Tissue endothelial cells express ABC-transporter enzymes that change the concentration of small molecule within different tissue-compartments. These “blood-tissue barriers” have been shown to directly affect the efficacy and toxicity of anti-cance...
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Rational Design of a Highly Specific Prolyl Endopeptidase To Activate the Antihypertensive Effect of Peptides
Von Wiley-VCH zur Verfügung gestellt
Bioactive peptides produced by enzymatic hydrolysis of food-derived proteins could be used for various biomedical applications such as antihypertensive drugs. In the depicted study, a highly specific M. xanthus prolyl endopeptidase mutant was rationally designed by constraint/free molecular dynamics simulations and binding energy calculations towards the application in the hydrolysis of food-derived proteins to produce antihypertensive peptides with a proline C-terminus. More information can be found in the Research Article by J. Z. H. Zhang, L. Zhang, et al.
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