Fachzeitschriften

Chemistry – A European Journal

Artikel

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

von Katharina Alker et al.

· 03.09.2025

Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top-down design of non-ionic detergents for the purification and analysis of intact membr...

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The Application of PEG‐functionalized Amphiphilic Pillararene in Drug Delivery Systems

von Long Yao et al.

· 03.09.2025

This review comprehensively summarizes the application of PEG-functionalized amphiphilic pillararenes in drug delivery systems for chemotherapy, phototherapy, and gas therapy of tumor. Some corresponding examples were discussed in detail to evaluate...

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Photoredox Mediated Synthesis of Substituted Imidazoles from Terminal Alkynes

von Jaswant Kumar et al.

· 03.09.2025

A visible light photoredox-induced approach for the synthesis of substituted imidazoles via alkynes, glycine methyl ester, and thiophenol is presented. The reaction is driven via photoinduced exploration of alkynes and their combination with thiol, ...

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Fluorescent Zr(IV) Metal‐Organic Frameworks for the Rapid and Sensitive Detection of Acidic Nitrophenols in Water

von Amina Haj‐Yahya et al.

· 03.09.2025

Three functionalized Zr(IV) MOFs detect nitrophenols in water by rapid and strong fluorescence quenching with detection limits below 0.040 µM, showing promise for real-time, in-field applications. Abstract Nitroaromatic compounds (NACs) are widel...

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Citrate‐Assisted Solvothermal Synthesis of SnO2 Porous Microflowers as Efficient Cathode for Advanced Hybrid Supercapacitor

von Chunwang Luo et al.

· 03.09.2025

SnO₂ porous microflowers were prepared by a citrate-mediated solvothermal route along with a post-annealing treatment in air. Such SnO₂ flowers exhibited a battery-type electrochemical response with a great specific capacity of 177.2 C g⁻¹ at 1 A g^−...

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The Ability of Enzymes to Preserve Reactive Conformations During Enzyme‐Catalyzed Reactions can be an Important Factor for Efficient Catalysis

von Mingling Yang et al.

· 03.09.2025

Enzymes may not only generate catalytic competent conformations for enzyme-substrate complexes but also be able to preserve the reactive conformations to the stage when the reactions reach TS to allow catalytic residues to exert their effects. Such ...

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Iron‐Sulfur‐Mediated C‐S Bond Formation: Mechanistic Insights from the state‐crossing tRNA Methylthiolation by the Radical SAM Enzyme MiaB

von Ze‐Han Ma et al.

· 03.09.2025

Iron-sulfur cluster chemistry: The mechanism of the MiaB-catalyzed methylthiolation of N⁶-isopentenyladenosine at position 37 in tRNA is elucidated. The reaction sequence clearly demonstrates that the state-crossing methylthiolation occurs following...

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Mild and Selective Trifluoromethylation of Peptides at Tryptophane Residues by a Water‐Soluble Copper Complex with Redox‐Active Ligands

von Marie‐Julie Tilly et al.

· 03.09.2025

Selective functionalization of aminoacids is a key endeavor in chemical biology. Radical manifolds offer interesting possibilities but can suffer from limited control over radical processes, resulting in a lack of selectivity in product distribution...

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Metallophthalocyanine‐based Conductive Frameworks as Working Electrode for Dehydrogenase‐Like Electrochemical Oxidation of Thioethers

von Pengjia Qi et al.

· 03.09.2025

The use of polymetallophthalocyanines as working electrode achieves dehydrogenase-like electrochemical oxidation of thioethers with excellent Faradaic efficiency over 96.3% and nearly 100% product distribution to sulfoxides, along with a high conver...

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A Mechanistic Insight into the Emission Behavior of Boron Difluorohydrazones (BODIHYs): Suppression of Kasha's Rule

von Rakshantha Srithar et al.

· 03.09.2025

Anti-Kasha property of phenanthrene-based BODIHY compounds leads to excitation wavelength-dependent RGB emissions. Experimental and theoretical studies reveal that both molecules emit from three different excited states, namely S₁, S₂, and S₃. Impor...

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Ion‐Pairing Assemblies of Polarized Charged Porphyrin

von Ryo Kitayama et al.

· 03.09.2025

The ion pairs, consisting of the polarized porphyrin Au^III complex as a dipolar π-electronic cation, formed crystal-state ion-pairing assemblies based on antiparallel stacking structures stabilized by dispersion forces along with reduced electrostat...

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Self‐Assembly of Heterochiral and Homochiral Peptides Conjugated to PNA Dimers and Their Integration in Peptide‐Based Hydrogels

von Ilaria Miglioli et al.

· 03.09.2025

Homochiral PNA-peptide conjugates mixed to homochiral peptides yield hydrogels supporting cell growth. Abstract Hybrid biomolecules composed of short peptides and nucleic acid analogues can self-assemble and are good candidates to produce new mat...

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Tuning Electrocatalytic Energy Release in Norbornadiene Based Molecular Solar Thermal Systems Through Substituent Effects

von Evanie Franz et al.

· 03.09.2025

We investigated how push–pull substituents influence the electrochemically driven energy release in norbornadiene-based MOST systems. Electron-donating groups proved to be decisive, with p-methoxyphenyl derivatives achieving up to 99% selectivity. T...

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Rational Design of Cationic Silyl Lewis Acids

von Corinna Girschik et al.

· 03.09.2025

The synthesis of a family of selanyl-stabilized silyl cations is reported. Variations of the scaffold, the substituents at the silicon and the selenium atoms allow to adjust their Lewis acidity over a wide range. The Lewis acidity is quantified by t...

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Reduction of Nitrite at a Copper(II) Trans‐κ1‐ONO Complex via Proton‐Coupled Electron Transfer and Oxygen Atom Transfer

von Donghyun Jeong et al.

· 02.09.2025

Herein, we describe the synthesis of a copper(II) nitrite complex which possesses unusual trans-κ ¹-O binding mode in trigonal bipyramidal geometry, and characterization through various physicochemical methods. The reduction of NO₂ ⁻ to release NO• ...

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Redox‐Assisted Controlled Radical Polymerization of Acrylates by Strategically Designed RuII‐FeII Heterobimetallic Conjugate

von Suman Dolai et al.

· 02.09.2025

Cooperativity wins: Judiciously designed heterobimetallic conjugates of Ru(II) and Fe(II) metal centers have shown remarkable redox cooperativity to achieve living and well-defined acrylate polymers. Abstract Employing heterobimetallic complexes ...

Artikel

Expanding Chemistry of Expanded Helicenes

von Shinji Toyota

· 02.09.2025

This review presents recent advances in the chemistry of expanded helicenes, defined as helicenes containing linearly fused benzene rings, as novel aromatic compounds. This review begins with a summary of their structural classification, followed by...

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Host Cavities Enhance the Photocatalytic Conversion of α‐Terpinene to Ascaridole Under Visible‐Light Irradiation

von Mawgan U. et al.

· 02.09.2025

BODIPY-functionalized host molecules are effective visible-light photosensitizers for the conversion of α-terpinene to ascaridole in the presence of molecular oxygen, providing up to a 28-fold increase in the rate of conversion depending on the host...

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An Unusual Activity of Conformationally Restricted Naphthalene Peri‐Dichalcogenides in the Reduction of Nitro and Azide Groups

von Debasish Giri et al.

· 01.09.2025

This work highlights the unique ability of a conformationally restricted dichalcogenide to reduce nitro and azide groups to their corresponding amines under physiological conditions. The redox potential is strongly influenced by the nature of chalco...

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New ESIPT‐Dyes of Record Capacity to Fluorescence Detection of H‐Bond Donor and Acceptor Molecules, Including Local Water Concentration

von Anton Hlavin et al.

· 01.09.2025

Multi-color fluorescent labels for detecting local water concentration at a selected cite of lipid-protein, protein-protein or protein-DNA complexes. Abstract 5-Substituted 3-hydroxychromones (3-HCs) are challenging to synthesize but are of signi...

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Electrochemical and Photoelectrochemical Transformations of Thioamides

von Zuzanna Bieńkowska et al.

· 30.08.2025

This work describes efficient EC and iPEC methods for the transformation of thioamides. The EC approach is inexpensive, mild, and metal- and catalyst-free. On the other hand, the interfacial iPEC method, due to the lower applied potential, proved to...

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A Bichromophoric Triazatruxene Tetrad as a Highly Tunable Multicolor Emitter and Its Application in OLEDs

von Lars Vogelsang et al.

· 30.08.2025

We report on a TAT tetrad, whose propargylic linkers electronically decouple the central TAT unit from the peripheral ones. This results in dual fluorescence and, at 77 K, dual phosphorescence emission. The emission color varies with excitation wave...

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A Strategic Advance from Pincer Complexes to Hexadentate‐Co(III) Catalyst for Metal–Ligand Cooperative Activation of Primary Alcohols to Access Highly Functionalized Pyrimidines

von Prashant Kukreti et al.

· 30.08.2025

Herein, we have developed a first cobalt(III) catalyst [Co(III)BPMAP-O]ClO₄ supported by a hexadentate ligand system with a metal-ligand cooperative approach for sustainable multicomponent reaction to access a library of highly substituted pyrimidin...

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Acidity Controlled Formal Nucleophilic Substitution of Hydrofluoroolefin‐based Iodonium Salt with O‐nucleophiles: Synthetic Application and Mechanistic Study

von János T. et al.

· 30.08.2025

A new method using hypervalent iodonium species derived from hydrofluoroolefin gas enables fast, mild, and efficient synthesis of fluoroalkyl ethers from phenols. Experimental and DFT mechanistic studies show that phenol acidity influences the react...

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The Important Role of the Polarization Effect in Cationic Hypervalent Chalcogen Bonds Catalysis

von Yanjiang Wang et al.

· 30.08.2025

DFT calculations demonstrate that increasing the central atom size (Se/Te) and incorporating stronger electron-withdrawing substituents (-CF₃, -F, -NO₂) in cationic hypervalent ChB catalysts amplify the σ-hole, thereby strengthening ChB interactions...

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Speciation and Luminescence of a Binuclear Lanthanide Complex Bearing an Aminophenolate Chromophore

von Villads R. et al.

· 29.08.2025

Lanthanide complexes are used in patients and for bioimaging and assays. The solution structure and speciation are critical when evaluating function, and here we fully unravel the structure and photophysics of a binuclear lanthanide complex. Abst...

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Systematic Mapping of Homoserine Lactone and Cyclodextrin Binding Strengths — Effects of Structural Features

von Otso I. et al.

· 28.08.2025

Binding of homoserine lactone (HSL) signaling molecules used by Gram-negative bacteria with native and substituted cyclodextrin (CD) host molecules was mapped. Between differently substituted HSLs with different alkyl chain lengths, chain length gov...

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Synthesis of Cyclobutenoates From Photochemical Rearrangement of α‐Diazo Cyclopropanes and Computational Studies

von Raphaël Dollet et al.

· 28.08.2025

The ring expansion of α-cyclopropyl diazoacetates into cyclobutenoates upon irradiation at 425 nm was reported in moderate to excellent yields (17% to 75%) and moderate to good regioisomeric ratio (55:45 to 82:18). The formation of two regioisomers ...

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Small Molecular Dibenzochalcogenophenes as Potent Organic Emitters

von Marco Schmiedtchen et al.

· 28.08.2025

This review compiles recent achievements and applications of purely organic small luminescent DBC. We present frequently employed functionalities and design strategies, accomplishing room temperature phosphorescence (RTP). In addition, we discuss th...

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Reusable Brønsted Acidic Ionic Liquid Catalyzed Reductive Alkylation of Quinolines to Functionalized Tetrahydroquinolines

von Siddhartha Kumar et al.

· 28.08.2025

Abstract A Brønsted acidic ionic liquid (BAIL)-catalyzed one-pot tandem reduction of quinoline to tetrahydroquinoline (THQ) followed by reductive alkylation by the aldehyde has been demonstrated under mild reaction conditions with a shorter react...

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Synthetic Membranes for Aqueous Organic Redox Flow Batteries (AORFBs): towards High Conductive and Selective Ion Channels

von Guang‐Hui He et al.

· 28.08.2025

Aqueous organic redox flow batteries (AORFBs) have emerged as a leading electrochemical technology for grid-scale energy storage, using water-based electrolytes to deliver inherent safety and cost efficiency. High-performance ion exchange membranes ...

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Asymmetric Synthesis and Biological Evaluation of 1,3‐ and 1,4‐Disubstituted Isoquinoline‐Containing Lipoxin A4 Analogues

von Denise Moran et al.

· 28.08.2025

(1R)- and (1S)-Epimers of novel isoquinoline-derived SPMs were prepared, with a Pd-catalyzed Heck reaction and a Ru(II)-catalyzed asymmetric transfer hydrogenation as the key synthetic steps. Biological assessment demonstrated that several analogues...

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Electron Density‐Dependent Mallory Photocyclization Constructs Rigid Saddle‐Shaped Polycyclic Aromatic Hydrocarbons with Enhanced Aromaticity

von Beibei Xiao et al.

· 28.08.2025

Saddle-Shaped Polycyclic Aromatic Hydrocarbons have been synthesized via highly efficient Mallory reaction, and exhibited extended aromatic skeleton with high quantum yields in solutions and aggregation casued quenching in solid states. Abstract ...

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Transformation of Silyl‐Protected Tetrafluorinated Thia[6]helicene S‐Oxide into a Difluorinated Coronene via Induced Desilylation

von Ayumu Nakao et al.

· 26.08.2025

Trimethylsilyl-protected tetrafluorinated thia[6]helicene S-oxide undergoes a more efficient transformation to difluorinated coronene than its unprotected S-oxide and S,S-dioxide counterparts. Si···F interactions and in-situ-generated sulfur monoxid...

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Layered MnAl Complex Oxide Realizes the Efficient Aerobic Oxidative Transformations of 1,2‐Diols and Alcohols Under Normal Pressure

von Anwei Wang et al.

· 26.08.2025

An efficient and convenient catalyst based on MnAl layered double oxide (Mn₂Al-LDO) has been developed for the aerobic oxidative transformations of 1,2-diols and alcohols under normal pressure without any additives. The excellent electron transfer a...

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Inherently Chiral Calix[4]Arene Derivatives: Concept and Enantioselective Synthesis

von Jia Feng et al.

· 26.08.2025

The past decade has seen a significant rise in the enantioselective synthesis of calix[4]arene derivatives with inherent chirality, which arises from the twisted macrocyclic structures of the linked aryl groups. This development is crucial for appli...

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Chemical Synthesis of the Mirror‐Image Fast‐PETase by the Enzyme‐Cleavable Solubilizing‐Tag Strategy

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Advances in the Hydroperoxidation of Propylene to Propylene Oxide (HOPO): from Nanoscale to Mesoscale and Macroscale

von Nidhi Kapil et al.

· 26.08.2025

This review highlights advancements in HOPO across nanoscale, mesoscale, and macroscale. It explores key aspects such as nanoparticle design, support materials, catalyst preparation methodologies, and reactor engineering. Additionally, the review hi...

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Pyrrole‐Imine Macrocycle: Self‐Organizing Cross‐Reactive Anion Receptor and Sensor

von Austin R. et al.

· 23.08.2025

An imine macrocycle comprising pyrroles as hydrogen-bond donors and an environmentally sensitive fluorophore displays a wide cross-reactive binding, which, in combination with an analyte-specific fluorescence response allows differentiation between ...

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Beyond Neuroprostanes: Total Synthesis and Epilipidomic Studies of a Novel Cyclopentenone Metabolite of Docosahexaenoic Acid

von Tereza Pavlíčková et al.

· 23.08.2025

Neuroprostanes are bioactive oxylipins from docosahexaenoic acid oxidation, serving as oxidative stress biomarkers. In this work, the enantioselective synthesis of 4-A₄-NeuroP-1,4-lactone and 4-deoxy-Δ^4,6-A₄-NeuroP has been accomplished using Michae...

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Synthesis and Evaluation of DNA Cross‐linkers by Click Chemistry‐Mediated Heterodimerization of Nor‐Tomaymycins

von Julia Friederich et al.

· 23.08.2025

Click chemistry promises a simple method to produce pyrrolo[2,1-c][1,4]benzodiazepine (PBD)-based DNA binders. DNA binding and covalent crosslinking capabilities have been validated for ‘clicked’ PBD heterodimers using thermal denaturation analysis,...

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Alternating Orthogonal Switching in a Thiophenyl‐Phenyl‐Bis‐Azobenzene Switch

von Dazhong Sun et al.

· 23.08.2025

This study employs computational calculations and ultrafast spectroscopy to design and probe alternate isomerization in a bis-azobenzene molecule. The phenyl- and thiophenylazobenzene moieties exhibit independent switching under different wavelength...

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Circular Dichroism and Multiphoton Circularly Polarized Luminescence Switching Using a Bis‐perylene Diimide Macrocycle

von Samuel E. et al.

· 23.08.2025

A chiral and configurationally stable bis-perylene diimide macrocycle is reported, which exhibits switchable circular dichroism (CD) and multiphoton circularly polarized luminescence (MP-CPL). This behavior is realized due to the macrocycle's tuneab...

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Zincophilic MOF Protective Layer for Stable Zinc Anodes in Zinc‐Ion Batteries

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Interfacial Co‐Operativity Enables Ultrafast Charge Transfer Within the Co‐Fe Prussian Blue Analogue|Zno Heterostructure

von Ratnadip De et al.

· 23.08.2025

This combined spectroscopic study shows that when the interfacial composition of PBA|ZnO heterostructure is engineered via a facile synthetic protocol the interfacial CT is promoted by a cooperative mechanism. In this mechanism, pre-existing oxidize...

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Steric and Geometric Tuning of π‐Conjugated Antennae in Europium(III) Complexes for Selective ADP Recognition

von Samantha E. et al.

· 23.08.2025

We present four new macrocyclic Eu(III) complexes and demonstrate how ligand structure and positional tuning of π-conjugated antennae modulate steric demand and anion binding site geometry. This enables size and shape complementarity for selective A...

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Direct Visualization of Plasmon‐ Induced Hole Injection in Electroactive Luminescent Monolayers on Gold Nanoparticles

von Baptiste Maillot et al.

· 23.08.2025

This work demonstrates the ability of plasmons to switch on the fluorescence of molecular monolayers through a hole injection process, in combination with an electrochemical reduction triggered at the tip and transferred to the monolayer by a redox ...

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Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity

von Andreas Gkanas et al.

· 22.08.2025

In the context of developing therapies for dementias and cognitive decline, potent dual acting molecules targeting the GPCR 5HT6 and the enzyme HDAC6 with favorable BBB penetration profile were designed and synthesised. Abstract Alzheimer's Disea...

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Ru(II)‐Based Photo‐Antibiotics: Light‐Driven Eradication of Bacterial Biofilm and Rapid Healing of Infective Wounds in Wistar Rat

von Arif Ali et al.

· 22.08.2025

This study presents the development of biocompatible Ru(II)-based photo-antibiotics that increase oxidative stress via ROS generation (both type I and type II pathways) and NADH oxidation, killing bacterial cells and eradicating bacterial biofilm wi...

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Substrate Epoxidation Catalyzed by the Nonheme Iron Dioxygenase Dapdiamide Biosynthesis Enzyme C. Why Is the Substrate Tethered?

von Jingyu Cao et al.

· 21.08.2025

In this work a computational study shows the differences in binding and catalysis of a nonheme iron oxygenase with tethered versus nontethered substrate. The tethered substrate is positioned in an ideal orientation near the active site, while the no...

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Nucleoside Reactions Shed Light on the Chemical Processes Underlying Interstrand Cross‐Link Formation at Apurinic/Apyrimidinic Sites in Duplex DNA

von Garam Shim et al.

· 21.08.2025

Abstract Apurinic/apyrimidinic (AP) sites in DNA can give rise to interstrand cross-links via reactions of the ring-opened AP-aldehyde residue with the exocyclic amino groups of 2′-deoxyadenosine, 2′-deoxyguanosine, and 2′-deoxycytosine residues ...

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Photocatalytic CO2 Reduction to Multi‐Carbon Products

von Ning‐Yu Huang et al.

· 21.08.2025

This review highlights recent progress in photocatalytic CO₂ reduction toward multi-carbon products, emphasizing key advances in catalyst design. Strategies including atomic site dispersion, co-catalyst integration, defect engineering, and utilizati...

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Fluorine‐Free Biomass‐Derived Ionic Liquid Electrolytes: Ion Dynamics and Electrochemical Properties

von Sayantika Bhakta et al.

· 20.08.2025

This study presents the synthesis, physical characterization, and transport as well as electrochemical properties of a novel class of ten ionic liquids (ILs). The ILs are created with two biomass derived anions such as furan-2-carboxylate [FuA] and ...

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Graphene Quantum Dots Drive Spontaneous Metal Reduction to Form Stable and Electroactive Core‐Shell Nanocolloids

von Josefina Ventre et al.

· 20.08.2025

This work demonstrates a spontaneous synthesis of metal (Au, Pt, and Ag) enveloped by crystalline graphene-quantum dots (GQDs). Aromatic and functional sp² and sp³ hybridized carbons, within the GQDs shell, play a crucial role upon the synthesis, el...

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NIR‐II Photothermal Conversion in Spin Crossover Metal‐organic Frameworks

von Guang Yang et al.

· 20.08.2025

The NIR-II photothermal conversion properties of SCO metal-organic frameworks (MOFs) are investigated for the first time, offering novel insights into the development of intelligent multifunctional materials. Abstract The synthesis of multifuncti...

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Xanthine Base Pairing with 2‐Aminoadenine and Canonical Bases in Purine Tracts of Watson‐Crick DNA: Impact of Purine‐, 7‐Deazapurine‐ and 8‐Aza‐7‐deazapurine Heterocyclic Skeletons on Duplex Stability

von Dasharath Kondhare et al.

· 20.08.2025

The impact of purine, 7-deazapurine and 8-aza-7-deazapurine heterocyclic skeletons on the stability of the xanthine-2-aminoadenine base pair is reported. In view of stability and pH dependence, the 7-deazaxanthine – 2-amino-8-aza-7-bromo-2′-deoxyade...

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Synthesis of Anthraquinone Mono‐ and Diboron Complexes with Near‐Infrared Panchromatic Absorption

von Yasuhiro Kubota et al.

· 19.08.2025

Anthraquinone boron complexes bearing β-iminoenolate ligand(s) exhibit strongly substituent-dependent absorption properties. Unsubstituted monoboron and diboron complexes show sharp UV–Vis–NIR absorption spectra resulting from increased molecular ri...

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Sono‐And Mechanochemistry‐Assisted Dual Strategies for Cyanomethylation of Carboxylic Acids: Robust and Practical Synthetic Protocols to a Diverse Series of Cyanomethyl Esters

von Pintu Karmakar et al.

· 19.08.2025

Showcasing sono- and mechanochemistry: A sonochemistry- and mechanochemistry-assisted dual-synthetic approach for biologically and synthetically promising cyanomethyl carboxylates as a rapid, high-yielding, and robust alternative synthetic protocol ...

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Solvent‐Induced Stabilization and Folding Pathways of α‐Helical Peptides: A Computational Investigation Using Steered Molecular Dynamics

von Takuya Uto et al.

· 19.08.2025

This study employed molecular simulations to investigate the stabilization of α-helical structures in HFIP compared to aqueous environments. SMD simulations demonstrated the stretching polypeptide chains to effectively preserve α-helical conformatio...

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Phytic Acid Assisted Preparation of Cu3P/Cu@C Composites as High Performance Anodes for Lithium Storage

von Jiaqi Liu et al.

· 19.08.2025

Polyaniline was polymerized and deposited on the surface of Cu nanowire@carbon (C) nanocore-shells, and utilizing phytic acid as phosphorus source, a unique Cu₃P/Cu@C composite spherical structure with with N,P-codoped graphitic carbon nanotubes ent...

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A 19F‐ATCUN Peptide NMR Probe for Selective Cu2+ or Ni2+ Sensing in Complex Biological Media

von Marie‐Julie Tilly et al.

· 19.08.2025

We report the design and synthesis of ratiometric ¹⁹F-ATCUN (Xxx-Zzz-His) peptide probes for the selective and reversible detection of Ni²⁺ and Cu²⁺ by ¹⁹F NMR spectroscopy. In contrast to fluorescence-based approaches, ¹⁹F NMR enables background-fr...

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Mechanochemical Preferential Bromination at the α‐Position of Activated Naphthalenes

von Pramod Kumar et al.

· 19.08.2025

This study focuses on the mechanochemical pathway for α-bromination of β-functionalized naphthalenes. This uses N-bromosuccinimide as a mild brominating precursor and highlights the tolerance and limitations of functional groups used. This applies o...

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Photoswitchable Merocyanine‐Amphiphiles with Programmable Self‐Assembly Times

von Man Him et al.

· 19.08.2025

A merocyanine-based amphiphile self-assembles in water to form visible-light-responsive ellipsoids that can be disassembled with visible light and reform abruptly ∼70 minutes after the light is switched off. The kinetics of the light-induced assembl...

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Cyanostilbenes as Selective Chloride Carriers Relying on CH‐anion Interactions

von Anurag Singh et al.

· 19.08.2025

This manuscript presents a series of eight small compounds based on the α-cyanostilbene motif and with different substituents. Three of these compounds show good rates of chloride transport, as well as selectivity for chloride over hydroxide, bicarb...

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Navigating Scholl‐Type Oxidative Coupling: An Electronic Programming Toward Path Revelation, Selectivity, and Control

von Sudhakar Maddala et al.

· 19.08.2025

Aryl substituents navigate the course of Scholl-type oxidative coupling in tetraarylthiophenes, enabling selective mono- versus dual cyclizations via electronic step discrimination and control. Guided by Hammett σ _p constants, this study deciphers r...

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Taming m‐Quionodimethanes by Dispersion Force: Cyclodimerization of (Trialkylsilyl)Ethynyl‐Substituted Indeno[2,1‐b]Fluorenes and Fluoreno[2,3‐b]Fluorenes

von Ching‐En Hung et al.

· 19.08.2025

Indeno[2.1-b]fluorenes and fluoreno[2,3-b]fluorenes having (trialkylsilyl)ethynyl groups dimerize spontaneously to yield the cyclodimers in the yields ranging from virtually zero to quantitative depending on the alkyl group. The regioselectivity of ...

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Coacervate Vesicles as Adaptive Platforms for Synthetic Biology and Smart Materials

von Francesco Vicentini et al.

· 19.08.2025

Coacervate vesicles are emerging protocells that merge coacervates’ functionality within membranised architectures. Their diverse formation mechanisms from coacervate droplets yield tunable, responsive systems with broad potential, from synthetic bi...

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Synthesis, Structure, and Reactivity of a 1‐Stannavinylidene‐NHC Complex: A Heavier Group‐14 Analogue of Vinylidene

von Teppei Asakawa et al.

· 18.08.2025

This paper describes the synthesis, structural characterization, and reactivity of the first stable 1-stannavinylidene-NHC complex, that is, a neutral monomeric compound with a C = Sn π-bond, which is a heavier group-14 analogue of vinylidene. The v...

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Aromatic Wall Extension of Glycoluril‐Derived Molecular Clips Enhances Binding of Planar Aromatic Dyes

von Collin J. et al.

· 18.08.2025

The influence of the length of the aromatic walls of methylene-bridged glycoluril-dimer-derived molecular clips on their binding affinity toward a panel of planar aromatic cations is reported. We find that anthracene-walled host H2 generally binds ≈...

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3′‐C‐Extended TNA: De Novo Synthesis, Enhanced Exonuclease Resistance, and Functional siRNA 3′‐Overhang Modifications Without Compromising Gene Silencing

von Yihang Gao et al.

· 18.08.2025

We designed and synthesized 3′-C-extended TNA analogs (ApioNA and BpioNA) through asymmetric aldol synthesis. These analogs, modified at the 3′-terminal of oligonucleotides, display significant exonuclease resistance, particularly BpioNA, which has ...

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In Situ Electrochemical Synthesis of Redox‐Active o‐Hydroquinone Metabolite of Flufenamic Acid on MWCNT Surface: Lifespan Extension in C. elegans via SOD Pathway

von Kondusamy Vignesh et al.

· 18.08.2025

This study presents an electrochemical strategy to generate the redox-active flufenamic acid-drug metabolite, FFA-Redox, which extends the lifespan of C. elegans worm-by up to 80% under pathogenic infection. The metabolite reduces intracellular ROS ...

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5d Orbital Covalency Controls the High‐Pressure Polymorphism of BaO

von Sophie Kogan et al.

· 18.08.2025

Barium oxide forms unique structures under pressure because of Ba—O bonding through the 5d orbitals. DFT bonding analysis shows that these bonds outweigh electrostatic interactions in BaO, but not CaO or SrO. Abstract The influence of metal d orb...

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Halogen Bond‐Tuning of Responsive Supramolecular Amino Acid Hydrogels

von Eleonora Veronese et al.

· 17.08.2025

XB strongly influences both solid-state packing and rheological properties of hydrogels of a tailored halogenated Fmoc-amino acid in biomimetic environments. Interestingly, the addition of effective XB-acceptors (Nu) to the gelation medium increased...