A fast colorimetric ascorbic acid sensing platform is constructed on the basis of powder porous carbon (PPC) fabricated by using corncob. The limit of detection of PPC with semi-graphitized structure and a large specific surface area of 57...
Nanoarchitectures to Deliver Nucleic Acid Drugs to Disease Sites
Von Wiley-VCH zur Verfügung gestellt
In order to selectively deliver nucleic acid drugs (antisense DNA, siRNA, DNAzyme, and others) to desired place at desired timing, various nanoarchitectures have been designed. There exist almost no limitations in the design of nanomedicines with respect to their size, shape, stability, and other features. These nanomedicines are highly promising for future applications.
Therapeutic nucleic acid drugs (antisense DNA, siRNA, DNAzyme, and others) have been widely employed to regulate the expression of a disease-causing gene. For the correction of a gene, the CRISPR/Cas9 system is available. Advantageously, they can be straightforwardly designed in terms of the Watson-Crick rule. In order to deliver these nucleic acid drugs to a target place in our body (organs and cells) at desired timing, various nanoarchitectures have been elegantly designed. Their primary roles are protection of drugs from degradation, increase of cell-membrane permeability, and spatiotemporal control of delivery. Encapsulated nucleic acid drugs are released by decomposing the nanostructures with either external stimuli or intracellular signals. Furthermore, therapeutic efficiency is enhanced by simultaneously delivering multiple types of nucleic acid drugs for their cooperation. Composites of nanoarchitectures and therapeutic nucleic acid drugs are highly promising for future applications.Zum Volltext
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