A one-pot multicomponent synthesis of a wide variety of highly functionalized 2, 4, 5-trisubstituted imidazole derivatives is reported using a variety of aldehydes, ammonium acetate, and benzil /benzoin in the presence of non-toxic, readily acces...
Artikel
CuCl2‐Catalyzed one‐step protocol for the synthesis of novel propargylamine analogs under ultrasound irradiation
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A rapid and simple method for the synthesis of novel highly functional propargylamine analogs with quinazoline building blocks and propargylamine scaffolds containing various cyclic amines in the presence of CuCl2 in DMF under ultrasound irradiation with good to excellent yields has been developed.
Abstract
In this work, twenty new polysubstituted propargylamine analogs were produced in good to excellent yields via one-step reaction of alkynes, aromatic aldehydes, and cyclic secondary amines using CuCl2 in DMF under ultrasound irradiation at 80 °C. Twelve compounds having both quinazoline building block and propargylamine scaffolds were synthesized.
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