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Biosynthesis of ZnO, Bi2O3 and ZnO−Bi2O3 bimetallic nanoparticles and their cytotoxic and antibacterial effects

ChemistryOpen, März 2024, DOI. Login für Volltextzugriff.

Von Wiley-VCH zur Verfügung gestellt

In this work, attempted to arrange synthesized Bi2O3, ZnO, ZnO−Bi2O3 nanoparticles by Biebersteinia Multifida extract and then their cytotoxicity and anti-bacterial investigate. This is a report on the synthesis and anticancer performance of synthesized samples on breast cancer cells (MCF-7), as well as their anti-bacterial activity against Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria.


This work introduces an easy method for producing Bi2O3, ZnO, ZnO-Bi2O3 nanoparticles (NPs) by Biebersteinia Multifida extract. Our products have been characterized through the outcomes which recorded with using powder X-ray diffractometry (PXRD), Raman, energy dispersive X-ray (EDX), field emission-scanning electron microscopy (FE-SEM), and Fourier-transform infrared (FT-IR) techniques. The finding of SEM presented porous structure and spherical morphology for Bi2O3 and ZnO NPs, respectively. While FE-SEM image of bimetallic nanoparticles showed both porous and spherical morphologies for them; so that spherical particles of ZnO have sat on the porous structure of Bi2O3 NPs. According to the PXRD results, the crystallite sizes of Bi2O3, ZnO and ZnO−Bi2O3 NPs have been obtained 57.69, 21.93, and 43.42 nm, respectively. Antibacterial performance of NPs has been studied on Staphylococcus epidermidis and Pseudomonas aeruginosa bacteria, to distinguish the minimum microbial inhibitory concentration (MIC). Antimicrobial outcomes have showed a better effect for ZnO-Bi2O3 NPs. Besides, wondering about the cytotoxic action against cancer cell lines, the MTT results have verified the intense cytotoxic function versus breast cancer cells (MCF-7). According to these observations, obtained products can prosper medical and biological applications.

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