Bioconjugation of chemical entities to biologically active proteins has increased our insight in the inner workings of a cell and resulted in novel therapeutic agents. A current challenge is the efficient generation of homogeneous conjugates of na...
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Exploring the Effects of Mutagenesis on FusionRed by Using Excited‐State QM/MM Dynamics and Classical Force Field Simulations
Von Wiley-VCH zur Verfügung gestellt
Three computationally tested variants of the FusionRed protein are on display in glass cloche bells. All three platforms are colored by the excitation wavelength of FusionRed, while each protein structure is colored by the emission wavelengths. Additionally, the experimentally demonstrated increased fluorescence of C158I is represented by the brighter light emission strength of the structure, and our predicted return of the A157N/C158I variant to a WT-like behavior is shown by the reduced brightness. More information can be found in the Research Article by A. R. Walker et al.
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