Novel Strategy to Drive the Intracellular Uptake of Lipid Nanoparticles for Photodynamic Therapy

The superior efficacy of aminopolycarboxylic acid conjugated lipid nanoparticles in comparison to standard liposomal nanoparticles is described by Juan Chen, Gang Zheng et al. in their Research Article (DOI: 10.1002/anie.20218218). EDTA–lipid incorporated nanoparticles fluidize the cell membrane in a detergent-like manner and improve delivery to the cell by 25-fold. This novel nanoparticle design feature can be deployed across lipid nanoparticles to accelerate cancer nanomedicine drug delivery.

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