Outside Front Cover: Conditional Stabilization of the Hypoxia‐Inducible Factor HIF1α: Photoswitchable Stapled Peptides Prevent Elongin BC–Mediated Degradation (Angew. Chem. Int. Ed. 36/2025)

The image illustrates the HIF1α-VHL signalling pathway as a set of interconnected gears. Our visible-light peptide, PSB-BCB-04, enables conditional stabilization of HIF-1α under normoxia by means of a tetra-ortho-fluoroazobenzene staple, whose cis conformation inhibits the VHL complex by disrupting the EloBC-pVHL interaction. Details of the study are reported by Olalla Vazquez et al. in their Communication (e202511183). Cover art image by M. Eugenio Vázquez (@glowsticks.bsky.social)

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