Two new metal-free photocatalytic cyclopropanations employing eosin in the green solvent ethanol have been developed and then applied to the synthesis of colibactin warhead models. Using the models, we show what features can lead to nucleo...
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Hydrofluorination of Alkynes: From (E) to (Z)
Von Wiley-VCH zur Verfügung gestellt
The hydrofluorination of alkynes provides direct access to synthetically useful monofluoroalkenes and difluoroalkanes. This review showcases the developments on this subject, from early work to recent advances on various substrates.
Abstract
The hydrofluorination of alkynes is an efficient synthetic route to monofluoroalkenes or difluoroalkanes. Both fluorinated motifs have found applications in medicinal chemistry and beyond. This review explores the recent advances in the hydrofluorination of diverse alkynes through various activation methods, from classical coinage metal catalysis to metal-free conditions. The range of alkynes goes from the simplest unactivated alkynes to activated ones (ynones and derivatives, ynamides, alkynyl sulfides and sulfones as much as haloalkynes). Regio- and stereoselective methods exists, but there is still room for improvement depending on the type of alkyne.
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