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Cyclic Triimidazoles as Stabilizers for Gene Promoter and Human Telomeric DNA G‐Quadruplexes

Von Wiley-VCH zur Verfügung gestellt

New cyclic triimidazole derivatives with methylpiridinium or guanyl hydrazone moieties exhibit high stabilization potential and binding affinity to h-telo, c-myc, and c-kit2 G-quadruplexes


Abstract

The synthesis and characterization of a small series of cyclic triimidazole derivatives functionalized with methylated pyridine or guanidine moieties is reported. These compounds were tested for their ability to bind to G-quadruplexes from both telomeric and oncogene promoter sequences. Some of them exhibited high affinity and effective G-quadruplex-stabilizing properties. Overall, these compounds may represent useful leads for developing more potent and selective analogues.

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