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Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

Artikel

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

von Abdüllatif Karakaya et al.

· 11.08.2025

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy
GA: Oxidative stress plays a critical role in Alzheimer's disease (AD) by promoting Aβ plaque accumulation and tau pathology, accelerating neurodegeneration. Elevated reactive oxygen species contribute to cognitive decline through extensive oxidativ...
Neuroprotective Efficacy of Microwave‐Assisted Synthetized 2‐(5‐Cyclopropyl‐6‐Thioxo‐1,3,5‐Thiadiazinan‐3‐Yl) Acetic Acid in Mitigating Cognitive Deficits in Pentylenetetrazole‐Induced Mice Model

Artikel

Neuroprotective Efficacy of Microwave‐Assisted Synthetized 2‐(5‐Cyclopropyl‐6‐Thioxo‐1,3,5‐Thiadiazinan‐3‐Yl) Acetic Acid in Mitigating Cognitive Deficits in Pentylenetetrazole‐Induced Mice Model

von Tahir Iqbal et al.

· 18.06.2025

Neuroprotective Efficacy of Microwave‐Assisted Synthetized 2‐(5‐Cyclopropyl‐6‐Thioxo‐1,3,5‐Thiadiazinan‐3‐Yl) Acetic Acid in Mitigating Cognitive Deficits in Pentylenetetrazole‐Induced Mice Model
Microwave synthesis yielded 2-(5-cyclopropyl-6-thioxo-1,3,5-thiadiazinan-3-yl)acetic acid, confirmed by infrared, nuclear magnetic resonance, and electron ionization mass spectrometry. In a pentylenetetrazole-induced epilepsy model, it countered oxi...
High‐Performance Oxidation and Nanomolar Detection of Phenylhydrazine Using a 6‐Hydroxyflavone‐Based Molecular Electrocatalyst Functionalized Multiwalled Carbon Nanotube in Batch Injection Analysis

Artikel

High‐Performance Oxidation and Nanomolar Detection of Phenylhydrazine Using a 6‐Hydroxyflavone‐Based Molecular Electrocatalyst Functionalized Multiwalled Carbon Nanotube in Batch Injection Analysis

von Valisireddy Lavanya et al.

· 10.06.2025

High‐Performance Oxidation and Nanomolar Detection of Phenylhydrazine Using a 6‐Hydroxyflavone‐Based Molecular Electrocatalyst Functionalized Multiwalled Carbon Nanotube in Batch Injection Analysis
This study presents a novel, rapid method for in situ functionalization of carbon electrodes using redox-active form of the 6-hydroxyflavone. The resulting multiwalled carbon nanotubes with redox-active HFLA (MWCNT@HFLA-Redox) electrode enables sens...
Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2′‐Bipyridine‐4,4′‐Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition

Artikel

Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2′‐Bipyridine‐4,4′‐Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition

von Hussein Alchurak et al.

· 09.06.2025

Synthesis and Characterization of Co(II), Cu(II), and Ni(II) Complexes of 2,2′‐Bipyridine‐4,4′‐Dicarboxamide Ligands: Antibacterial Evaluation Against Resistant Bacteria and Enzyme Inhibition
Two new 2,2′-bipyridine-4,4′-dicarboxamide ligands and their Co(II), Cu(II), and Ni(II) complexes are synthesized and characterized. The L2-Co complex shows strong antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomon...