Fachzeitschriften

Asian Journal of Organic Chemistry

Artikel

Cover Feature: Ligand‐Induced Selectivity in the Reaction of Conjugated Enyne with Enolic Ester: A DFT‐Based Mechanistic Study (Asian J. Org. Chem. 8/2025)

von Shivangi Gupta et al.

· 14.08.2025

The cover image illustrates a reaction where two reactants react in the presence of the palladium catalyst via divergent pathways depending on the ligand environment. The presence of different ligands (L1 and L2) directs the catalytic cycle through ...

Artikel

Front Cover: Planar, Twisted, and Curved π‐Extended Pyrrolo[3,2‐b]Pyrroles: Recent Advances in Synthesis, Properties, and Applications (Asian J. Org. Chem. 8/2025)

von Seyed Parsa et al.

· 14.08.2025

This cover blends the core concept of review e202500565 by Mohammad Bagher Teimouri and co-workers with elements of Iranian culture. The unique 3D architecture of pyrrolo[3,2-b]pyrroles is reflected in the curved forms of the clouds and the warped f...

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Nitrogen Isotope Exchange (NIE): Opportunities and Challenges

von Guoqing Wang et al.

· 14.08.2025

Nitrogen atom extensively exits in pharmaceutical, natural products and functional materials. Nitrogen-14 is the most abundant isotope of nitrogen while nitrogen-13 and nitrogen-15 are two other important isotopes. Compounds including nitrogen-15 or...

Artikel

Synthetic Approaches to Chalcone Synthesis

von Fatemeh Doraghi et al.

· 14.08.2025

Chalcones are extensively found in natural products and are applied in medical science and other technologies. For the reactivity in organic chemistry, chalcones are used as significant building blocks and intermediates in organic synthesis. Hence, ...

Artikel

Progress on Glycosidation via Radical Strategy

von Wen Tian et al.

· 14.08.2025

The glycation reaction via the radical pathway not only addresses the pain points of traditional methods in selectivity, efficiency, and compatibility but also provides an innovative tool for the cross-research of sugar science, life science, and ma...

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Propelling Chan‐Lam Cross‐Coupling Through Photocatalysis and Electrocatalysis: An Update

von Rakhee Saikia et al.

· 14.08.2025

In recent years, the classical modus operandi of Chan-Lam cross-coupling has seen a paradigm shift to contemporary modes like visible-light photocatalysis and electrocatalysis. These techniques can bring about improved transformations compared to th...

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Enantiopure Chiral Crystals: A Powerful Tool for Absolute Asymmetric Synthesis

von Jiacheng Li et al.

· 14.08.2025

This review covers absolute asymmetric syntheses, which allow the preparation of enantiomerically enriched chiral compounds from achiral precursors. By exploiting the crystallization of certain compounds as a conglomerate, enantiopure chiral crystal...

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Alcohols in the Synthesis of Bis(indolyl)methanes and C3‐Alkylated Indoles: Recent Advances and Challenges in Homogeneous Catalysis

von Sandip Bapu et al.

· 14.08.2025

This review explores the innovative strategies for synthesizing bis(indolyl)methanes and C3-alkylated indoles using alcohols as green alkylating agents. Focusing on borrowing hydrogen (BH) and interrupted BH pathways, we highlight the role of transi...

Artikel

Iron Photocatalysis for C─H Functionalizations

von Silvia Cattani et al.

· 14.08.2025

We report the latest advances in photo-assisted, iron-catalyzed C─H functionalization reactions. This emerging field of research showed high potential in the formation of new C─C and C─Het bonds and late-stage functionalizations of pharmaceuticals a...

Artikel

Electro‐Organic Synthesis of Heterocyclic Compounds

von Chilumula Sushma et al.

· 14.08.2025

Electrochemical reactions are conducted under remarkably mild conditions within an electrochemical cell, thereby rendering the processes environmentally sustainable and greener. This comprehensive review provides an overview of electrochemical organ...

Artikel

Structural Engineering of Platinum‐Containing Organic Photovoltaic Catalysts for Solar‐Driven Hydrogen Production: A Review

von Jianan Fan et al.

· 14.08.2025

Photocatalysts based on organic photovoltaic donor/acceptor (D/A) heterojunctions have demonstrated exceptional photocatalytic hydrogen evolution activity. This review discusses recent advancements in the molecular structural engineering of high-per...

Artikel

Emerging Strategies in N‐Fluoroalkylation: Recent Progress

von Chunpeng Li et al.

· 14.08.2025

Abstract The strategic introduction of fluorine to the α-carbon of amine compounds enables precise electronic modulation of nitrogen-centered charge distribution, thereby modifying the molecular spatial configuration and physicochemical propert...

Artikel

Recent Advances in the Trifluoromethylselenofunctionalization of C─C Multiple Bonds: Synthesis of Vicinally Functionalized CF3Se‐Containing Compounds

von Ying Chen et al.

· 14.08.2025

Trifluoromethylselenofunctionalization of carbon-carbon multiple bonds have significantly expanded the synthetic toolbox for preparing vicinally functionalized CF3Se-containing compounds. This emerging methodology enables the efficient introduction ...

Artikel

Planar, Twisted, and Curved π‐Extended Pyrrolo[3,2‐b]Pyrroles: Recent Advances in Synthesis, Properties, and Applications

von Seyed Parsa et al.

· 14.08.2025

This artwork captures the π-expansion evolution of pyrrolo[3,2-b]pyrroles from 2013 to 2024. Key structures are positioned as clock hours based on their synthesis year. Around the dial, three commonly used reactions and their contributions are highl...

Artikel

Dearomatization of Aromatic Compounds: A Decade Review

von Jiangfei Chen et al.

· 14.08.2025

Dearomatization offers an efficient strategy for directly converting arenes into cyclic molecules. In this review, we discuss representative examples of dearomatization reactions through five modes: (1) radical dearomatization, (2) halofunctionaliza...

Artikel

Quantum‐Chemical Modeling of One‐Pot Assembly of 1‐Formyl‐2‐Pyrazolines from Alkylaryl Ketones, Arylacetylenes, Hydrazine, and Formic Acid

von Vladimir B. et al.

· 14.08.2025

The assembly mechanism of 1-formyl-2-pyrazoline from acetophenone, phenylacetylene, hydrazine and formic acid was studied using quantum-chemical methods. Two synthetic stages were considered: (i) the interaction of acetophenone and phenylacetylene w...

Artikel

Ligand‐Induced Selectivity in the Reaction of Conjugated Enyne with Enolic Ester: A DFT‐Based Mechanistic Study

von Shivangi Gupta et al.

· 14.08.2025

The reaction of conjugated enyne with enolic ester is demonstrated. A DFT-based mechanistic study is conducted to determine the mechanism leading to 6-endo-trig and 5-exo-trig products with L1 and L2 ligands, respectively. Distortion/interaction ana...

Artikel

The Application of Hangman Fe(IV) Corrole in the Baeyer–Villiger Oxidation Reaction

von Yi‐Feng Qiu et al.

· 14.08.2025

A series of new hangman iron corroles with different electronic structure and pending aldehyde group were prepared and used as catalyst in B–V oxidation reactions. The results show that hangman iron corroles exhibit faster reaction rates and higher ...

Artikel

Nickel(II) Chloride Catalyzed and Tetrahydroxydiboron Promoted Denitrative Difluoroalkylation of β‐Nitrovinylarene

von Siyi Zhong et al.

· 14.08.2025

A novel denitrative cross-coupling reaction between β-nitrostyrene and ethyl bromodifluoroacetate (or their derivatives) has been successfully achieved, utilizing nickel(II) chloride and tetrahydroxyboron as catalysts. The current method exhibits ex...

Artikel

Large‐Scale Chemoenzymatic Synthesis of a Glycophorin A Tetrasaccharide Motif and Its Analogues

von Ivan A. et al.

· 14.08.2025

A large-scale chemoenzymatic method was developed to synthesize natural and modified analogues of the Glycophorin A tetrasaccharide with either C9 or C5 terminal α-2,3-sialic acid variants. Selective α-2,6-sialylation of galactosamine was achieved b...

Artikel

Hyper‐Crosslinked Imidazole Polymers for High‐Efficiency Adsorption of Congo Red in Wastewater

von Chancui Wu et al.

· 14.08.2025

The hyper-crosslinked imidazolium polymer adsorbent, synthesized through the Friedel-Crafts alkylation reaction, possesses high specific surface area, a porous structure, and is rich in phenyl and imidazole groups. This adsorbent exhibits high adsor...

Artikel

Microwave‐Assisted Rapid and Efficient Synthesis of Novel Indazole‐Based 1,3,4‐Oxadiazole Derivatives with Molecular Docking, ADME, and DFT Studies

von Bandaru Gopi et al.

· 14.08.2025

A novel microwave-assisted method for synthesising indazole-1,3,4-oxadiazoles was developed using both aromatic and aliphatic carboxylic acids. The structural characterisation of the compounds was performed using IR, NMR, and HRMS. The photophysical ...

Artikel

Grindstone Telescopic Approach for Pyrrolodiazepines Through Pictet‐Spengler‐Type Reaction and Solvent‐Free Synthesis of Quinazolines

von Maitreyee Panda et al.

· 14.08.2025

We have established Pictet-Spengler-type telescoping strategy under eco-friendly, cost effective, and energy efficient mechanochemical activation for the first time to construct pyrrolodiazepines and quinazolines in moderate to excellent isolated yi...

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Efficient Transition Metal‐Free Potassium Persulfate Promoted Regioselective Ketonization of Vinyl Azides: Advancing α‐Thiocyanated Ketones Synthesis

von Santosh Sing et al.

· 14.08.2025

In this method, selective synthesis of α-thiocyanate and α-selenocyanate ketones has been reported by metal-free ketonization of vinyl azides with potassium persulfate. The room temperature process enhances sustainability, offering a greener more ef...

Artikel

Synthesis and Photochromism of 2H‐Naphthopyrans With an Extended Conjugation Skeleton

von Xi Tu et al.

· 14.08.2025

A new type of 2H-naphthopyran derivatives─benzonaphthopyrans (BNP) and naphthonaphthopyran (NNP)─have been synthesized, and their photochromic properties have been investigated in detail. We discovered that the extended conjugation skeleton could si...

Artikel

Ir‐Catalyzed Sulfur‐Directed Vinylic C─H Activation for the Stereoselective Synthesis of 1,3‐Dienes Using Alkynoates

von Takanori Shibata et al.

· 14.08.2025

Ir-catalyzed sulfur-directed C─H alkenylation of alkynoates proceeded by using aryl methallyl sulfides. When DMAD was employed, 1,3-dienes were initially formed and subsequently underwent thermal 1,5-sigmatropic rearrangement to yield secondary prod...

Artikel

Nickel‐Catalyzed Synthesis of Structurally Diverse N‐(hetero)aryl Pyrroles

von Chitrarekha Dewangan et al.

· 14.08.2025

We report a simple protocol for the preparation of functionalized pyrroles employing 2,5-hexandione or succinaldehyde and anilines as starting materials in the presence of a well-defined homogeneous nickel catalyst (NiCl₂·6H₂O + dppe). Abstract P...

Artikel

BOPHY Dyes Bearing Arylsulfenyl Moieties as Highly Efficient Triplet Photosensitizers

von Julieth Bellaizac‐Riascos et al.

· 14.08.2025

A new set of symmetric BOPHY dyes has been successfully applied in photoinduced processes acting as triplet photosensitizers. They have been used not only in bimolecular systems for photon upconversion based on triplet-triplet annihilation but also ...

Artikel

DMAP‐Catalyzed [4 + 3] Spiroannulation of Ninhydrin‐Derived MBH Carbonates with Acyclic Azadienes: Efficient Access to Multisubstituted Spiro[indanone‐azepine] Scaffolds

von Xiang‐Hong He et al.

· 14.08.2025

An efficient DMAP-catalyzed [4 + 3] annulation of ninhydrin-derived MBH carbonates with acyclic azadienes was developed, providing a series of polysubstituted, pharmacologically interesting spiro[indanone-azepine] derivatives in good to excellent yi...

Artikel

Transition Metal‐Free Synthesis of 3‐Aryl‐4‐Cyano Isocoumarin Derivatives with 2‐Cyanomethyl Aroyl Fluorides and Their Applications

von Serin Hong et al.

· 14.08.2025

Synthesis of 3-aryl-4-cyano isocoumarins from 2-cyanomethyl aroyl fluorides was investigated. After deprotonation of cyanomethylene group in aroyl fluorides, sequential acyl substitution and intramolecular cyclization provided isocoumarins in excell...

Artikel

Synthesis of Dibenzopyranones via Visible Light‐Mediated Pd‐Catalyzed Esterification/C─H Activation Cascade

von Padon Chuentragool et al.

· 14.08.2025

A series of of 6H-benzo[c]chromen-6-one derivatives were prepared via a Pd-catalyzed cross-coupling reaction of o-bromo benzoic acids and aryl formates using light-irradiation at room temperature. Preliminary studies on the reaction mechanism indica...

Artikel

Nickel‐Catalyzed Carbonylative Cross‐Electrophile Aryl Alkyl Ketones Synthesis with CO2 as a CO Surrogate

von Meijuan Lin et al.

· 14.08.2025

A Ni-catalyzed carbonylative cross-electrophile coupling of aryl iodides and alkyl bromides has been successfully developed with CO₂ as a CO surrogate. The reaction provides an efficient method for the construction of a wide range of valuable aryl a...

Artikel

I2/DMSO Mediated [5+1] Oxidative Annulation of Aryl Methyl Ketones with 2‐(2H‐Indazol‐2‐yl)anilines for the Synthesis of Indazoloquinoxalines

von Mariyaraj Arockiaraj et al.

· 14.08.2025

A metal-free, iodine-mediated protocol has been established for the synthesis of indazoloquinoxaline derivatives using readily accessible substrates. This methodology provides a straightforward route to diverse indazoloquinoxaline derivatives, achie...

Artikel

Synthesis of a BINOL‐Derived Sulfide Catalyst Bearing a Diphenylmethanol Unit and Its Application in Asymmetric Bromolactonizations

von Yasuaki Furuya et al.

· 14.08.2025

The excellent catalytic performance of a BINOL-derived sulfide catalyst bearing a diphenylmethanol unit was demonstrated in the highly enantioselective synthesis of γ-butyrolactones via bromolactonization. Abstract A BINOL-derived sulfide catalys...

Artikel

Solvent‐Directed Handedness in a Chirally Twisted Tetrakisporphyrin Macrocycle

von Kouta Tanabe et al.

· 14.08.2025

A chirally twisted tetrakisporphyrin macrocycle was synthesized by incorporating a chiral dioxolane into a tetrakisporphyrin macrocycle. The solvent type influenced the preferred handedness of the twisted conformation. Circular dichroism measurement...

Artikel

Synthesis and Characterization of Chiral Porphyrin Derived from (–)‐α‐Phellandrene

von Rui Ichiryu et al.

· 14.08.2025

Chiral pyrrole and porphyrin: A diastereomerically pure chiral pyrrole was synthesized in the reaction of ethyl isocyanoacetate and a bicyclic Diels–Alder adduct from naturally occurring (−)-α-phellandrene and 1,2-bis(phenylsulfonyl)ethene. The unid...

Artikel

Interrupted Barton–Zard Reaction/Friedel–Crafts Alkylation Telescoped Reaction for the Synthesis of Pyrrolo[3,4‐b]indole Cores

von Josip Rešetar et al.

· 14.08.2025

An interrupted Barton–Zard reaction/Friedel–Crafts alkylation telescoped reaction provides aryl-substituted pyrrolo[3,4-b] cores in moderate-to-good yields as mostly single diastereomers. The reaction is tolerant of a wide range of electron-deficien...

Artikel

Palladium Nanoparticles Dispersed in Alginate Beads as an Efficient, Eco‐friendly, and Sustainable Heteregeneous Catalyst: Testing in Carbon‐Sulfur and Carbon‐Carbon Cross‐Coupling Reactions

von Ramesh Katla et al.

· 14.08.2025

Abstract The development of sustainable and efficient catalysts featuring palladium nanoparticles (Pd NPs) is highly sought after. In this context, sodium alginate, a natural polymer, presents a promising eco-friendly support material for Pd NP...

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Efficient Catalytic Condensation of Methyl Ketones with Indole to Form All‐Carbon Quaternary Center Bisindolylmethanes Mediated by Strong Dual Brønsted Acid

von Wan‐Ying Xu et al.

· 14.08.2025

A dual Brønsted acid catalyst (1a) with perfluorobutylsulfonimide groups synthesizes bisindolylmethanes (BIMs) bearing all-carbon quaternary centers. Methanol enables 59%–99% yields (30 °C), with acetophenone showing >90% selectivity. Intensified...

Artikel

Diglycerides of Natural Phenols and Organic Acids for Enhanced Biological Activities

von Jisu Hong et al.

· 14.08.2025

Diglycerides of natural organic acids and phenols were synthesized regio-selectively. Diglycerides are structurally similar to cell membranes and are expected to exhibit cell affinity and permeability. The flexible glycerol linkers allow the diglyce...

Artikel

Synthesis and Optical Properties of Near‐Ultraviolet‐Emissive B─O‐Containing Azaborines

von Peiyuan Yang et al.

· 14.08.2025

Dibenzo-1,4-azaborine (DBAB) derivatives containing boron–oxygen bonds were synthesized and their optical properties were investigated. In toluene, 2BO2Dpa exhibited ultrapure violet photoluminescence at 399 nm (FWHM, 17 nm). A 2BO2Dpa-based OLED ex...

Artikel

Theoretical Investigation on Cobalt‐Catalyzed C─H Borylation of Arenes Using a Terpyridine Ligand

von Jiawei Ma et al.

· 14.08.2025

Our study investigated Co-catalyzed C─H borylation of arenes using a terpyridine ligand from a theoretical standpoint. Through computation, we elucidated the overall mechanism including C─H activation, C─B formation, and catalyst regeneration. In ad...

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Alcohol Dehydrogenation Catalyzed by Azo‐Oxime Coordinated Ruthenium(II): A Strategic and Sustainable Route towards Site‐Selective C(sp3)–H Functionalization of 9H‐Fluorene

von Srijita Naskar et al.

· 14.08.2025

1. Robust and easy to prepare catalyst 2. Low catalyst loading 3. Short reaction time at relatively lower temperature. 4. Broad scope and high yield Abstract The bidentate redox non-innocent azo-oxime ligand p-chloro-aryl-azo-oxime (p-Cl-aaOH) ha...

Artikel

Tetrabenzo‐10‐Heterocorroles as π‐Extended Porphyrinoid Semiconductors: Synthesis, Properties, Structure, and OFET Performance

von Kento Teranishi et al.

· 14.08.2025

Tetrabenzo-10-heterocorrole metal complexes were successfully synthesized. These π-extended molecules exhibited narrow HOMO–LUMO energy gaps due to the effective π-delocalization incorporating the heteroatom. Single crystal X-ray diffraction reveale...

Artikel

One‐Pot Tandem Alkylsulfonylation/Cyclization of Unactivated Alkenes to Construct Alkylsulfonyl‐Containing Polycyclic Quinazolinones Under Photocatalysis

von Rong Huang et al.

· 14.08.2025

Visible-light photoredox-catalyzed one-pot tandem alkylsulfonylation/cyclization of unactivated alkenes to construct alkylsulfonyl-containing polycyclic quinazolinones has been accomplished. This mild transformation affords the desired products in h...

Artikel

Diastereoselective Michael Addition of Non‐Functionalized Furanone to Nitroalkenes in Aqueous Condition

von Kumar Naveen et al.

· 14.08.2025

We have developed a diastereoselective DMAP-catalyzed Michael addition of furanone (butenolide) to nitroalkenes. Notably, our method does not require the pre-activation of furanone as 2-(trimethylsiloxy)furan and utilizes water: ethanol as a solvent...

Artikel

Synthesis of Oligo(Triarylphosphine Sulfide)s for Stabilizing Pd Nanoparticles and Modulating Selective Semihydrogenation of Terminal Aryl Alkynes

von Hidetoshi Ohta et al.

· 14.08.2025

Pd nanoparticles, stabilized by a series of oligo(triarylphosphine sulfide)s, were prepared and evaluated as catalysts for the semihydrogenation of phenylacetylene. Stabilizing agents with a high number of coordination sites and a combination of p-p...

Artikel

Photo‐ and Electroluminescence of N,N‐Diphenylaminophenyl–Quinoxaline Donor–Acceptor‐Type Dyes: Electronic Impacts of Electron‐Withdrawing Ability of the Acceptor Unit

von Masaki Nagaoka et al.

· 14.08.2025

Compact N,N-diphenylaminophenyl–quinoxaline donor–acceptor-type dyes were synthesized, and the effects of substituents on the fluorescence properties were investigated. Introduction of electron-withdrawing groups to the quinoxaline acceptor caused a...

Artikel

Design and Synthesis of β‐Carboline Hydrazone Hybrids as New α‐Amylase and α‐Glucosidase Inhibitors: Inhibition Kinetics and Molecular Docking Studies

von Manal Al‐Sharafi et al.

· 14.08.2025

The current study has successfully designed and synthesized a series of β-carboline hydrazone hybrids as new α-amylase and α-glucosidase inhibitors. Inhibition kinetic analysis revealed that they are competitive-type inhibitors of α-amylase and non-...

Artikel

Base‐Metal‐Catalyzed Oxidative Cross‐Couplings Between 2‐Naphthols and Phenols or Arylamines

von Qi Liu et al.

· 14.08.2025

Unprecedented base-metal-catalyzed oxidative cross-couplings between 2-naphthols and phenols or arylamines have been described to produce 4-aryloxynaphthalene-1,2-diones and 4-(arylimino)naphthalen-1(4H)-ones in this report. With the present protoco...

Artikel

Tuning Antiaromaticity Through Meso‐Substituent Orientation in Core‐Modified Isophlorins

von Maika Isoda et al.

· 14.08.2025

The antiaromaticity of dithiadioxaisophlorins is controlled by the steric bulkiness of meso-substituents through their tilt angle relative to the macrocycle. Bulkier substituents maintain larger angles, preserving stronger antiaromaticity, while sma...

Artikel

Cascade C─H‐Alkenylation‐Intramolecular Aminative Cyclization of Benzylsulfonamides for Synthesis of Isoindoline Cores

von Arup Bairagi et al.

· 14.08.2025

One-step isoindoline synthesis from benzylamines with (SO₂(3-Npy)) as a directing group was achieved using Pd(OAc)₂ as a catalyst, Ag(I) as an additive, and Cu(II)-salt as an oxidant. Pd-assisted as well as alternative Pd-─Ag bimetallic catalytic pa...

Artikel

Sulfur‐Promoted, DABCO‐Catalyzed Reaction of β‐Nitrostyrenes with 4‐Hydroxycoumarins: Access to Furo[3,2‐c]chromen‐4‐ones

von Deepan Babu et al.

· 14.08.2025

A simple and elegant strategy for the synthesis of furo[3,2-c]coumarin derivatives has been developed via a one-pot, [3+2] annulation of β-nitroalkenes with 4-hydroxycoumarins. This reaction involves the formation of two new bonds—one C–C and one C...

Artikel

Donor–Acceptor Segregated π‐Conjugated Oligomers with Through‐Bond and Through‐Space Interactions

von Masayoshi Takase et al.

· 14.08.2025

Oligomerization of an orthogonally arranged donor–acceptor segregated molecule gave π-conjugated oligomers. The combined results of NMR, absorption, cyclic voltammetry, and DFT calculations supported the π-conjugation with both through-bond and thro...

Artikel

Organophotoredox‐Catalyzed CDC Reactions for the Synthesis of Diverse Heterocycles via C─N and C─O Bond Formation under Visible Light Irradiation

von Elavarasan Selvaraj et al.

· 14.08.2025

A metal-free, organophotoredox-catalyzed cross-dehydrogenative coupling reaction for synthesizing various biologically active heterocycles is reported. Diverse substrates were found to be amenable to this methodology, affording the corresponding cyc...

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Formal Dehydrative [3+2] Annulation of N‐Arylhydroxamine and Activated Alkyne Toward Indole

von Xiaoyan Hong et al.

· 14.08.2025

A cascade dehydrative [3+2] annulation reaction of N-substituted arylhydroxylamines and activated alkynes was developed for the synthesis of indole under catalyst-free conditions, water as the the only by-product during this transformation. Abstr...

Artikel

Phosphazene Base t‐Bu‐P2‐Catalyzed Substitution Reactions of para‐Hydroxybenzyl Alcohols

von Ozora Sasamoto et al.

· 14.08.2025

Substitution reactions of para-hydroxybenzyl alcohols are catalyzed by the phosphazene base t-Bu-P2. This system is compatible with substrates bearing various functionalities, including alkyl, methoxy, thiophenyl, halogen, and ester moieties. Mechan...

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Switchable Reaction of p‐Toluenesulfonyl Hydrazide With N‐Heteroaryl Ketones: Base‐Controlled Selective Synthesis of N‐Heteroaryl Alcohols and [1, 2, 3]‐Triazoloheteroarenes

von Yifei Wu et al.

· 14.08.2025

A switchable reaction of p-toluenesulfonyl hydrazide with N-heteroaryl ketones has been developed to synthesize N-heteroaryl alcohols and [1, 2, 3]-triazoloheteroarenes. p-Toluenesulfonyl hydrazide was found to be a reducing agent in the presence of...

Artikel

Exploration of Visible Light Assisted Anticancer Activity of Co(II) Flavonoids

von Namisha Das et al.

· 14.08.2025

Flavonoid-based Co(II) complexes exhibit significant photocytotoxicity in visible light with minimal dark toxicity in HeLa and A549 cancer cells by generating reactive oxygen species; inducing apoptosis and accumulating in the mitochondria. Abstr...

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Chlorine Radical Mediated Deprotection of Aryl Ethers via Photocatalyzed Ligand‐to‐Metal Charge Transfer

von Honghao Chen et al.

· 14.08.2025

A new strategy for photocatalytic deprotection of aryl ethers has been developed. In this work, Cl⁻ was converted to the key Cl• via the photocatalyzed LMCT pathway. After the cascade process of hydrogen atom abstraction and oxidation by O₂, ester i...

Artikel

Light‐Mediated Decomposition of Arylseleninic Acids in Aqueous Medium: A Green Alternative Toward Organoselenium‐Functionalized Imidazo[1,2‐a]pyridines

von Caroline S. et al.

· 14.08.2025

A new protocol to prepare 2-aryl-3-(arylselanyl)imidazo[1,2-a]pyridines under blue light irradiation, using benzeneseleninic acid derivatives as selenium source, is described. The experimental design approach (DoE) was used to establish the best rea...

Artikel

Regioselective Multicomponent Approach Promoted by p‐TSA: A Facile Synthetic Access to 3,5‐disubstituted 4‐pyridinone Frameworks

von Pooja Kumari et al.

· 14.08.2025

An efficient multicomponent cascade synthesis of 3,5-disubstituted 4-pyridinones involving C─O cleavage with concomitant C─C/C─N bond formation is reported. Abstract A facile multicomponent strategy for the regioselective synthesis of 3,5-disubst...

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Magic Blue‐Promoted Synthesis of a Highly Planar Tetraphenylbenzidine: Evaluation of Its Fundamental Properties and Unraveling the Intriguing Mechanism for Its Formation

von Kanata Wada et al.

· 14.08.2025

Magic Blue [MB, (p-BrC₆H₄)₃N^•+SbCl₆ ^–]-promoted oxidation of the triphenylamine-dyad mm-1 and subsequent reduction using triethylamine lead to formation of a novel tetraphenylbenzidine derivatives 4, which has a highly planar biphenyl moiety and...

Artikel

AIBN‐Mediated Radical Cascade Synthesis of Maleimide‐Fused Thiochromenes

von Jatin Sinhmar et al.

· 14.08.2025

Efficient synthesis of maleimides-fused thiochromenes via radical cascade reaction of aryl thiols with styryl diazo imides using AIBN as a radical initiator has been developed. Abstract A radical cascade reaction has been established for the effi...

Artikel

Dearomative Amination Cyclization of Tryptamines and Tryptophols via Enantioselective 1,6‐Addition of p‐Quinone Diimides (p‐QDIs)

von Parbat Subba et al.

· 14.08.2025

A chiral phosphoric acid catalyzed enantioselective aminative dearomatization cyclization of tryptamines and tryptophols, which enables the rapid access of 3-amino-pyrroloindoline and 3-amino-furoindoline derivatives with excellent enantioselectivit...

Artikel

Bis[1]benzothieno[1,4]thiazine‐S‐oxides–Luminescence of the Anti‐Anti‐Regioisomer

von Simone T. et al.

· 14.08.2025

Three regioisomeric bis[1]benzothieno[1,4]thiazine-S-oxides were synthesized by mild oxidation. Crystal structures reveal S-extra-oxide, N-intra conformers with paired-like substructures, and intermolecular distances as low as 3.30 Å. UV–vis absorpt...

Artikel

Thianthrene‐Based Thiapillar[6]Arene Derivatives: Design, Synthesis, and Characterization

von Masafumi Ueda et al.

· 14.08.2025

We developed a synthetic route to thianthrene-based thiapillar[6]arene derivatives (I-IV) via selective functionalization at the 2,8-positions of thianthrene and subsequent macrocyclization. The target macrocycles were prepared via Pd-catalyzed coup...

Artikel

Conformation‐Dependent Luminescence and Thermal Phase Transition of Crystals of a Tetrahydropentalene Derivative Bearing Aromatic Rings with Frustrated Free Rotation

von Tomoki Nagaoka et al.

· 14.08.2025

Tetrahydropentalene derivative BTP-An exists as two crystalline polymorphs, including the O-form and R-form. Due to their loose molecular packing, the polymorphs have different photoluminescence wavelengths and thermodynamic stabilities cont...

Artikel

Cyclotetrabenzil Oxime Derivatives

von Thusini P. et al.

· 14.08.2025

Cyclotetrabenzil octaketone has been elaborated into its octaoxime and octaoxime acetate derivatives. Their crystal structures reveal the arrangement of these macrocycles into nanotubes, albeit with quite different characteristics. Gas sorption data...

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Exploiting 3‐Methyleneisoindolinones as In Situ Generated Reactive Intermediates in the Synthesis of Tetrasubstituted Carbon Center

von Arben Beriša et al.

· 14.08.2025

A straightforward method for constructing a tetrasubstituted carbon center through the in situ formation of 3-methyleneisoindolinones as reactive intermediates has been developed. This process involves an acid-catalyzed Meyer-Schuster rearrangement ...

Artikel

Synthesis of 3,3‐disubstituted Tetrahydroisoquinolines (THIQs) via Base‐mediated [4 + 2] Annulation

von Jiaxu Feng et al.

· 14.08.2025

The [4+2] annulation for THIQs. Abstract In this research we represented a simple and elegant method for 3,3-disubstituted THIQs via base-mediated [4 + 2] annulation of α-amino acid ester derivatives and 1,2-bis(bromomethyl)benzene under mild co...

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Amino Acid Derived Hydrogen Bond Donor (HBD) Catalyst for the Synthesis of Cyclic Carbonates and Cyclic Dithiocarbonates: Experimental and Computational Studies

von Supratim Halder et al.

· 14.08.2025

In this research work, Amino acid derived functionalized compounds have been designed, synthesized, and utilized as Hydrogen Bond Donor (HBD) catalysts for the successful installation of CO₂ and CS₂ in epoxide for the synthesis of cyclic carbonates ...

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Mn(I)‐NNSe Pincer Complex Catalyzed Regioselective Synthesis of Bisindolylmethanes under Base and Solvent‐Free Conditions

von Suman Mahala et al.

· 14.08.2025

A synthesis of bisindolylmethanes catalyzed by an earth-abundant Mn(I)-NNSe pincer complex is presented, involving the reaction of indole with benzyl alcohol under solvent, additives, base, or hydrogen acceptor-free conditions. Abstract Here, we ...

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4,6‐O‐Phenylboronic Ester Protection for 1,2‐cis‐α‐Selective Glucosylation

von Yuta Umemura et al.

· 14.08.2025

The 4,6-O-phenylboronic ester protection for 1,2-cis-α-selective glucosylation, previously reported by the Crich group, was revisited and the stereodirecting effect of the cyclic protecting group was unveiled. 4,6-O-Phenylboronic ester-protected glu...

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Synthesis of 5‐Arylselenyluracils via Bromide‐Catalyzed Selective C(sp2)‐H Selenylation of Uracils

von Zhouting Zeng et al.

· 14.08.2025

This work describes the facile synthesis of 5-arylselenyluracils via bromide-catalyzed three-component reaction of Se powder, boronic acids, and uracils under metal-free and strong-oxidant-free conditions. Simple catalytic conditions, high efficienc...

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Investigation of Phosphine Ligand Effect on Tunable Optical Property of Novel Coumarin‐Triphenyliminophosphorane Fluorophores

von Heng‐Yan Lin et al.

· 30.08.2025

Novel coumarin-triphenyliminophosphorane (TPIPP) fluorophores with tunable optical properties are successfully synthesized via acid-promoted chromene-to-coumarin rearrangement strategy. The electronic effects of para-substituted phosphine ligands en...

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Synthesis of Diaryl Thiosulfonates via Electrochemical Cascade S─S‐Coupling Using Arylsulfonyl Chlorides/Arylsulfinate Salts

von Sushobhan Chowdhury et al.

· 30.08.2025

Single component does double duty! Arylsulfinate salts or arylsulfonyl chlorides alone act as the source of both the arylsulfonyl and arylsulfide fragments via electrochemical autocatalytic processes to generate diarylthiosulfonate. Wide substrate s...

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Synthesis of N‐Substituted 4‐Pyridones From Skipped Diynones via Intramolecular Base or Ag(I)‐Catalyzed Hydroamination

von Elisavet‐Maria Zantioti‐Chatzouda et al.

· 30.08.2025

A general protocol for the synthesis of N-substituted 4-pyridones from skipped diynones is presented via a base or Ag(I)-catalyzed hydroamination pathway. Abstract Cs₂CO₃ or CF₃COOAg catalyze the intramolecular 6-endo hydroamination of the Z-enam...

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Fluoranthene Embedded Doubly Fused Expanded Porphyrin

von Vratta Grover et al.

· 29.08.2025

The first example of a novel fluoranthene-embedded; doubly fused expanded porphyrin was synthesized via a [3 + 2] condensation of a newly synthesized fluoranthene-based tripyrrane with a readily available bithiophene diol in CH₂Cl₂; under mild acid-...

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Synthesis of Multisubstituted Pyranoindol‐1‐ones Using Iridium‐Catalyzed Intramolecular C─H Amination of 3‐Amino‐4‐phenyl‐2‐pyrones

von Ren Yamasaki et al.

· 29.08.2025

A method for the synthesis of multisubstituted pyranoindol-1-ones is developed, utilizing iridium-catalyzed intramolecular C─H amination of 3-amino-4-phenyl-2-pyrones synthesized via the conjugate addition of diethyl 2-aminomalonate to alkynyl keton...

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Halogen Bonding‐Mediated Glycosylation of 2,3‐Unsaturated Glycosyl Acetates via NCSCH2Cl/KI

von Xiaojun Li et al.

· 28.08.2025

The strategic application of non-covalent interactions has emerged as an innovative paradigm in carbohydrate chemistry. Herein, we described a thiocyanato-enhanced neutral monodentate halogen bonding donor demonstrating high efficacy in converting 2...

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A Straightforward Access to Enantiopure 4‐Hydroxy‐pipecolic Acid Peptidomimetics by aza‐Prins Cyclization/LiNTf2‐Promoted Aminolysis of Lactones

von Vianney Durel et al.

· 28.08.2025

Enantiopure constrained pseudodipeptides based on pipecolic acid scaffold are obtained by a two-step synthesis involving an aza-Prins cyclization to deliver piperidine-lactones, followed by LiNTf₂-promoted aminolysis with various amino acids. Abs...

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Advancing Sulfono Functionalization: Integrating Classic and Contemporary Approaches to Drive Innovation in Synthetic Chemistry

von Bhaskarjyoti Borah et al.

· 28.08.2025

The rising importance of sulfone-containing compounds in pharmaceuticals, agrochemicals, and materials science drives interest in innovative sulfono functionalization strategies. This review consolidates recent advancements, analyzes current methodo...

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Iodine‐Mediated Difunctionalization/Cyclization of N‐Alkenyl Sulfonamides to Access N‐Heterocyclic Derivatives

von Huilin Qiu et al.

· 28.08.2025

A variety of N-heterocyclic derivatives were synthesized by iodine-mediated aminative difunctionalization/cyclization of N-alkenyl sulfonamides involving nitrogen-centered radicals. Governed by the disulfide/diselenide reagent, the synthesis deliver...

Artikel

Advanced Pd–NAPA Precatalysts for Broad‐Scope Kumada–Tamao–Corriu Couplings of Challenging Aryl Chlorides

von Pei‐Zhen Xie et al.

· 26.08.2025

Effective Pd–NAPA precatalysts (NHC and phosphinous acid-based palladium precatalyst) enabled the KTC couplings of challenging aryl chlorides, sterically hindered reactants, and substrates with a functional-group tolerant pitfall. Pd(0)–PR₂(O^-) is p...

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The Structure‐Activity Relationship and Reusability of Chiral Azacrown Ethers Derived from L‐Threitol

von Bertalan Varga et al.

· 26.08.2025

Chiral azacrown ethers from threitol were synthesized, and their catalytic activity and reusability were investigated in liquid–liquid and solid–liquid phase-transfer reactions together with some previously synthesized catalysts. Some structure-effe...

Artikel

Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy

von Myungho Jung et al.

· 25.08.2025

Herein, we report a novel and efficient synthetic strategy for the construction of poly-substituted imidazo[1,2-a]pyridines from the reaction of enaminonitriles with propargylamines via a domino conjugate substitution–nucleophilic addition-cycloisom...

Artikel

Synthesis of Triaryl‐Substituted Acyclic Olefins via Palladium‐Catalyzed γ‐C(sp3)‐H Diarylation of 2‐(2‐Phenylpropyl)pyridine Derivatives

von Jin‐Ping Li et al.

· 25.08.2025

This study presents an efficient method for synthesizing triaryl-substituted acyclic olefins, employing palladium-catalyzed diarylation of primary C(sp³)-H bonds at the γ-position of 2-(2-phenylpropyl)pyridine derivatives, using halogen substituted ...

Artikel

Experimental and Theoretical Mechanistic Study on the 6‐Iodo‐2‐pyridone‐Catalyzed Aminolysis of Esters

von Takeshi Yamada et al.

· 25.08.2025

In the aminolysis of esters, acid–base bifunctional catalyst 6-iodo-2-pyridone exhibits high catalytic activity, particularly for phenyl esters. A π–π interaction between the catalyst and the phenyl ester is a key feature in the transition states. T...

Artikel

Terphenyl‐Derived Covalent Organic Polymer as Metal‐Free Catalyst for the Cycloaddition Reaction of Carbon Dioxide with Spiro‐Epoxy Oxindoles

von Shilpa Dabas et al.

· 25.08.2025

Terphenyl-derived covalent organic polymer for the cycloaddition reaction of carbon dioxide with spiro-epoxy oxindoles Abstract Covalent organic polymers are a class of fascinating material derived from pre-designed molecular scaffolds with tailo...

Artikel

10‐Azidotetrazolo[1,5‐a][1,10] Phenanthroline: A Case of Azido‐tetrazole Behavior in 1,10‐Phenanthroline with Unusual Molecular Structure

von Yong Qiang et al.

· 25.08.2025

10-Azidotetrazolo[1,5-a][1,10] phenanthroline: schematic diagram, disordered crystal structure, ESP plot of the optimized structures, fluorescence of the sample in acetonitrile under 365 nm UV light. Abstract In our quest for novel An/Ln separati...

Artikel

Design and Development of New Benzopyrazole Derivatives as Selective Inhibitors of Helicobacter pylori IMPDH

von Sachin Puri et al.

· 25.08.2025

Beznopyrazole based molecules are investigated as potential H. pylori IMPDH inhibitors. A total of 36 molecules having 3-carboxamido and 1-acetamido linker are designed and synthesized. Compounds SN-8.1 and SN-8.2 are the most potent HpIMPDH inhibit...

Artikel

Carbon–Carbon/Heteroatom‐Centered Diradical Mediated Synthesis of Valuable Cyclic Motifs by EnT Catalyzed HAT Cyclization

von Nirbhik Chatterjee

· 25.08.2025

In this Highlight, recent reports are presented featuring three unique catalysts—Ir-based, TXT, and Al-Salen—demonstrating how the EnT process can generate triplet diradicals to form attractive cyclic architectures via intramolecular cyclization. Ex...

Artikel

Benzo[d][1,3]Oxazine‐Assisted C─H Annulation of Arenes with Diarylacetylenes: Access to 3,4‐diarylisoquinolinones

von P. Naveen et al.

· 21.08.2025

A novel Rh(III)-catalyzed C─H annulation strategy has been devised to the synthesis of diarylisoquinolinones through a sequential C─H annulation of diarylethynes with 4H-benzo[d][1,3]oxazines. This is a direct method to generate highly functionalize...

Artikel

New Synthetic Pathway with Improvements and Optoelectronic Applications of 3,5‐Dihexyl‐dithienothiophene (DTT)

von Kun‐Hua Chiang et al.

· 21.08.2025

A new synthesis of dihexyl-DTT using inexpensive CuI and S₈ in the cyclization step is reported. DTT core-based π-extended oligoarenes are fabricated as effective hole-transporting materials (HTM) for inverted perovskite solar cells (iPSC). Abstr...

Artikel

Structurally Well‐Resolved Conformational Isomers in Expanded Porphyrinoids: Structures and Photophysical Properties

von Cun Yang et al.

· 21.08.2025

This review highlights recent advances in identifying and characterizing structurally well-resolved conformational isomers in expanded porphyrinoids. Molecular topological variations between these conformers often lead to distinct electronic propert...

Artikel

Palladium‐Catalyzed Formal [4 + 2] Benzannulation of 1‐ferrocenyl‐2‐bromobenzene with Alkynes

von Jiafeng He et al.

· 19.08.2025

A Pd-catalyzed formal [4 + 2] benzannulation of 1-ferrocenyl-2-bromobenzenes with diarylacetylenes has been developed, delivering various substituted naphtho-ferrocenes. Abstract A Pd-catalyzed formal [4 + 2] benzannulation of 1-ferrocenyl-2-brom...

Artikel

Design and Synthesis of Triazole‐Based Imidazolium Salts as Potent Integrin‐Linked Kinase (ILK) Inhibitors for Anti‐Metastatic Breast Cancer Therapy

von Alameer Ezat et al.

· 19.08.2025

In-silico molecular docking and in vitro cytotoxic evaluation of Compounds 6, 10, and 14 against MCF-7 cells. Structural representations, docking interactions, and microscopy images at varying concentrations (1000–31.25 µg/mL) are shown. IC₅₀ values...

Artikel

Visible‐Light‐Mediated Regioselective Trichloromethyl Hydroxylation of Alkenes: A Metal‐Free Strategy for β‐Trichloromethyl Alcohols

von Xian Jiang et al.

· 19.08.2025

A visible light-mediated strategy for the regioselective synthesis of β-trichloromethyl alcohols through a three-component reaction of alkenes with CCl₄ and TBHP under mild blue LED irradiation is disclosed.The protocol operates under ambient condit...

Artikel

Efficient Copper‐Catalyzed, One‐Pot Synthesis of N2‐Aryl Phosphoryl 1,2,3‐Triazole 1‐Oxides

von M. Mujahid et al.

· 19.08.2025

A facile one-pot, copper-catalyzed multicomponent protocol has been developed for synthesizing N²-aryl phosphoryl 1,2,3-triazole 1-oxide derivatives from readily available arylhydrazines, β-ketophosphonates, and tert-butyl nitrite, under mild reacti...

Artikel

Umpolung C(3)–H Functionalization of Indoles via I(III) Intermediates: Synthesis of Indol‐3‐yl Xanthates

von Nikolai A. et al.

· 19.08.2025

A semi-one-pot protocol for the synthesis of previously inaccessible, bench-stable O-alkyl-S-(indol-3-yl)-xanthates has been developed. The transformation involves in situ generation of DMIX(indol-3-yl)iodonium salts, followed by their reaction with...

Artikel

Regio‐ and Chemo‐Selective Hydration of Terminal Alkynes Catalyzed by Bis(dimethylglyoximato)cobalt(III) Complexes

von Ujala Maddheshiya et al.

· 14.08.2025

Chlorocobaloxime complexes featuring substituted pyridine as an axial ligand have been successfully employed as catalysts for the hydration of terminal alkynes to their corresponding methyl ketones in good to excellent yields under ambient reaction ...

Artikel

Versatility of Dialkyl Azodicarboxylates in Organic Transformations

von Anna V. et al.

· 14.08.2025

Dialkyl azodicarboxylates (DAAD) represent a significant class of organic compounds whose unique structure enables diverse applications in synthesis. Recognized for their role in the Mitsunobu reaction, these versatile reagents have evolved into too...

Artikel

Organocatalytic Synthesis of δ‐Sultone‐Fused Benzofurans and Indoles by Annulative SuFEx Reactions of β‐Arylethenesulfonyl Fluorides

von Qichao Zhang et al.

· 13.08.2025

Organic superbase BTMG catalyzed the annulative sulfur(VI)-fluoride exchange (SuFEx) reactions of β-arylethenesulfonyl fluorides with benzofuran-3(2H)-ones and oxindoles to afford δ-sultone-fused benzofurans and δ-sultone-fused indoles in good to ex...

Artikel

Tf2O‐Catalyzed Tandem Trifluoromethylselenolation/Cyclization of Alkenes for Synthesis of CF3Se‐Containing Heterocycles

von Sijie Zhu et al.

· 13.08.2025

We have developed a mild and practical tandem trifluoromethylselenolation/cyclization of alkenes using trifluoromethyl selenoxide and Tf₂O as a catalyst, affording CF₃Se-containing oxindoles and benzoxazines in acceptable yields. A mechanism involvi...

Artikel

The Synthesis of Nonsymmetric α‐hydroxy‐ethylidenebisphosphonic Derivatives by the Pudovik Reaction, Their Reactions, and Cytotoxic Activity

von Zsuzsanna Szalai et al.

· 13.08.2025

Nonsymmetric α-hydroxy-ethylidenebisphosphonates (HEBPs) are synthesized by the Pudovik reaction of dialkyl α-oxo-ethylphosphonates and P-reagents (such as dialkyl phosphites, alkyl phenyl-H-phosphinates or diarylphosphine oxides). In the presence o...

Artikel

Progress in Strain Promoted Azide‐Alkyne Cycloaddition (SPAAC) Reaction and Their Applications

von Ranjana Upadhyay et al.

· 09.08.2025

Strain-promoted azide-alkyne cycloaddition (SPAAC) offers a rapid, catalyst free bioorthogonal strategy to form stable triazole adducts. This powerful chemistry enables precise live-cell imaging, selective tumor cell labeling and targeted drug deli...

Artikel

Pull–Pull Halogenated β‐Cyanoacrylates in Aza‐Michael Reaction: Intriguing Problem of Regioselectivity

von Ilya A. et al.

· 09.08.2025

The regioselective addition of amines to halogenated cyanoenoates as the most interesting pull–pull alkenes bearing two acceptor functions that have close electronic and steric properties is studied. The fascination with these derivatives is explain...

Artikel

Data‐Driven Chemometric Modeling for Predicting the Performance of Sulfonated MXene Thin‐Film Nanocomposite Membranes in Desalination

von Lukka Thuyavan et al.

· 08.08.2025

A data-driven chemometric model was applied to sulfonated MXene-based TFN membranes to predict desalination performance. Using models like k-SVM-PSO, RF, and DT, the framework accurately predicted flux, salt rejection, fouling dynamics, and chlorina...

Artikel

I2/K2S2O8‐Catalyzed Cascade Synthesis of Insecticidal 2‐Imino‐1,3‐Thiazoles: A Sustainable Approach to Bioactive Heterocycles

von Bin‐Heng Nie et al.

· 08.08.2025

A highly efficient and widely applicable catalytic strategy for synthesizing 2-iminothiazoles, as well as their selenazole and oxazole analogues, was developed. This method utilizes a mild and sustainable cascade CH heterolization/CN amination react...

Artikel

Phenazines Synthesis by Palladium‐Catalyzed Reductive Cyclization of 2‐Nitro‐N‐Phenylanilines Using Gaseous CO or Its Surrogates

von Simone Galiè et al.

· 08.08.2025

A practical palladium (Pd)-catalyzed approach enables the synthesis of phenazines by reductive cyclization of 2-nitro-N-phenylanilines using either carbon monoxide (CO) gas or phenyl formate as an in situ CO source. The method avoids harsh reagents ...

Artikel

Deoxygenation of Alcohols in Organic Electrosynthesis: Basic Strategies and Recent Developments

von Zhenlei Zou et al.

· 06.08.2025

Alcohols, prevalent in organic molecules, drive vital deoxyfunctionalization applications across pharmaceutical and industrial fields. Traditional methods relying on stoichiometric oxidants/reductants generate by-products, causing inefficient proces...

Artikel

Electrochemically Catalyzed Direct Hydroxylation/Carbonylat‐ion of Benzyl C─H Bonds Using Water as Oxygen Source

von Hui Luo et al.

· 06.08.2025

This work employs electrocatalytic oxidation to directly functionalize benzyl C–H bonds, producing corresponding alcohols, aldehydes, and ketones. The method demonstrates broad substrate scope and excellent functional group tolerance, offering an ef...

Artikel

Nickel‐Catalyzed Hydrogenation and Dehydrogenation Processes: A Useful Tool in Organic Synthesis

von Rahul Paul et al.

· 31.07.2025

Graphical representation of nickel-catalyzed hydrogenation and dehydrogenation reactions using homogeneous, heterogeneous, and nanostructured catalysts. Abstract Catalytic hydrogenation and dehydrogenation are fundamental transformations in organ...

Artikel

N‐Formylation of Amino Acid Esters and Peptides via Peroxide–Mediated Decarboxylative Coupling with α‐Keto Acids

von Binduja Kadamannil et al.

· 31.07.2025

An environmentally benign approach for the synthesis of N-formyl amino acid derivatives and peptides via decarboxylative C─N coupling of alpha ketoacids, where carbon dioxide and water/tertiary butanol were formed as by-product. Here, f-Met, a pepti...

Artikel

Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core

von Reinier Lemos et al.

· 31.07.2025

An efficient method to develop novel dihydropyrido[3,2-e][1,3]selenazines iminium salts. A comparative study of the key reagent selenourea towards thiourea and urea was carried out to assess the contribution of chalcogen to the pathway. DFT (density...

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The Structure of Nitro‐ and Polynitropyrazoles: X‐Ray Crystallography Versus Theoretical Calculations

von Rosa M. et al.

· 31.07.2025

Abstract This publication presents the geometries of 157 nitro- and polynitropyrazoles. Among these, 109 compounds were theoretically studied using mainly the B3LYP/6–311++G(d,p) level of theory. Three-parameter Lee-Yang-Parr (B3LYP) is a density...

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Highly Regioselective Butylation of N‐Sulfonyl‐1,2,3‐triazoles by the Formation of Quaternary Carbon‐Centered C(sp3)─N Bonds

von Jian Ji et al.

· 30.07.2025

An efficient example of quaternary carbon-centered C(sp3)─N bond formation has been developed using N-sulfonyl-1,2,3-triazoles and tert-butyl hydroperoxide via a radical addition to triazoles followed by an aromatic desulfonation with high regiosele...

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Pd‐Catalyzed Highly Regioselective N‐Acylation of Indoles with Difluorocarbene as a Carbonyl Source

von Lu Wang et al.

· 30.07.2025

An efficient one-pot protocol for the exclusively N-regioselective synthesis of N-benzoylindoles has been developed, employing difluorocarbene: (CF₂) as a carbonyl-bridging moiety to simultaneously forge one C─C bond, one C─N bond, and one C═O bond....

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Phosphorylated Hydrazones and Diazophosphonate Synthesis Through Base‐Promoted Radical Reactions

von Qihao Jin et al.

· 30.07.2025

Herein, we report a regioselective phosphonylation of aldehyde-derived hydrazones via P-centered radical addition, expanding C─P bond formation to include dialkyl phosphites. Notably, 4-methylbenzenesulfonylhydrazones underwent an unexpected transfo...

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Non‐Noble Metal Catalysis in Focus: Unlocking Latest Emergent Frontiers in Amide Annulation Through C─H/C─X Activation

von Prakash K. et al.

· 29.07.2025

In this review non-noble metal catalyzed synthesis of bioactive chiral or achiral heterocycles have been accomplished by annulation of amides via C─H/C─X (X = F, Br, O, S, and C) activation assisted by diverse N-substituted amides as directing group...

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Self‐Assembly and Emission Properties of Benzo[e]pyrene Dicarboxylic Acid in Solution and Solid States

von Svetlana Em et al.

· 29.07.2025

A new pyrene derivative bearing a benzene dicarboxylic acid unit was designed for sensitive self-assembly in solid and solution states. Single-crystal X-ray analysis revealed polymorphism, with non-solvated and solvent incorporated forms showing dis...

Artikel

Synthesis and Physical Properties of Salphen‐Conjugated TTF‐Metal Complex [CuII(TTF‐Salphen)]2PF6

von Daiki Tauchi et al.

· 29.07.2025

A paramagnetic metal complex, [Cu(TTF-Salphen)], in which a tetrathiafulvalene (TTF) moiety is conjugated with a Salphen coordination site, was synthesized as a potential candidate for a new π-d system. Its radical salt, [Cu(TTF-Salphen)]₂PF₆, exhib...

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Photosulfonylation of Aryl Halides with Sodium Sulfinates Catalyzed by Heterogeneous Copper Polymers

von Lijie Chen et al.

· 28.07.2025

Heterogeneous HCPs-Cu were readily prepared by using direct knitting strategy, which enabled a general photocatalytic method for sulfonylation of aryl halides with sodium sulfinates. Besides the remarkably broad substrate scope (43 examples), and a ...

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Transition Metal Catalyst Free Expedient Catechol Oxidation to Quinone via Photocatalysis

von Souvik Barman

· 28.07.2025

The enzymatic substrate inhibition pattern was followed in the catalytic aerobic oxidation of 3,5-di-tert-butylcatechol (DTBC) in methanol utilising cyclic hindered base. The primary mechanistic finding for this aerobic oxidation was the reduction o...

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A Serendipitous Non‐Metal‐Mediated Sp3 C─H Functionalization of 2‐Methyl Indolyl Scaffold for the Synthesis of 2‐Alkenyl Indoles*

von Diksha Bansal et al.

· 28.07.2025

This work presents an innovative strategy for C─H functionalization of sp³ carbon, enabling the efficient synthesis of 2-alkenyl indole scaffolds, a bioactive olefins. This study broadens the scope of C─H functionalization by employing previously un...

Artikel

“On‐Water” Bisphosphorylation of β‐Trifluoromethyl Enones via Successive C(sp3)─F Bonds Functionalization: Synthesis of Multi‐Substituted Furans

von Peng‐Yuan Zhang et al.

· 28.07.2025

A transition metal-free method for the bisphosphorylation of β-trifluoromethyl enones with phosphine oxides in pure water was developed for the synthesis of densely functionalized furan derivatives. Abstract The selective functionalization of C(s...

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Electrochemical Catalysis of Coupling Reaction between Diselenide / Disulfide and Diazonium Salt

von Haoxiang Zhang et al.

· 28.07.2025

Herein, we report a sustainable electrochemical system for synthesizing organoselenium/sulfur compounds via coupling of diselenides/disulfides with diazonium salts. Simultaneously, this method can also be used to synthesize phenylselenides and alkyl...

Artikel

Recent Advances in Hetero and Homo Nazarov‐Like Cyclizations

von Nagam Satish

· 26.07.2025

The Nazarov cyclization is one of the most efficient synthetic approaches for the synthesis of five-membered carbocycles, utilizing the 4π-conrotatory electro-cyclization. However, in recent years, alternative methodologies that significantly enhanc...

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LiCl‐Promoted Branched Methoxycarbonylation of Propylene Using a Heterogenized Triphenylphosphine‐palladium Catalyst

von Xinyu Ma et al.

· 26.07.2025

This work reported LiCl-promoted branched selective methoxycarbonylation of propylene utilizing a heterogenized Pd/3V-PPh₃@POP catalyst. The presence of LiCl gave a 36.9% increased branched selectivity with a useful turnover number of 124.5 compared...

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Electron Donating Group Effect on C─C Bond Scission Ability of Indanedione Dimers in Their Solution and Solid State

von Yukina Yamamoto et al.

· 25.07.2025

Indanedione dimers bearing electron-donating thiophene groups show low-temperature C─C bond scission in solution via the captodative effect. This feature was significantly changed in the solid state, showing much higher bond scission temperature in ...

Artikel

Design and Asymmetric Synthesis of Unnatural Amino Acid Derivatives Showing Staircase and Orientational Chirality

von Anis Ur et al.

· 23.07.2025

Unnatural amino acid derivatives showcasing orientational and staircase chirality have been prepared by asymmetric synthesis and unambiguously confirmed by X-ray crystallography. Abstract Amino acids are basic building blocks of peptides and prot...

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Recent Advances in Transition Metal‐Catalyzed Synthesis of Bicyclo[4.1.0]heptenes from 1,6‐Enynes

von Perla Bharath et al.

· 23.07.2025

The transition metal-catalyzed synthesis of bicyclo[4.1.0]heptenes from 1,6-enynes has emerged as an efficient strategy for constructing strained carbo- and heterocycles. Recent advancements using gold, platinum, iridium, rhodium, and manganese cata...

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Amino Acids as Carboxyl Sources for the Palladium‐Catalyzed Remote Selective C(sp2)─H Acyloxylation

von Tao Zheng et al.

· 23.07.2025

We have developed a palladium-catalyzed remote selective C(sp ²)─H acyloxylation reaction using amino acids as carboxyl sources. This method efficiently delivers a series of amino acid-substituted aryl (alkenyl) ester derivatives in good to high yie...

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Recyclable Glucose‐Derived Carbon–Silica Supported Ni(0) Nanocatalyst for Suzuki–Miyaura Cross‐Couplings

von Dinesh Babu et al.

· 22.07.2025

A glucose-derived carbon–silica supported Ni(0) nanocatalyst was developed for Suzuki–Miyaura cross-coupling. Glucose serves as both reductant and carbon source, enabling additive-free Ni(0) formation. The catalyst exhibits high stability, no Ni ...