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Zn‐Mediated Reductive Addition of Isocyanides with Unactivated Tertiary Alkyl Oxalates

Von Wiley-VCH zur Verfügung gestellt

A facile and efficient method was presented for the synthesis of 6-alkylated phenanthridine, which with hindered quaternary carbon centers via Zn-mediated reductive trapping of tertiary alkyl radicals with both electron-rich and electron-deficient aryl isocyanides using nickel as a promoter and operation friendly to easy to handle. Bench-stable and operation-friendly tertiary alkyl oxalates derived from abundant tertiary alkyl alcohols were first used as radical precursors for the alkylation of isocyanobiphenyl species. This reaction displays excellent functional group tolerance and broad substrate scope, allowing access to desired products in good to excellent yields.

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