ChemSystemsChem

Crown ether active template synthesis (CEATS) is a recently developed method for accessing rotaxanes using kinetic control. This makes it possible to produce thermodynamically disfavored rotaxanes by coupling their assembly with simple chemical reac...

A cyclic reaction network providing high yields of products with high enantiopurity, maintained by the addition of fuel and elimination of waste, has been experimentally and theoretically analyzed and interpreted in the context of out-of-equilibrium...

The Front Cover illustrates the formation of a rotaxane by crown ether active template synthesis (CEATS). Depicted is the aminolysis of an activated ester, which produces a rotaxane containing an amide thread. Cover design by Anna Tanczos, Sci-Comm ...

Bottom-up fabrication of compartmentalized cell-like entities represents a promising avenue for reconstituting hierarchical cellular organization and emulating life-like behaviors. We review the recent progress in imitating cellular organization by ...

Molecular co-evolution on the early Earth. Here, we examine the effect of nucleotides on properties of model protocell systems. We demonstrate that building blocks of nucleic acids, and the lipid type, affect the resulting interactions. Most nucleos...

The Maxwell's Demon thought experiment creates nonequilibrium gradients, and underpins the molecular ratchet mechanisms that drive artificial motors and pumps. Lipid bilayers form membranes that closely mirror the compartments of Maxwell's Demon. Th...