Supramolecular assemblies of PBI-SAH have been developed which could detect chlorpyrifos in the nanomolar range and could also mimic AChE inhibitory activity of CPF to show promising aptitude as ‘safe insecticide’.
![Stereoselective Synthesis of Pyrrolo/Pyrido[2,1‐a]isoindoles via Alkyne Iminium Ion Cyclization of Vinylogous Carbamates](https://onlinelibrary.wiley.com/cms/asset/271e4459-4eb2-4f57-8e19-bedf31d8ea2e/asia202300626-toc-0001-m.png)
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Stereoselective Synthesis of Pyrrolo/Pyrido[2,1‐a]isoindoles via Alkyne Iminium Ion Cyclization of Vinylogous Carbamates
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A diastereoselective synthesis of pyrrolo/pyridoisoindole via alkyne iminium ion cyclization of vinylogous carbamate is described. This protocol features a broad substrate scope and easy scalability. An unusual 1,3-alkyl shift is observed with the substrates bearing a strong electron-donating group at the phenyl ring attached to alkyne.
Abstract
An efficient, acid-mediated, intramolecular alkyne iminium ion cyclization of oxoisoindolidene for the diastereoselective synthesis of pyrrolo/pyridoisoindole is described. This protocol features broad substrate scope and easy scalability. An unusual N to C-1,3-alkyl shift is observed with substrates bearing strong electron donating group at the phenyl ring attached to alkyne with concomitant hydration of alkyne to the ketone.
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