Efficient Copper‐Catalyzed, One‐Pot Synthesis of N2‐Aryl Phosphoryl 1,2,3‐Triazole 1‐Oxides

A facile one-pot, copper-catalyzed multicomponent protocol has been developed for synthesizing N²-aryl phosphoryl 1,2,3-triazole 1-oxide derivatives from readily available arylhydrazines, β-ketophosphonates, and tert-butyl nitrite, under mild reaction conditions. The method exhibits broad substrate scope, excellent functional group tolerance, and affords products in up to 92% isolated yield.

Abstract

A simple and facile one-pot process has been developed for the synthesis of N ²-aryl phosphoryl 1,2,3-triazole 1-oxide derivatives. This new approach utilizes simple and commercially available starting materials, operating under mild conditions. The method employs copper-catalyzed multicomponent reaction, involving the combination of arylhydrazines, β-ketophosphonates, and tert-butyl nitrite. The developed protocol shows excellent functional group tolerance permitting an extensive range of substrate scope up to 92% isolated yield.

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