesvon Junrong Chen et al. · 17.03.2023 Biologically valuable benzofuro[2,3-c]isoquinolines and 5,6-dihydro-7H-benzo[c]benzofuro[2,3-e]azepin-7-ones were synthesized through the metal-catalyzed cascade reaction between 4-diazoisoquinolin-3-ones and salicylaldehydes. The reaction furnished...
ArtikelConstruction of bis‐indole derivatives using α‐amylase enzyme: Application in the gram‐scale synthesis of bis‐indole containing bioactive moleculesvon Priya Kamboj et al. · 16.03.2023Herein, we have developed a biocatalytic approach toward the synthesis of bis(indolyl)methane using an α-amylase in water. This protocol has a number of advantages like eco-friendly reaction conditions, use of biodegradable catalyst, and higher conve...
ArtikelDFT Studies on Ligand Controlled Highly Selective Copper‐Catalyzed Borylations of Allenesvon Shichao Hong et al. · 16.03.2023 The mechanism of Cu-catalyzed borylations of allenes has been studied by DFT calculations. The γ-protonolysis is both the rate-limiting and the regioselectivity-determining step. When using P(p-OMeC6H4)3 as ligand, the regioselectivity is governed b...
ArtikelAsymmetric Mannich/Radical Debromination Cascade of α‐Bromoketones by Dipeptide‐Phosphonium Salt Catalysis: Enantioselective Synthesis of β‐Amino Ketone‐Pyrazolinonesvon Jixing Che et al. · 16.03.2023 An efficient and practical method towards asymmetric synthesis of chiral β-amino ketone-pyrazolinone compounds has been developed, which was enabled by dipeptide-phosphonium salt-catalyzed Cascade reaction bearing a radical pathway. With this cataly...
ArtikelIodine‐ and Bromine‐Promoted Transformations of Pyridotriazoles: General Access to Geminal Diiodo and Dibromo Methylpyridinesvon Tao Tang et al. · 15.03.2023 Geminal diiodo and dibromo methylpyridines were obtained in moderate to good yields when pyridotriazoles were treated with iodine and bromine under mild conditions. Abstract A new ring-opening method for pyridotriazole was developed. Geminal diiod...
ArtikelDesign and Synthesis of Nitro Cage Heterocycles as Energetic Materials Derived from Pentacycloundecane (PCUD) Systemsvon Sambasivarao Kotha et al. · 14.03.2023 Various pentacycloundecane (PCUD) derivatives were synthesized, characterized and a detailed computational insight into their energetic properties, using DFT-based calculations, was carried out. The densities of these compounds 11 b–18 b ranged from...
ArtikelMetal‐Free Iodine‐Catalyzed Oxidative Dehydrogenation of N‐Heterocyclesvon Dengke Li · 14.03.2023 A general and straightforward iodine-catalyzed oxidative dehydrogenation system of saturated N-heterocycles for the synthesis of N-heteroarenes is investigated. In this protocol, a series of indole, (iso)quinoline, β-carboline analogues could be ach...
ArtikelMn(acac)3 as a Remarkably Efficient Oxidant: Mediation of the Radical Addition/Cyclization Cascade of Boronic Acids with Isocyanidesvon Xiao‐Feng Wang et al. · 14.03.2023 A Mn(III)-mediated radical cascade reaction of isocyanides and boronic acids to access 3-aminoquinoline derivatives is described. The difference in reactivity of the two manganese salts was detailed investigated and interpreted. Abstract A remarka...
ArtikelTransition‐Metal‐Free α‐C‐Alkylation of Oxindoles with Alcoholsvon Yu‐Tong Duan et al. · 14.03.2023 Transition-metal-free reaction of oxindoles with primary or secondary alcohols in the presence of LiOtBu affords α-C-alkylated oxindoles. Abstract Transition-metal-free α-C-alkylation of oxindoles with alcohols was performed. The reaction requires...
ArtikelHigh‐performance Supercapacitors Enabled by Highly‐porous Date Stone‐derived Activated Carbon and Organic Redox Gel Electrolytevon Abubakar et al. · 14.03.2023Construction of eco-benign, cost effective, and high-performance supercapacitors with improved electrolytes and hierarchical porous electrodes is necessary for effective energy storage. In this study, a gel type organic redox electrolyte made of poly...
ArtikelMacrocyclization Strategies Towards the Synthesis of Amphidinolide Natural Productsvon Bhaskar Chatterjee et al. · 14.03.2023 This review presents a comprehensive summary of the literature covering the last two decades for synthesising the unique macrocyclic framework of potent cytotoxic amphidinolides via intramolecular C−C and C−O bond-forming reactions. Abstract dinof...
ArtikelMetal‐Free Iodine‐Promoted Oxidative Dehydrogenative Aromatization of Pyrazolidin‐3‐ones and Pyrazolines: An Efficient and Practical Approach to Functionalized Arylpyrazolesvon Dengke Li et al. · 14.03.2023 An efficient and practical iodine-promoted oxidative aromatization of pyrazolidin-3-ones and pyrazolines has been developed under metal-free, additive-free and external-oxidant-free conditions in good yields with a broad functional group tolerance. ...
ArtikelSynthesis of triazolo[c]coumarins and differences in the fluorescence properties of their isomersvon Miyu Sekine et al. · 13.03.2023Despite the simple structures of 3,4-fused tricyclo coumarins, their fluorescence properties have not been studied extensively. We have synthesized triazolo[c]coumarins using Huisgen cycloaddition and investigated their fluorescence properties. The H...
ArtikelRecent Development in the Catalytic Applications of Pd‐NHC (NHC = N‐Heterocyclic Carbene) Compounds in Amide C–N Activation Reactionsvon Han Shao et al. · 13.03.2023Palladium-catalyzed C–N bond activation of amide is a important but very challenging research area in organic chemistry. This reaction represents a powerful and straightforward method for the preparation of various carbonyl compounds under mild react...
ArtikelCopper‐Catalyzed Tandem Cyclization Approach to N, O‐Chelated Boron Difluoride Complexesvon Zemin Cheng et al. · 11.03.2023A strategy for the synthesis of N,O-chelated boron difluoride complexs via copper-catalyzed tandem cyclization of easily available 2-aryl pyridines has been developed. This reaction tolerates a wide range of functional groups, providing the correspon...
ArtikelSynthesis of 1,2,4‐triazoles and 1,3,4‐thiadiazinones by [3+2] and [3+3] domino annulation reactions of nitrile imines with succinimide and thiazolidine‐2,4‐dionevon Sai et al. · 10.03.2023Herein we report protocols for the synthesis of 1,2,4-triazoles and 1,3,4- thiadiazinones by [3+2] and [3+3] domino annulation reactions of nitrile imines with succinimide and thiazolidine-2,4-dione, respectively, using a base (1.5 equivalents) and a...
ArtikelQuantum‐Chemical Insight into Self‐Organization of Complex Molecules from Acetylene and Anilines Catalyzed by Superbase KOH/DMSO: One‐Pot Cascade Assembly of 1,3‐Bis(arylamines)von Damir Z. et al. · 09.03.2023 The one-pot formation of 1-acetyl-1,3-bis(arylamines) from three molecules of acetylene and two molecules of haloanilines in the KOH/DMSO system was studied quantum-chemically. The results predict cascade-like character of the assembly, with each ne...
ArtikelSolid‐Supported Catalysts for Organic Functional Group Transformationsvon Sodiq Adeyeye et al. · 09.03.2023 This review highlights major advancements in solid-supported metal catalysts. A series of reactions, such as hydrogenation, carbon-carbon bond formation, and oxidation reactions, and the effect of variable supports towards activity and selectivity a...
ArtikelA compilation of multicomponent approaches involving carbon disulfidevon Mayur et al. · 08.03.2023In present scenario, innovative carbon disulfide-involving multicomponent protocols are extremely advantageous for practical and efficient construction of acyclic as well as heterocyclic building blocks. Carbon disulfide is well recognized synthetic ...
ArtikelIodine catalysed oxidative cross coupling of thioureas and amines without desulfurizationvon Lavina Gladis et al. · 08.03.2023Iodine/tert-butyl hydroperoxide (TBHP) mediated synthesis of sulfenamides via oxidative cross coupling of thioureas and amines without desulfurization is developed. Diversely substituted sulfenamides have been synthesized in moderate to good yields i...
ArtikelProgress in the Electrochemical Synthesis of Organoboron Compoundsvon Mohammad Moniruzzaman et al. · 08.03.2023Organoboron is a class of compounds widely used in organic synthesis, pharmaceuticals, material science, sensors, and so on. Therefore, the development of efficient and selective electrochemical methods to synthesize organoboron has attracted much in...
ArtikelBlue‐Emitting 2‐Fluoroaryl‐1,2,3‐Triazole Fluorophores: Synthesis, Theoretical Calculations, and Optical Propertiesvon Igor A. et al. · 06.03.2023 A convenient five-step synthetic strategy affords novel push-pull fluorophores based on N(2)-fluoroaryl-1,2,3-triazoles to be of interest as functional blocks in the design of advanced blue-emitting organic materials. Abstract A convenient multist...
ArtikelStrategies towards the Synthesis of 2‐Ketoaryl Azole Derivatives using C‐H Functionalization Approach and 1,2‐Bis‐Nucleophile Precursorsvon Nayyef AlJaar et al. · 03.03.2023A spectrum of compounds embedded with 2-keto aryl azole moieties are found as pivotal building blocks in medicinal chemistry and drug discovery. This is why, the collection of novel methods have been described for the synthesis of these compounds, wh...
ArtikelTrichloroisocyanuric acid (TCCA): A Suitable Reagent for Direct Glycosylations of C1‐Hemiacetals with Different Nucleophilesvon Ariza Khanam et al. · 01.03.2023 Trichloroisocyanuric acid (TCCA), a readily available in combination with PPh3, has been used for dehydrative glycosylation reactions of C1-hemiacetals. This reaction protocol is considered by a broad substrate scope with high yields, including reac...
ArtikelAsymmetric Direct Vinylogous Conjugate Addition of α,β‐Unsaturated γ‐Butyrolactam to Acyl Acrylonitriles using Organocatalystsvon Daiki Ishii et al. · 28.02.2023Thiourea organocatalyst efficiently promotes the asymmetric direct vinylogous conjugate addition of α,β-unsaturated γ-butyrolactam to benzoyl acrylonitriles, resulting in corresponding addition products with good yields and excellent stereoselectivit...
ArtikelDirect Irradiation of (E)‐Styrylpyridin‐2(1H)‐ones to (Z)‐Isomers with Visible Lightvon Jingzhi Sui et al. · 27.02.2023 An approach for the E to Z isomerization of styrylpyridin-2(1H)-ones via visible light irradiation at ambient temperature has been developed. This protocol has the advantages of avoiding use of photocatalysts and additives, direct irradiation using ...
ArtikelMulticomponent Selective Thioetherification of KSAc: Easy Access to Symmetrical/Unsymmetrical 4‐Alkylthio‐3‐halo‐2(5H)‐furanonesvon Yong‐Jun Zhou et al. · 24.02.2023 A transition metal-free catalyzed synthesis of symmetrical/unsymmetrical 4-alkylthio-3-halo-2(5H)-furanones has been developed. The reaction without any metal catalyst or additive is carried out in air atmosphere at room temperature for 5 h only usi...
ArtikelIntraspecific Variation in the Terpene Profiles of Dodonaea viscosavon Adriana Dutra-Nobre et al. · 24.02.2023Natural products isolation studies were performed on Dodonaea viscosa plant individuals sampled across seven different populations, which revealed considerable intraspecific variation in the terpene profiles across D. viscosa. In total, 14 ent-labdan...
ArtikelCalcium Aluminate Induced Pt(0)‐Pt(δ+) Coupling Boost Catalyzed H−D Exchange Reaction of Arenes with Deuterium Oxidevon Wenjie Jiang et al. · 22.02.2023 Pt/Ca12Al14Ox is a highly efficient catalyst that exhibits outstanding catalytic deuteration performance for toluene in D2O and hydrogen environments. The excellent catalytic performance comes from the Pt(δ+) and Pt(0) components involved, which act...
Artikel4‐Chloro‐2‐azaadamantane N‐Oxyl (4‐Cl‐AZADO): A Readily Preparable Organocatalyst for NOx Co‐catalyzed Aerobic Alcohol Oxidationvon Shota Nagasawa et al. · 17.02.2023 4-chloro-2-azaadamantane N -oxyl (4-Cl-AZADO) enabled upon coupling with NOx an efficient, transition-metal-free aerobic oxidation of alcohols. 4-Cl-AZADO is easily preparable in multigram-scale and posesses high catalytic activity compared wit...
ArtikelA TfOH‐Catalyzed Multicomponent Reaction of Propargylic Alcohols, Sulfonamides and Aldehydes for the Synthesis of Acyclic α‐Arylidene β‐Aminoketonesvon Tiantian Li et al. · 16.02.2023 A multicomponent reaction process involving propargyl alcohols, sulfonamides and aldehydes and giving α-arylidene-β-aminoketones was investigated. The sulfonimides generated in situ in this process act as electrophilic intercepted reagents during th...
ArtikelCopper‐Catalyzed Synthesis of β‐Alkynyl Ketones from Propargylic Alcohols and Enamidesvon Yucheng Wang et al. · 16.02.2023 Synthetic strategy involving a Cu(OTf)2-catalyzed coupling of propargylic alcohols and enamides for the synthesis of β-alkynyl ketones was developed. The reaction exhibits good functional-group tolerance and broad substrate scope. Abstract An effi...
ArtikelABNO‐Catalyzed Aerobic Oxidation of Thiols to Disulfides under Atmospheric Pressurevon Zhiguang Zhang et al. · 16.02.2023 An ABNO-catalyzed aerobic oxidative coupling reaction of benzylic thiols and aliphatic thiols afforded various disulfides in good to excellent yields under mild condition with H2O as sole byproduct. Using molecular oxygen at ambient pressure as term...
ArtikelVisible‐Light‐Mediated Direct Expeditious Photochemical Construction of Spirocyclic‐oxindolesvon Biplob Borah et al. · 14.02.2023 This review article highlights the recent advances accomplished in the construction of spirocyclic oxindoles based on the visible light accelerated photochemical activation method. Abstract Spirocyclic compounds, particularly spirooxindoles that c...
ArtikelSolvent‐Free Synthesis of Substituted Benzimidazoles and Quinazolinones via Acceptorless Dehydrogenative Coupling Using Ferrocene‐Hydrazone‐Based Ru(II)‐p–cymene Catalystsvon Aswathi Ravindran et al. · 14.02.2023 Ru(II)-p-cymene complexes containing ferrocene-hydrazone ligands were employed as catalysts for the selective synthesis of 1,2-disubstituted benzimidazoles and 2-substituted quinazolinones via acceptorless dehydrogenative coupling, with hydrogen and...
ArtikelEfficient Synthesis of α‐P‐Modified Nucleoside Triphosphates and Dinucleoside Tetraphosphates via Linear PVPVPIII‐Nucleoside Intermediatesvon Ying‐Ying Dong et al. · 10.02.2023 A novel and efficient method for synthesis of α-P-modified nucleoside triphosphates and dinucleoside tetraphosphates via linear PVPVPIII-nucleoside intermediates has been developed. Abstract As an important class of nucleoside triphosphate analogu...
ArtikelDirect Aldimine Oxidative Reaction: A General Approach toward Amidesvon Qing‐Peng Liu et al. · 10.02.2023 The first procedure to directly access amides from stable imine under potassium peroxymonosulfate (Oxone)/DMF system was reported. It involved a nucleophilic addition of imine with Oxone, a similar Baeyer-Villiger rearrangement and a tautomerization...
Artikel[1,2]‐Phospha‐Brook Rearrangement as Tool for Generation of Anionic Nucleophiles in Addition Reactions under Brønsted Base Catalysisvon Azusa Kondoh et al. · 08.02.2023 The [1,2]-phospha-Brook rearrangement involves the migration of the dialkoxyphosphoryl moiety of the alkoxide of an α-hydroxyphosphonate from carbon to oxygen to generate an α-oxygenated carbanion. This review article focused on the recent developme...
ArtikelUnprecedented Regioselective Deuterium‐Incorporation of Alkyltrimethylammonium Chlorides and Raman Analysisvon Yoshinari Sawama et al. · 04.02.2023 Dodecyltrimethylammonium chloride (DTAC), as a representative ATAC, underwent the regioselective multi-deuteration of alkylamine moiety, except for α and β-positions. Deuteration was performed under Pt/C and Ru/C-catalyzed conditions in 2-PrOH and D...
ArtikelSynthesis and Studies of Dibenzofuran Embedded Bis‐(Calix)‐Pentaphyrinsvon Shubham Tiwari et al. · 04.02.2023 The dibenzofuran (DBF) embedded bis-(calix)-pentaphyrin macrocycles were synthesized by [3+2] condensation strategy. The macrocycles were non-aromatic due to interruption of conjugation because of the presence of two meso-sp3 centres. Abstract Con...
ArtikelRobinson Annulation Applied to the Total Synthesis of Natural Productsvon Majid M. et al. · 02.02.2023 The Robinson annulation is a significant reaction for the synthesis of α,β-unsaturated ketone ring including the generation of two C−C bonds. It involves a Michael addition of a ketone and a methyl or ethyl vinyl ketone with subsequent intramolecula...
ArtikelA Highly Active Palladium System Catalyzed C2‐Arylation of N‐Acyl Pyrroles with Aryl Halides and Their Biological Activityvon Weiqiang Chen et al. · 01.02.2023 The formation of C−C bonds is a fundamental bond construction in organic synthesis. In this study, a highly active palladium catalytic system has been developed for the C2-arylation of N-acyl pyrroles with aryl halides in the help of copper additive...
ArtikelCobalt‐Catalyzed Diastereo‐ and Enantioselective Hydroarylation of Cyclopropenes with Arylboronic Acidsvon Jiwu Zhang et al. · 01.02.2023 Diastereo- and enantioselective hydroarylation of cyclopropenes catalyzed by an easily accessible Co complex was developed through a new method. This protocol represents a complementary approach that enables introduction of a wide range of aryl unit...
ArtikelZwitterion‐Catalyzed Ring‐Opening of Epoxides with Carboxylic Acidsvon Shengsheng Qiang et al. · 28.01.2023 The amide/phosphonium zwitterionic organocatalyst is useful to catalyze epoxide ring-opening with carboxylic acids to give 1,2-diol monoesters. Other than epoxide, aziridine can also be used in the reaction. Various valuable building blocks can be p...
ArtikelVisible‐Light Induced Oxidative Annulation of Enamides to 2,4,5‐Trisubstituted Oxazole Skeletonsvon Dan‐Ning Wang et al. · 28.01.2023 An alternative access to 2,4,5-trisubstituted oxazoles via photoinduced oxidative annulation of enamide was developed by employing 9H-thioxanthen-9-one as the photocatalyst and PhNO2 as electron-acceptor in the presence of BF3 ⋅ Et2O under mild cond...
ArtikelContinuous Flow Synthesis of Non‐Symmetrical Ureas from CO2von Alexandre Labiche et al. · 21.01.2023 A continuous flow synthesis of non-symmetrical ureas, based on the implementation of the Staudinger/aza-Wittig reaction sequence is reported. The potential for large-scale reactions was demonstrated and a first application to 13C-isotope labeling wa...
ArtikelPlatinum‐Catalyzed Facile Arene Hydrogenation: Dramatic Effect of Activated Carbon and Vinylsiloxane Derivatives on the Catalyst Efficiencyvon Yukihiro Motoyama et al. · 17.01.2023 Activated carbon was found to act as an efficient additive for sustaining the catalytic activity and removing metallic species after the reaction in the arene hydrogenation of substituted aromatic compounds over Karstedt's catalyst and Pt(dba)2. A...
ArtikelRuthenium‐Catalyzed Selective B(4)‐H Amidation of o‐Carboranes with Dioxazolonesvon Heejin Yang et al. · 10.01.2023 A ruthenium-catalyzed selective B4 amidation of o-carboranes with a variety of alkyl-, aryl-, and heteroaryl-substituted dioxazolones is developed by carboxylic acid-assisted B(4)-H bond activation in o-carborane acids, affording a multitude of (4)-...
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