Coupling of Heteroarene and Arenol via Nickel‐Catalyzed C−H/C−OH Activation

A nickel-catalyzed heteroarene C−H/arenol C−OH coupling reaction is reported, which omits the use of strong Lewis-acid additive and low atom-economy protecting reagent. Arrays of arenols and heteroarenes are effective in this protocol using the in-situ activating reagent pivalic anhydride.

Abstract

Increasing sustainability awareness throughout society has sought to bring more atom-economy and environmentally benign synthetic methods based on simultaneous reaction transformation through ubiquitous C−H and C−O activation. This work reports a Ni-catalyzed heteroarene C−H/arenol C−OH coupling reaction, which omits the use of strong Lewis-acid additive and low atom-economy protecting reagent. The array of arenols and heteroarenes is effective in this protocol using in-situ activating reagent of pivalic anhydride. Detailed mechanistic studies and identification of intermediate have been carried out to understand the nature of catalytic reactions.

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