The photophysics of a helicene derivative in which two benzene units are replaced by thiophene units (thiohelicene, 6H) was studied by steady state and transient absorption and emission spectroscopies covering time ranges from femtoseconds to minu...
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Hydrodifluoromethylation of unactivated alkenes enabled by Visible‐Light Photocatalysis
ChemPhotoChem, März 2024, DOI. Login für Volltextzugriff.
Von Wiley-VCH zur Verfügung gestellt
Photocatalytic hydro-difluoromethylaton of unactivated alkenes has been developed using a commercially available difluoromethylating reagent (CF2HSO2Na). This methodology tolerates a variety of functional groups and allows late-stage modification of various alkenes derived from pharmaceutically relevant drugs.
Abstract
In the present manuscript, we have reported a general catalytic strategy that allows the synthesis of a variety of difluoro methylated alkanes from the corresponding unactivated alkenes using commercially available radical difluoromethylating reagent (CF2HSO2Na) under visible light photocatalysis. Further, this strategy allows the late-stage modification of various alkenes derived from pharmaceutically relevant drugs.
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