A sustainable oxidation reaction of amines in water is established employing environmentally benign molecular iodine as the sole oxidant. It provides a facile access to imine and amide derivatives including bioactive molecules from readily...
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Recent Advances in Indole Synthesis and the Related Alkylation
Von Wiley-VCH zur Verfügung gestellt
The efficient synthesis of the indole blocks and related functionalizations, especially the alkylation of indoles are hot topics in recent years. This review will focus on the following two aspects: i) new developments for the synthesis of indoles which was catalyzed by transition metals, ii) the alkylation of indoles, including the one on N1 -position, C2 -position, as well as C3 -position.
Abstract
The derivatives of indoles are very useful intermediates in pharmaceuticals and organic synthesis. The efficient synthesis of the indole blocks and related functionalizations, especially the alkylation of indoles are hot topics in recent years. This review will focus on the following two aspects: i) new developments for the synthesis of indoles which was catalyzed by transition metals, the alkylation of indoles, including the one on N1 -position, C2 -position, as well as C3 -position. 1. Introduction 2. Synthesis of indoles catalyzed by various metals 2.1. Synthesis of indoles by palladium catalysts 2.2. Synthesis of indoles by other metal catalysts 3. Alkylation of indoles 3.1. N1 -alkylation of indoles 3.2. C2 -alkylation of indoles 3.3. C3 -alkylation of indoles
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