Nickel(II) Chloride Catalyzed and Tetrahydroxydiboron Promoted Denitrative Difluoroalkylation of β‐Nitrovinylarene

A novel denitrative cross-coupling reaction between β-nitrostyrene and ethyl bromodifluoroacetate (or their derivatives) has been successfully achieved, utilizing nickel(II) chloride and tetrahydroxyboron as catalysts. The current method exhibits excellent regioselectivity and high efficiency, thus providing a novel strategy for the utilization of β-nitrostyrene.

Abstract

The difluoromethylene (CF₂) group is a highly valuable structural unit that significantly contributes to the research and development of novel pharmaceuticals. This work presents an effective synthesis of CF₂-containing compounds from β-nitrostyrene, facilitated by nickel chloride and tetrahydroxydiboron. The approach is simple, efficient, and highly selective, thus providing a novel strategy for the utilization of β-nitrostyrene.

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