Fachzeitschriften

Chemistry–Methods

Artikel

Direct Quantification of Ammonia and Alkylamines in Aqueous Environments Using Solid‐Phase Microextraction‐Gas chromatography‐Mass spectrometry

von Doha Zidouhia et al.

· 20.08.2025

Fast and Facile! The use of a solid-phase microextraction fiber allows direct sampling of aqueous solutions of ammonia for quantification using gas chromatography-mass spectrometry (GC-MS). The technique is insensitive to the presence of organic cos...

Artikel

Wettability‐Controlled Electrocatalytic Carbon Dioxide Reduction

von Lanze Li et al.

· 20.08.2025

Herein, the evolution of catalytic interface configurations in eCO₂RR is introduced, outlines the major challenges associated with constructing stable and efficient TPIs, and summarize recent advancements, such as hydrophobic polymer/molecular modif...

Artikel

Analytical Study of Lanolin as Potential Biomarker of Prehistoric Sheep‐Shearing Practice

von Claudia Adsuar et al.

· 20.08.2025

Lanolin, a complex wax found on sheep wool, accumulates on shearing tools, such as flint and obsidian blades, used since the Neolithic. This study explores lanolin's degradation patterns as a potential biomarker for prehistoric sheep-shearing practi...

Artikel

Upscaled Synthesis of α‐ and β‐Peptides in a Continuous‐Flow Reactor Using Propylene Carbonate as an Eco‐Friendly Solvent

von Nikolett Varró et al.

· 20.08.2025

A rapid and scalable continuous-flow solid-phase peptide synthesis technology, using eco-friendly propylene carbonate (PC) as a solvent is developed. Achieving high yields and purity, it synthesized α-peptides, β-peptide foldamers, and α/β-peptide c...

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Self‐Supporting Bamboo Charcoal with Outstanding Electromagnetic Interference Shielding Performance

von Yujun Li et al.

· 20.08.2025

In this work, the bamboo charcoal with a natural gradient structure is prepared via a one-step pyrolysis process, exhibiting excellent electromagnetic interference (EMI) shielding performance. The relationship between preparation conditions, microst...

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Initial Stages of Gas Diffusion Electrode Flow‐Cell CO2 Electrolysis—Monitoring via Synergetic Online Mass Spectrometry and Rapid Sample‐Trapping Gas Chromatography

von Christina Martens et al.

· 20.08.2025

This study introduces a synergistic mass-spectrometry and sample-trapping gas chromatography method to monitor product gas composition during dynamic CO₂ electrolyzer operation. It reveals how electrode–electrolyte interfaces influence the establish...

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High‐Throughput and Automated Anion Transport Assays

von Kylie Yang et al.

· 20.08.2025

Synthetic ion transporters show promise as therapeutics, but assessing their activity can be time-consuming, limiting the screening of large compound libraries. We developed an automated high-throughput assay that determines 24 EC ₅₀ values in one d...

Artikel

Real‐Time In Situ Raman Monitoring of Photomechanochemical Reactions

von Ivica Cvrtila et al.

· 20.08.2025

A proof-of-principle setup for real-time in situ monitoring photomechanochemical reactions is presented, using photoisomerization of azobenzenes, and photolysis of adamantane diazirine, as model reactions. With 4-methoxyazobenzene it is also shown t...

Artikel

Exploring Bonding in Bioinorganic Chemistry: Ab Initio Valence Bond Calculations of Iron(II)‐CO and Iron(IV)‐Oxo Units in Cytochrome P450 under Oriented External Electric Fields

von Enhua Zhang et al.

· 20.08.2025

Ab initio valence bond calculations under oriented electric fields along the bond axis of Fe(II)-CO and Fe(IV)-oxo units in cytochrome P450 enzymes highlight their effectiveness in probing complex bonding characteristics and ligand effects in bioino...

Artikel

Front Cover: Wettability‐Controlled Electrocatalytic Carbon Dioxide Reduction (Chem. Methods 8/2025)

von Lanze Li et al.

· 20.08.2025

The Front Cover depicts copper nanoparticles with finely tuned wettability beneath a cut-away electrolyte layer, forming abundant three-phase interfaces where CO₂, protons, and electrons meet. This balance of hydrophilicity and hydrophobicity enrich...

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Cover Feature: Upscaled Synthesis of α‐ and β‐Peptides in a Continuous‐Flow Reactor Using Propylene Carbonate as an Eco‐Friendly Solvent (Chem. Methods 8/2025)

von Nikolett Varró et al.

· 20.08.2025

A red squirrel with a nut symbolizes the importance of sustainability—a core value of a continuous-flow solid-phase peptide synthesis (CF-SPPS) approach. In their Research Article (DOI: 10.1002/cmtd.202500010), I. M. Mádity and co-workers reveal how...

Artikel

Frontiers of Synchrotron Methods for Actinide Science

von Damien Prieur et al.

· 20.08.2025

This article explores the application of synchrotron radiation techniques - XAS, XES, HERFD, RIXS, and XRD - to investigate actinide materials. It provides insights into electronic structures, oxidation states, and phase transitions, emphasizing the...

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Quantitative X‐Ray Fluorescence Imaging to Evaluate the Efficacy of Micro‐Structured Cellulose Foams and Poultices in Wall Painting Desalination

von Martina Romani et al.

· 30.08.2025

This work assesses, through a quantitative micro energy dispersive X-ray fluorescence imaging, the effective use of micro-structured cellulose foams as a sustainable alternative to traditional poultices for desalinating fresco paintings. Foams were ...

Artikel

Carbonylative Transformations of Aryl Sulfonium Salts

von Yan‐Hua Zhao et al.

· 28.08.2025

Carbonyl derivatives are widely present in biologically active molecules, pharmaceuticals, natural products, and materials, and their synthesis has garnered much attention. Direct carbonylation of aromatic CH bonds is an effective tool for the synt...

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4‐Methylbenzhydryl Bromine Resin: Bridging the Gap between 2‐Chlorotrityl Chloride and Wang‐Type Resins for the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

von Hassan Gamal et al.

· 28.08.2025

Methylbenzhydryl bromine resin give good performance in specific condition copared to wang and 2-chlorotrityl chloride resin. Over the last year, peptides have been consolidated as an important class of biomolecules, receiving increased attention f...

Artikel

Unique Mixed Valence Behavior of Tantalum and Electronic Structure of the Novel P1−xTa8+xN13(X = 0.1–0.15) Using Density Functional Theory and Soft X‐Ray Spectroscopy

von Claude Ceniza et al.

· 15.08.2025

An uncommon nitride featuring phosphorus surrounded by six nitrogen atoms reveals unexpected metallic behavior. Soft X-ray spectroscopy and density functional theory uncover mixed-valence tantalum and complex TaN bonding, unlocking new insights for...

Artikel

The Role of the Surface Energy of Tannin‐Based Adsorbent Materials on the Lead Removal Capacity in Contaminated Water

von Mª Ángeles et al.

· 04.08.2025

Sample with low concentration of surface groups presents low surface energy and in consequence low adsorption capacity independently of the specific surface area and micro and mesoporosity. In this work, inverse gas chromatography at infinite dilut...

Artikel

Optimizing Polyoxometalate Electrodes for Energy Storage via Cation Design and Thermal Activation

von Lucía Vizcaíno‐Anaya et al.

· 01.08.2025

The stability and electrochemical performance of Keggin-type polyoxometalate-based electrodes for energy storage are strongly influenced by the hydrophobicity of organic cations and enhanced through the thermal activation of the solid structures con...

Artikel

Making Cross Polarization Magic Angle Spinning Quantitative: A Solid‐State NMR/Multivariate Curve Resolution‐Alternating Least Squares Approach for Quantifying Crystalline and Amorphous Phases

von Chiara Sabena et al.

· 01.08.2025

A broadly applicable and robust solid-state NMR approach, combined with multivariate curve resolution-alternating least squares, is presented to overcome the limitations of traditional methods. By leveraging advanced spectral deconvolution, it ensur...

Artikel

Complex Material Analysis of Reverse Painting on Glass by Means of Photography, Microscopy, and Spectroscopic Techniques

von Markéta Dumpíková et al.

· 31.07.2025

The material research of reverse paintings on glass combines infrared spectroscopy and liquid chromatography–mass spectroscopy to investigate the binders. Observation methods (macro- and microphotography) and the scanning electron microscopy with en...

Artikel

Harnessing Synergies between Combinatorial Microfluidics and Machine Learning for Chemistry, Biology, and Fluidic Design

von Suyash S. et al.

· 30.07.2025

This review explores the synergy of combinatorial microfluidics and machine learning, highlighting their transformative impact on high-throughput experimentation, closed-loop reaction optimization, and autonomous platform development. Key applicatio...

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Plasma Diffuse Reflectance Infrared Fourier Transform Spectroscopy Cell Design and Experimental Set‐Up for Operando‐DRIFTS Investigations on Plasma‐Induced Heterogeneous Catalyzed Reactions

von Dilver Peña et al.

· 27.07.2025

A customized apparatus for operando plasma-diffuse reflectance infrared Fourier transform spectroscopy is developed by modifying the dome of a commercially available Harrick reaction chamber. The designed high-voltage electrode is mounted and attach...

Artikel

Can Conformers Be Identified via Cyclic Ion Mobility Mass Spectrometry? Hexosamine Epimers Reveal Ultrastable Ring Structures

von Viktória Goldschmidt et al.

· 23.07.2025

It was demonstrated how carbohydrate ring structures can be separated and identified using cyclic ion mobility mass spectrometry, making solid-, solution-, and gas-phase structures comparable. In addition, it was determined which collisional cross-s...

Artikel

Process Monitoring of Lactone Ring Formation and Opening by Operando Attenuated Total Reflectance Infrared Spectroscopy

von Jelle W. et al.

· 22.07.2025

Inline monitoring of chemical reactions using spectroscopy can lead to great improvements in process efficiency and economics. In this work, we performed inline attenuated total reflectance infrared spectroscopy on two reactions involving bioderived...

Artikel

eChem: Accelerated Method Development in Quantum Chemistry with Notebooks

von Manuel Hodecker et al.

· 10.07.2025

The benefits of using Jupyter Notebooks to simplify and accelerate scientific code development are demonstrated using the practical example of the analytical molecular Hessian. The eChem project has been previously presented as an interactive platf...

Artikel

Mechanochemical Synthesis of Pristine and Li‐Doped Zinc Orthostannate from Separate and Blended Binary Oxide Precursors

von Wojciech Marynowski et al.

· 08.07.2025

Mechanochemistry can be considered as the top-down and bottom-up synthetic methodology, but for the latter, there are some limitations, especially regarding particle size (nanometric species). It is presented that in specific precursors’ preparation...

Artikel

Few Steps, Big Impact: Recent Advances in the Streamlined Synthesis of Multiply Chiral Heterohelicenes with Tunable Optoelectronic Properties

von Mohamed S. et al.

· 02.07.2025

Heterohelicenes with multiple chiral axes have the potential to drive next-generation technologies due to their unique structural and optoelectronic features. This review highlights innovative short-step synthetic strategies for double and triple he...

Artikel

Terahertz Raman Optical Activity Reveals Emergent Supramolecular Chirality in Mononucleotide G‐quadruplexes

von Štěpán Jílek et al.

· 30.06.2025

Self-assembly of guanosine-5′-monophosphate into G-quadruplexes induces a cation-specific (sodium vs. potassium), intense terahertz Raman optical activity signal. The supramolecular helical arrangement gives rise to a distinct chiral vibrational sig...

Artikel

Sequential Ester Homologation–Nucleophile‐Guided Functionalization: A Chemoselective Access to Thioesters, Amides, and Acids

von Davide Castiglione et al.

· 27.06.2025

The homologation of esters—in the presence of a lithium carbenoid—to thioesters, amides, and carboxylic acid is reported. By controlling the tetrahedral intermediate collapsing and promoting a series of rearrangements ultimately leading to a high ...

Artikel

Design of a Gas Rapid Injection Nuclear Magnetic Resonance System for Structure Elucidations and Kinetic Analyses

von Lupita S. et al.

· 26.06.2025

A gas rapid injection nuclear magnetic resonance (GRI-NMR) device was designed and constructed for the precise delivery of gases at atmospheric pressures for real-time data acquisition. The GRI-NMR system precluded any modifications to the NMR instr...

Artikel

The [3,3]‐Sigmatropic Allyl Cyanate–Isocyanate Rearrangement on Levoglucosenone Derivatives Stereoselectively Provides 4‐Deoxy‐4‐Aminosugars

von Debora Pratesi et al.

· 25.06.2025

The Ichikawa rearrangement of allyl cyanates obtained in situ from levoglucosenone-derived allyl carbamates allows the synthesis of unique 4-deoxy-4-amino-d-allose derivatives with complete chirality transfer in a metal-free three-step, one-pot mann...

Artikel

A Tale of Two Designs: Comparing Design of Experiment Strategies for Reaction Optimization

von Linda Romano et al.

· 24.06.2025

The application of Design of Experiments (DoE) significantly accelerates the optimization of reaction conditions for previously unreported transformations. DoE achieves this by focusing experimental efforts, enabling efficient exploration of the s...

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Durable Etched Silicon Powder‐Supported Palladium Catalyst for Continuous Flow Hydrogenation and Reductive Alkylation

von Zhenzhong Zhang et al.

· 24.06.2025

Etched silicon powder-supported Pd is developed as a durable and efficient catalyst for continuous flow hydrogenation and reductive alkylation. This study develops a novel heterogeneous palladium catalyst immobilized on etched silicon powder, demon...

Artikel

A Scalable L‐α‐Glycerophosphorylcholine Synthesis through the Automatic pH‐Controlled (R)‐Glycidol Ring Opening with Phosphorylcholine

von Antonio Massa et al.

· 17.06.2025

Automatic titrator enables the regioselective ring opening of (R)-glycidol in water in the presence of phosphorylcholine, leading to the synthesis of L-α-glycerophosphorylcholine, a commercially available drug, in very high yield. The reaction is tr...

Artikel

Multilayered MXene/Pristine Carbon/Biomass Cellulose Film Electrode with Ultrahigh Volumetric Capacitance for Symmetric Flexible Supercapacitor

von Lina Liu et al.

· 06.06.2025

Multilayered sandwich-structured MXene/pristine carbon/biomass cellulose composite films have been constructed with a hierarchical network architecture. A symmetric flexible soft-pack supercapacitor fabricated by using the film retains 98% of its in...

Artikel

Compression‐Induced Amorphization of ZIF‐62 Leading to Formation of Porous Glass: Overcoming the Limitations of Current Methods

von Jaideep Mor et al.

· 02.06.2025

Nonhydrostatic compression in steps is applied to transform crystalline zeolitic imidazolate framework-62 into glass at room temperature. This method overcomes the limitations of existing approaches. This research reveals the mechanism of this phase...

Artikel

An Efficient Method Using Small‐Sized Datasets Based upon Generative Adversarial Networks: Investigation of Cluster Configuration Space

von Jintao Xie et al.

· 30.05.2025

An efficient method based on generative adversarial networks is proposed using small-sized datasets. The atomic and molecular cluster configuration spaces are investigated to show the generation ability of the proposed method. Benchmark results demo...

Artikel

iSELECTION: An Instrument to Study the Kinetics of Isomer‐Selected Gas‐Phase Ion‐Molecule Reactions

von Corentin Rossi et al.

· 16.05.2025

Isomer-specific reactivity is key in cluster chemistry. Herein, it is shown that how combining drift-tube ion mobility with mass spectrometry enables the derivation of reaction rate coefficients for coexisting C40+$\text{C}_{40}^{&amp;am...

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Low‐Micromolar Quantification of Fluorinated Analytes Using Hyperpolarized 19F Benchtop Nuclear Magnetic Resonance

von Ana I. et al.

· 12.05.2025

Limits of detection and quantification of fluorinated analytes by ¹⁹F benchtop (1 T) NMR spectroscopy in the high nanomolar to low micromolar range are achieved using signal amplification by reversible exchange (SABRE) combined with the multiplet-re...

Artikel

Magnetic Response of Paramagnetic Metal–Organic Frameworks Under an External Magnetic Field and Its Application for Sorption Quantification

von Rubén Pérez‐Aguirre et al.

· 12.05.2025

Strong external magnetic fields can keep paramagnetic porous particles static without falling down while immersed in a liquid medium, and the strength of the required magnetic field, controlled indirectly by the distance to a permanent magnet, corre...

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Capturing Electrochemically Galvanic Exchange Events between Silver and Gold in Nonequilibrium and Equilibrium Realms

von Bonito Aristide et al.

· 09.05.2025

A new methodology is presented to study the kinetics of the galvanic replacement reaction between silver and gold, allowing, for the first time to our knowledge, real-time monitoring of the dynamics of this redox reaction by quantifying the main dri...

Artikel

Determination of Diketopiperazine Formation During the Solid‐Phase Synthesis of C‐Terminal Acid Peptides

von Mani Kaushal et al.

· 02.05.2025

Diketopiperazine formation (DKP) is one of the most serious side reactions during peptide synthesis. An accurate method to determine the DKP formation in peptide synthesis on Wang resin is reported. Furthermore, the strategies to minimize this side ...

Artikel

Testing Protocols for Obtaining Reliable Pair Distribution Functions from Laboratory X‐Ray Sources Using PDFgetX3

von Till Schertenleib et al.

· 30.04.2025

This work explores data acquisition and reduction protocols for atomic pair distribution scheme that enhances high-angle data collection, and the effects of instrumental parameters on resulting pair distribution functions are examined. A correction ...

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Electron Transport Bilayer Design for Perovskite‐Based Tandem Solar Cells Using Thermal Evaporation

von Siwon Yun et al.

· 30.04.2025

We provide a comprehensive explanation of designing a bi-layer electron transport layer with a fullerene layer using the evaporation method in inverted perovskite solar cells (PSCs) and perovskite-based tandem solar cells (PTSCs). Furthermore, we pr...

Artikel

Polymer, Water, and Salt Partitioning in Complex Coacervates Characterized by Femtosecond Stimulated Raman Microscopy

von Francisco van et al.

· 30.04.2025

The partitioning of polymer, water, and salt within complex coacervates formed by the polyelectrolytes poly(diallyldiemthylammonium chloride) and poly(4-styrenesulfonate) is investigated using femtosecond stimulated Raman microscopy (FSRM). With FSR...

Artikel

Chemometrics‐Assisted Electrochemical Device for Cannabidiol Detection in Real Cannabis sativa Samples

von Wanda Cimmino et al.

· 30.04.2025

GA: Four-step process for cannabidiol (CBD) detection in Cannabis sativa extracts. (1) The plant extract is obtained. (2) An electrochemical sensor detects CBD using a screen-printed electrode. (3) Electrochemical signatures of real samples are reco...

Artikel

Harnessing Viral Proteases for Cellular and Molecular Engineering

von Mingguang Cui et al.

· 23.04.2025

Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation...

Artikel

Highly Sensitive, Low‐Cost Deep‐UV Resonant Raman Microspectroscopy Systems

von Joseph Harrington et al.

· 21.04.2025

Low-cost deep UV resonant Raman microscope for chemical sensing and imaging has been developed and its performance has been experimentally validated for several potential applications. Multimodal imaging capabilities of a new instrument have been de...

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Laboratory‐Based Time‐Resolved In Situ X‐Ray Absorption Spectroscopy for Tracking Transformations of Working Electrocatalysts

von Martina Rüscher et al.

· 08.04.2025

The experimental setup presented in this work combining laboratory-based X-ray absorption spectroscopy with an electrochemical reactor advances the fundamental understanding of electrocatalysts at extended time scales. By the example of the electroc...

Artikel

A Mechanochemical Route for the Synthesis of Diphenyleneiodonium Salts and the Estimation of Their Relative Solid‐State Reactivities

von Ipsha Shruti et al.

· 07.04.2025

An efficient mechanochemical route for diphenyleneiodonium (DPI) salt synthesis is reported which offers a sustainable and solvent-free alternative. The solid-state reactivities of the reported DPI salts were also assessed with the help of morpholog...

Artikel

Continuous Flow Block Copolymer Nanoaggregate Synthesis and Their Flow Dialysis Purification

von Gayathri Dev et al.

· 21.03.2025

This work details the methodology for the synthesis of block copolymer nanoparticles through continuous flow self-assembly and purification via flow dialysis. Nanoaggregates are formed by mixing block copolymer solutions in THF with water, followed ...

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Correlative Characterizations Reveal the Structure‐Bonding‐Property Relationship at a Local Scale

von Huaide Zhang et al.

· 02.03.2025

Grain boundaries (GBs) modify the local microstructures, chemical bonding, and carrier transport of polycrystalline materials, influencing their overall mechanical and functional properties. We developed a correlative characterization method by comb...