Gesellschaft Deutscher Chemiker
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization

Vortrag (Online-Veranstaltung)

Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization

Dr. Magnus Nilsson

AstraZeneca

JAK-STAT cytokines are critical in regulating immunity. Persistent activation of JAK-STAT signaling pathways by cytokines drives chronic inflammatory diseases such as asthma. The presentation will cover the discovery of a highly JAK1-selective, ATP-competitive series of inhibitors having a 1000-fold selectivity over other JAK family members and the approach used to identify compounds suitable for inhaled administration. Ultimately, AZD4604 was selected as the clinical candidate.

Dienstag, 5. Dezember 2023

16:00 – 17:00
Registrierung

Dienstag, 5. Dezember 2023

16:00 – 17:00
Registrierung