A density functional theory study of the ScIII-catalyzed asymmetric homologation of ketones with diazo compounds unveils a novel substrate coordination mode driven by the trans influence of counterions. This sheds light on the origins of the stereoselectivity and suggests a new strategy for adjusting it. More information can be found in the Research Article by M. Huang, Y.-D. Wu, and X. Zhang (DOI: <a href="https://doi.org/10.1002/chem.202303873">10.1002/chem.202303873</a>).

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Mechanistic Insights into Sc(III)‐Catalyzed Asymmetric Homologation of Ketones with Diazo Compounds: How Trans Influence Assists in Controlling Stereochemistry

A density functional theory study of the ScIII-catalyzed asymmetric homologation of ketones with diazo compounds unveils a novel substrate coordination mode driven by the trans influence of counterions. This sheds light on the origins of the stereoselectivity and suggests a new strategy for adjus...

Drug development strategy: Re and 99mTc tricarbonyl complexes with a pyridostatin moiety as a G4-binding motif have been obtained through a post-conjugation strategy using Pz-COOH-M. Metalation was found to enhance the complexes’ cytotoxicity in two cancer cell lines; the 99mTc congener was used to study binding and internalization. Possible uses of the complexes for DNA-interaction, cell and biodistribution studies are illustrated. More information can be found in the Research Article by E. Palma, A. Paulo and co-workers (DOI: <a href="https://doi.org/10.1002/chem.202400285">10.1002/chem.202400285</a>).

Artikel

Mechanistic Insights into Sc(III)‐Catalyzed Asymmetric Homologation of Ketones with Diazo Compounds: How Trans Influence Assists in Controlling Stereochemistry

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