Study of Cytotoxic and Antibacterial Activity of Ag‐ and Mg‐Dual‐Doped ZnO Nanoparticles

A simple process for the fabrication of silver and magnesium dual doped Zinc oxide nanoparticles (Ag/Mg−ZnO NP) is described, which were studied for their anti-bacterial effect towards Streptococcus mutans bacteria, as well as for their cytotoxic activity on a breast cancer (MDA-MB-231) cell line. In light of the collected toxicity and antibacterial data as a compared between the doped and native nanoparticles, the applicability of Ag/Mg−ZnO NP in dental and medical sciences is proposed.

Abstract

A non-laborious process for the fabrication of silver and magnesium dual doped zinc oxide nanoparticles (Ag/Mg−ZnO NP) is described. The wurtzite ZnO nano-structures and the dual doped NP were analyzed by PXRD. SEM data showed the hexagonal morphology of our product, while the gathered anti-bacterial outcomes towards Streptococcus mutans bacteria through micro-dilution technic affirmed the enhanced performance of doped NP compared to the native ones. Furthermore, we gauged the toxic impacts of synthesized pure and Ag/Mg−ZnO NP against a breast cancer (MDA-MB-231) cell line through an MTT trial, which highlighted the superiority of the doped when compared to the native nanoparticles. In light of these comparisons, the applicability of Ag/Mg−ZnO NP in dental and medical science is proposed.

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