
<p>First published: 19 December 2022 Print ISBN:9783527350131| Online ISBN:9783527836208| DOI:10.1002/9783527836208 © 2023 Wiley-VCH GmbH
</p>
<br/>


Artikel

Inducing Targeted Protein Degradation: From Chemical Biology to Drug Discovery and Clinical Applications. Edited by Philipp Cromm


<p>Owing to tryptophan amino acid‘s unique photophysical properties, strong membrane-disrupting activity and low cytotoxicity, directed a straightforward lipidated version followed by facile synthesis of gold nanoparticles. These hybrid nanomaterials were proposed as potential antibacterial agents.
</p>
<br/>
<h2>Abstract</h2>
<p>Strategically controlling concentrations of lipid-conjugated L-tryptophan (vsPA) guides the self-assembly of nanostructures, transitioning from nanorods to fibres and culminating in spherical shapes. The resulting Peptide-Au hybrids, exhibiting size-controlled 1D, 2D, and 3D nanostructures, show potential in antibacterial applications. Their high biocompatibility, favourable surface area-to-volume ratio, and plasmonic properties contribute to their effectiveness against clinically relevant bacteria. This controlled approach not only yields diverse nanostructures but also holds promise for applications in antibacterial therapeutics.</p>

Artikel

Inducing Targeted Protein Degradation: From Chemical Biology to Drug Discovery and Clinical Applications. Edited by Philipp Cromm

Jetzt nächsten Artikel lesen:

Antimicrobial peptide mimetic minimalistic approach leads to very short peptide amphiphiles‐gold nanostructures for potent antibacterial activity

Überprüfung Ihres Anmeldestatus ...