The study demonstrates Evans’ (R)-4-benzyl-2-oxazolidinone auxiliary enables efficient asymmetric synthesis of finerenone, achieving stereoselective naphthyridine core construction with 86:14 dr and 80% yield. Subsequent ammonia-mediated transami...
Artikel
Selective Synthesis of Furan‐3(2H)‐one Fused Seven‐, Eight‐, or Nine‐Membered Ring from the Reaction of Diynone and Cyclic β‐Keto Ester
European Journal of Organic Chemistry, September 2025, DOI. Login für Volltextzugriff.
Von Wiley-VCH zur Verfügung gestellt
A domino reaction of diynone and cyclic β-keto ester has been disclosed. This reaction provides a new strategy for the synthesis of a series of furan-3(2H)-one fused seven-, eight-, or nine-membered ring with good stereoselectivity and atom economy. Mechanistically, this reaction involves sequential Michael addition, intramolecular cyclization, ring opening, isomerization, anti-Michael addition and protonation.
A domino reaction of diynone and cyclic β-keto ester has been disclosed. This reaction provides a new strategy for the synthesis of a series of furan-3(2H)-one fused seven-, eight-, or nine-membered ring with good stereoselectivity and atom economy.
Zum VolltextÜberprüfung Ihres Anmeldestatus ...
Wenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.