Flavonoid-based Co(II) complexes exhibit significant photocytotoxicity in visible light with minimal dark toxicity in HeLa and A549 cancer cells by generating reactive oxygen species; inducing apoptosis and accumulating in the mitochondria.
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Switchable Reaction of p‐Toluenesulfonyl Hydrazide With N‐Heteroaryl Ketones: Base‐Controlled Selective Synthesis of N‐Heteroaryl Alcohols and [1, 2, 3]‐Triazoloheteroarenes
Asian Journal of Organic Chemistry, August 2025, DOI. Login für Volltextzugriff.
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A switchable reaction of p-toluenesulfonyl hydrazide with N-heteroaryl ketones has been developed to synthesize N-heteroaryl alcohols and [1, 2, 3]-triazoloheteroarenes. p-Toluenesulfonyl hydrazide was found to be a reducing agent in the presence of Et3N, whereas [1, 2, 3]-triazoloheteroarenes were obtained when NaOH was applied as a base.
Abstract
A novel switchable reaction of p-toluenesulfonyl hydrazide with N-heteroaryl ketones has been developed to synthesize N-heteroaryl alcohols and [1, 2, 3]-triazoloheteroarenes. p-Toluenesulfonyl hydrazide was found to be an efficient reducing agent for N-heteroaryl ketones in the presence of Et3N. A cascade cyclization reaction occurred when NaOH was applied as a base.
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