![Synthesis of Substituted Pyrido[1,2‐a]benzimidazoles by Ruthenium‐Catalyzed C−H Bond Activation and Tandem Cyclization of 2‐Arylimidazo[1,2‐a]pyridines with Iodonium Ylides](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/3d43fdf8-0d2c-443c-9a99-640e00494500/ejoc202300684-toc-0001-m.png)
A ruthenium-catalyzed C−H bond activation and tandem cyclization of 2-arylimidazo[1,2-a]pyridines with iodonium ylides leading to pyrido[1,2-a]benzimidazole derivatives has been developed. This reaction is highly efficient over the ...
Artikel
Cobalt‐Catalyzed, 2‐Aminopyridine‐N‐Oxide‐Directed C(sp2)−H Bond Functionalization with Maleimides: Facile Access to Isoindolone Spirosuccinimides
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A straightforward method for the facile access of isoindolone spirosuccinimides has been developed through N,O-directing group-assisted, cobalt-catalyzed C−H functionalization of benzamides. Co-catalyzed C−H bond activation is the rate-determining step of this reaction.
Abstract
A cobalt-catalyzed, N,O-bidentate directing group-assisted C−H bond functionalization of benzamides with maleimides was developed for the facile access to isoindolone spirosuccinimides in good to excellent yields. This C−H bond activation and spirocyclization employing pyridine N-oxide as directing group provided very good substrate scope and tolerated various functional groups. Furthermore, the mechanistic investigation revealed that the C−H bond activation is the rate-determining step of this reaction.
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