In this work, two rhodamine-anthracene derivatives (RA1 and RA2) were synthesized by incorporating diamine chains of varying lengths between the rhodamine and anthracene moieties. RA1 and RA2 exhibited improved selectivity for Hg2+ and Fe3+ ions, respectively. These findings suggest that the selectivity of the probes can be controlled by altering the length of the intramolecular flexible chain.
Two rhodamine-anthracene derivative probes (RA1 and RA2) were designed and synthesized to incorporate different lengths of diamine chains between the rhodamine and anthracene moieties. Among the 16 different metal ions tested, RA1 exhibited the highest fluorescence enhancement in response to Hg2+ with a limit of detection (LOD) of 3.76×10−7 M, while RA2 showed the greatest fluorescence enhancement in the presence of Fe3+ with the LOD of 2.41×10−7 M. Notably, RA1 effectively eliminated the interference caused by Fe3+ during Hg2+ detection, whereas RA2 successfully eliminated the interference of Hg2+ during Fe3+ determination. This response difference between the two ions holds particular importance in scenarios where both heavy metal ions coexist. Additionally, fluorescence microscopy imaging of mouse mammary cancer cells (4T1) under the influence of Fe3+ demonstrated the potential applications of the probe. This study highlights the significance of a simple molecular design approach in tailoring probe selectivity by modifying the intramolecular flexible chain length.Zum Volltext