Herein, we report an in-situ mild and metal-free protocol for thiomethylation of heteroarenes in high yields. The thiomethylation of various chloropurines, nucleosides, and chloroheteroarenes has been accomplished offering easy access to agrochemicals and synthetic molecules useful for drug discovery.

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Ambient Temperature Metal‐Free Thiomethylation of Chloroheteroarenes and Chloropurines

Herein, we report an in-situ mild and metal-free protocol for thiomethylation of heteroarenes in high yields. The thiomethylation of various chloropurines, nucleosides, and chloroheteroarenes has been accomplished offering easy access to agrochemicals and synthetic molecules useful for drug disco...

This study reported the synthesis of 6-methylphenanthridines from 2-isocyanobiaryls using dimethylformamide (DMF) as a methyl carbon souce. The reactions were conducted in open-air atmosphere using electrochemical process at ambient temperature.

 
<h2>Abstract</h2>
A benign electrochemical method to access 6-methylphenanthridines from 2-isocyanobiaryls using N,N-dimethylformamide (DMF) as a methyl source is reported. The protocol operates at ambient temperature without the need for harmful methylating reagents. Mechanistic studies suggested that DMF delivered a methylene synthon, followed by reduction at the cathode and tautomerization. The method offers environmental benefits by avoiding metal-based reagents and harsh conditions.

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Ambient Temperature Metal‐Free Thiomethylation of Chloroheteroarenes and Chloropurines

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Electro‐oxidative Methylation of 2‐Isocyanobiaryls Using N,N‐dimethylformamide (DMF) as Carbon Source: Synthesis of 6‐Methylphenanthridines

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