An efficient one-pot protocol for the exclusively N-regioselective synthesis of N-benzoylindoles has been developed, employing difluorocarbene: (CF2) as a carbonyl-bridging moiety to simultaneously forge one C─C bond, one...
Artikel
Highly Regioselective Butylation of N‐Sulfonyl‐1,2,3‐triazoles by the Formation of Quaternary Carbon‐Centered C(sp3)─N Bonds
Asian Journal of Organic Chemistry, August 2025, DOI. Login für Volltextzugriff.
Von Wiley-VCH zur Verfügung gestellt
An efficient example of quaternary carbon-centered C(sp3)─N bond formation has been developed using N-sulfonyl-1,2,3-triazoles and tert-butyl hydroperoxide via a radical addition to triazoles followed by an aromatic desulfonation with high regioselectivity in good yields without any additional catalysts or additives.
Abstract
An efficient example of quaternary carbon-centered C(sp3)─N bond formation has been developed using N-sulfonyl-1,2,3-triazoles and tert-butyl hydroperoxide with a high regioselectivity in good yields (71%–83%) without any additional catalysts or additives. The unprecedented reaction was possibly promoted by a radical addition to triazoles followed by an aromatic desulfonation process.
Zum VolltextÜberprüfung Ihres Anmeldestatus ...
Wenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.