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Pd‐Catalysed Diastereoselective Synthesis of aza‐Spirocyclic P‐Stereogenic Phosphine Oxides

Von Wiley-VCH zur Verfügung gestellt

We designed a Pd-catalyzed cross-coupling reaction to synthesize diastereoselective spirocyclic amino-phosphine oxides with a P-stereogenic center. These potential P*(O), N-ligands contain both electronic donor and H donor/acceptor properties, which may be used to promote asymmetric catalytic reactions with high selectivity and efficiency.


Abstract

Phosphine oxides and spirocyclic compounds are privileged molecules widely employed in a variety of catalytic transformations either as chiral ligands for metals or bifunctional organocatalysts. Herein, we developed a Pd-catalysed cross-coupling reaction to synthesize spirocyclic amino-phosphine oxides with a P-stereogenic centre which could serve as potential P*(O), N-ligands or organocatalysis.

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