Rh(III)‐Catalyzed Dual C─H Annulation of Isoquinolones and 1,6‐Diynes: Access to Naphtho‐Fused Polycyclic Derivatives

We disclose herein a Rh(III)-catalyzed weakly co-ordinating inherent functional group assisted dual C─H annulation of isoquinolones with 1,6-diynes, enabling the rapid construction of naptho-fused polycyclic derivatives.

Abstract

Transition metal-catalyzed annulations of unsaturated systems through dual C─H activation represent a straightforward tool to access multi cyclic scaffolds. We disclose herein, a Rh(III)-catalyzed weakly coordinating inherent functional group assisted dual C─H annulation of isoquinolones with 1,6-diynes. Some necessary control experiments were conducted to untangle the reaction mechanism.

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