![Diastereoselective Synthesis of Pyrazolo[1,2‐a][1,2,4]triazine Derivatives via Cross‐1,3‐dipolar Cyclizations of Azaoxyallyl Cations with N,N′‐Cyclic Azomethine Imines](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/d2fc3c3a-b1e4-467b-bb2f-ac505d3c3ec5/ejoc202300450-toc-0001-m.png)
Pyrazolo[1,2-a][1,2,4]triazine derivatives were synthesized in good yields and excellent diastereoselectivities.via cross-1,3-dipolar cyclizations of α-halohydroxamates (in situ generated azaoxyallyl cations) with N,N′-cyclic azomet...
Artikel
Rh‐Catalyzed Hydroheteroarylation of Styrenes: Access to Alkylated Heteroarenes with All‐Carbon Quaternary Centers
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In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position.
Abstract
Heteroarenes are common moieties in pharmaceuticals and naturally bioactive compounds. In this work, an efficient and atom-economic rhodium and thiophenol co-catalyzed hydroheteroarylation of styrenes with heteroarenes is reported. Alkylated unprotected heteroarenes are accessed under low catalyst loading. This protocol provides straightforward access to indoles bearing an all-carbon quaternary center at the C3-position.
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