A novel strategy for synthesizing structurally diverse 2-pyrrolidinons by a NHC-catalyzed tandem radical cyclization process has been developed. This reaction proceeds through a radical coupling approach, which not only shows broad substra...
Artikel
Efficient Amide Formation from Non‐Activated Cyclopropyl Ester via Acyl Fluoride Generation Using Hypervalent Iodine(III) Reagent and Selectfluor
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A novel and unique activation method for esters possessing a non-activated cyclopropyl moiety as a potential activating group is developed for acyl fluoride generation using a hypervalent iodine(III) reagent and Selectfluor. The resulting acyl fluoride, which is a versatile synthetic intermediate, was smoothly transformed into various carbonyl compounds, in particular, amides. This protocol can be applied to the chemoselective activation of diester compounds.
Abstract
A novel and unique activation method for esters possessing a non-activated cyclopropyl moiety as a potential activating group is developed for acyl fluoride generation using a hypervalent iodine(III) reagent and Selectfluor. The resulting acyl fluoride, which is a versatile synthetic intermediate, was smoothly transformed into the various carbonyl compounds, in particular, amides. This protocol can be applied to the chemoselective activation of diester compounds.
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