Gesellschaft Deutscher Chemiker

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Organocatalyzed Hydroacylation of Enones by Photosensitization of Acyl Silanes

Von Wiley-VCH zur Verfügung gestellt

A mild protocol for hydroacylation of enones through photosensitization of acyl silanes with thioxanthone under blue light (455 nm) irradiation is reported. A Brønsted acid is used as a co-catalyst in the reaction. The versatility of the method is demonstrated through inter- and intramolecular hydroacylation reaction. The hydroacylation product is applied for synthesizing an anti-HCV agent. Mechanistic insights are also provided through control experiments.

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