The phytochemistry and bioactivity of the plant were studied. Isolation and validated LC-MS/MS analysis were conducted on the same extract. Potential limitations of chemical profiling such as compounds with the same molecular and fragment ions, a...
Artikel
Cross‐Coupling Reactions between Arenediazonium o‐Benzenedisulfonimides and Organolithium Reagents in a Deep Eutectic Solvent
Von Wiley-VCH zur Verfügung gestellt
The first examples of coupling of arenediazonium salts with organolithiums carried out under mild conditions and in deep eutectic solvents (based on glyceraol and KF) as a sustainable solvent system are described. A tentative hypothesis of the reaction mechanism is also proposed.
Abstract
A deep eutectic solvent (DES) based on glycerol and KF is successfully exploited as a solvent medium in cross-coupling reactions between arenediazonium o-benzenedisulfonimides and organolithium reagents (Muharashi-Feringa coupling). The reactions were carried out in open air and in mild conditions. The target products were obtained in fairly good yield (15 examples; average yield: 60 %). This is, on the best of our knowledge, the first example of Muharashi-Feringa coupling carried out with diazonium salts. A tentative hypothesis of the reaction mechanism was also proposed.
Zum VolltextÜberprüfung Ihres Anmeldestatus ...
Wenn Sie ein registrierter Benutzer sind, zeigen wir in Kürze den vollständigen Artikel.