Silver catalysis exhibits a remarkable capacity for the activation of isocyanides. In recent years, silver-catalyzed and silver-promoted organic reactions of isocyanides have attracted much attention. They offered straightforward and facile acces...
Artikel
Selective Synthesis of Cyclic Nitroene‐Sulfonamides from Aliphatic Sulfamides and NOBF4
Von Wiley-VCH zur Verfügung gestellt
An efficient regio- and site-selective desaturation and β-nitration of cyclic aliphatic amides through a selective HAT/oxidative desaturation/electrophilic nitration process was realized.
Abstract
Described herein is the development of a desaturation and N-β-nitration reaction of cyclic amides, which is achieved by a selective hydrogen atom transfer (HAT)/oxidative desaturation/electrophilic nitration process. In this procedure, di-tert-butyl peroxide (DTBP) acted both as the oxidant and HAT reagent, and electrophilic NOBF4 as nitration source. Notably, the application of produced cyclic nitroene-sulfonamides was showcased by their efficient transformations into 3-piperidones and poly-substituted piperidine derivatives.
Zum VolltextÜberprüfung Ihres Anmeldestatus ...
Wenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.