Six new cytotoxic aplaminone derivatives 3–8 were discovered from the herbivorous marine mollusk Aplysia kurodai. A comprehensive LC–MS/MS analysis of the extracts of sea algae distributing in the habitats of A. kurodai
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Hemin‐Promoted Direct C−H Thiolation in the Synthesis of Diaryl Sulfides
Von Wiley-VCH zur Verfügung gestellt
A new method for direct preparation of diphenyl sulfides using P-toluenesulfonyl chloride as an effective thiophenyl radical precursor with assistance from Hemin. Various substituted anisoles and benzenesulfonyl chlorides are well tolerated. Gram scale reactions showed a satisfactory performance, demonstrating the potential synthetic application of this method.
Abstract
Diaryl sulfides are a class of important synthetic chemical units. Herein, we report a new method for direct preparation of diphenyl sulfides using P-toluenesulfonyl chloride as an effective thiophenyl radical precursor with assistance from Hemin. Various substituted anisoles and benzenesulfonyl chlorides are well tolerated, resulting in moderate to good yields of diaryl sulfides. The potential of the proposed method is validated by good yields obtained in gram scale reactions.
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