Eutectic Mixture of Fenofibric Acid and Syringic Acid: Improvement of Dissolution Rate and Its Antihyperlipidemic Activity

Fenofibric acid‘s poor aqueous solubility was improved by preparing a eutectic mixture with syringic acid using the solvent co-evaporation method. The solid-state properties of the mixtures were characterized, and their solubility and dissolution rates were studied. The study showed enhanced solubility and dissolution rates. In vivo antihyperlipidemic activity evaluation showed enhanced effectiveness compared with fenofibric acid alone.

Abstract

Fenofibric acid is a poorly water-soluble drug with high permeability; thus, it is classified as a Biopharmaceutical Classification System (BCS) class II. This study aimed to prepare a eutectic mixture of fenofibric acid with syringic acid as a coformer to improve its solubility, dissolution rate, and antihyperlipidemic activity. The solvent co-evaporation method was used to form a eutectic mixture. Solid-state properties were characterized, solubility and in vitro dissolution profiles were studied, and in vivo antihyperlipidemic effectiveness was investigated in male Wistar rats. The results showed that the eutectic mixture of fenofibric acid-syringic acid enhanced the solubility (3.4-fold) and in vitro dissolution rate (3.62-fold) and significantly improved the antihyperlipidemic activity compared with intact fenofibric acid.

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