
<p>The direct α-alkenylation of nitrile was realized with palladium catalyst for the first time. Both cyano group and alkenyl group in the product can be functionalized, rendering this method a powerful protocol to synthesis a series of useful compounds.
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<h2>Abstract</h2>
<p>A direct α-alkenylation of nitrile compounds was realized with a palladium complex. This method exhibited excellent tolerance toward a variety of α-aryl alkyl nitriles and vinyl bromides, leading to the formation of a series of α-quaternary nitriles containing vinyl groups. Further manipulations of the obtained products were demonstrated, highlighting the potential synthetic utility of this method.</p>

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Palladium‐Catalyzed C−H Alkenylation of α‐Aryl Alkyl Nitriles

The direct α-alkenylation of nitrile was realized with palladium catalyst for the first time. Both cyano group and alkenyl group in the product can be functionalized, rendering this method a powerful protocol to synthesis a series of useful compounds. Abstract A direct α-alkenylation of nitrile...


<p>This review describes the overview of mechanistic and kinetics insights for guiding the design of catalysts for selective hydrogenation of functionalized nitroarenes to produce anilines, and summarizes the strategies developed for controlling the selectivity to target product, including isolating active sites, constructing synergistic active sites and regulating local environments of active sites.
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<h2>Abstract</h2>
<p>Selective hydrogenation of functionalized nitroarenes to anilines employed with heterogeneous catalysts is a significant process and widely applied in chemical industry. However, designing high-performance catalysts for these processes remains challenging. Recently, notable advancements have been achieved in synthesis methodologies, characterization techniques, and theoretical calculations, offering opportunities to gain insights into mechanisms. This review summarizes the recent progress in understanding the mechanistic aspects of selective hydrogenation catalysis for functionalized nitroarenes. We initiate by delving into the structure-performance relationship, with the aim of providing a comprehensive understanding of mechanistic and kinetic details in the selective hydrogenation of functionalized nitroarenes. Subsequently, we introduce various strategies for designing high-performance catalysts, categorizing them into three key aspects: isolating active sites, synergizing active sites and regulating local environments of active sites. Finally, we conclude with a concise overview of the current state of this field and provide a forward-looking perspective for future studies, emphasizing the high-performance design and manipulation of catalysts to achieve precise control over selectivity towards target products.</p>

Artikel

Palladium‐Catalyzed C−H Alkenylation of α‐Aryl Alkyl Nitriles

Abstract

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Mechanism and Kinetics Guided Design of Catalysts for Functionalized Nitroarenes Hydrogenation

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