Fluorinated Aminophosphonates and Aminophosphonic Acids: A Journey through Recent Advances

Recent advances in the synthesis of fluorinated aminophosphonates and aminophosphonic acids are highlighted, with particular emphasis on regio-, diastereo-, and enantioselective methods that allow precise introduction of fluorine atoms.

This review aims to summarize the most recent developments in the chemistry of fluorinated aminophosphonates and aminophosphonic acids, with a particular focus on literature published since the turn of 2016/2017. Fluorinated derivatives of aminophosphonates and aminophosphonic acids represent a rapidly growing area of interest due to their unique chemical properties and potential applications in various fields, including medicinal and agricultural chemistry. In this work, special emphasis is placed on highlighting the most significant reports concerning selective and efficient synthetic methodologies for these compounds. Particular attention is given to strategies that offer high yields, regio- or stereoselectivity, and operational simplicity, including direct fluorination, addition reactions, as well as catalytic and radical processes. Additionally, the review discusses the potential practical applications of these fluorinated derivatives, such as their roles as enzyme inhibitors, bioisosteres of amino acids, and potential pharmaceuticals.

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