Scaling Amidation Reactions via Flow Mechanochemistry

By eliminating or drastically reducing the need for solvents, mechanochemical processes inherently minimize waste generation, simplify downstream purification, and align closely with the principles of green chemistry. Despite significant advances, the adoption of mechanochemistry in the fine chemical/pharmaceutical industry remains limited. Key barriers include challenges related to scalability, process robustness, economic viability, and compatibility with existing regulatory frameworks.

This webinar will focus on scaling mechanochemical processes to multikilogram scale, employing a variety of different reactor technologies such as reactive extrusion and continuous bead milling. Special emphasis will be placed on amide bond formation including peptide synthesis using a variety of different coupling reagents and conditions. Safety aspects will also be discussed.