Cover Feature: Upscaled Synthesis of α‐ and β‐Peptides in a Continuous‐Flow Reactor Using Propylene Carbonate as an Eco‐Friendly Solvent (Chem. Methods 8/2025)

A red squirrel with a nut symbolizes the importance of sustainability—a core value of a continuous-flow solid-phase peptide synthesis (CF-SPPS) approach. In their Research Article (DOI: 10.1002/cmtd.202500010), I. M. Mádity and co-workers reveal how they used propylene carbonate (PC), a green solvent selected by using the GSK guide, to achieve high-yield synthesis of α- and β-peptides, including challenging sequences, even on >4 g scale. The image reflects low solvent use, reduced PMI, and the eco-friendly, scalable nature of this breakthrough CF-SPPS technology.

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