The SARS-CoV-2 virus that causes COVID-19 is a global health issue. The spread of the virus has resulted in more than six million deaths to date. The emergence of new viral strains highlights the importance of continuous surveillance of the SARS-C...
Small‐Molecule Modulation of Protein Lipidation: From Chemical Probes to Therapeutics
Von Wiley-VCH zur Verfügung gestellt
Protein lipidation is a widespread modification that regulates protein subcellular localization, structure and function. Dysregulation of protein lipidation has been implicated in various human diseases, including neurological disorders, infectious diseases and cancers. The lipid-modifying enzymes and their substrate proteins are emerging as attractive drug targets. The development of small-molecule modulators of protein lipidation has remarkably impacted our understanding of lipid-modification biology and potential therapeutics. In this review, we summarize the recent progress in the small-molecule targeting protein lipidation and highlight therapeutic opportunities.Zum Volltext
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