Exploring a Water–Ethyl Acetate System for the Efficient Synthesis of 4‐Aryl Quinolines

A sustainable and catalyst-free method for synthesizing 4-aryl quinolines is developed using a water–ethyl acetate solvent system under reflux conditions. This approach eliminates hazardous reagents while achieving high yields and purity. The protocol aligns with green chemistry principles, offering an efficient and environmentally friendly alternative for the synthesis of quinoline derivatives.

Heterocyclic compounds, particularly aryl quinolines, are of paramount importance in pharmaceuticals, materials science, and agrochemicals owing to their diverse biological and physicochemical properties. However, traditional synthesis methods often rely on organic solvents and catalysts, which raise environmental and health concerns while requiring high energy inputs. This study addresses these challenges by applying the principles of green chemistry to develop a sustainable, efficient, and environmentally friendly synthetic route for aryl quinolines.

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