Axial Chirality in Alkylidene‐Cyclic Molecules

Axially chiral alkylidenecycloalkanes and their related compounds are interesting molecules. Their axial chirality comes from the geometry of C=C double bond or the orientation of two substituents in the para position of cycloalkanes. This concept focuses on summarizing recent advances of axial chirality in alkylidene-cyclic molecules and arouse the research interests to this promising field.

Abstract

Axial chirality is an interesting stereoisomeric phenomenon in organic chemistry and a key structural feature of several organic compounds. Atropisomers such as biaryls, anilides and diaryl ethers are one type of axially chiral compounds, whose axial chirality is resulted from rotationally blocked single bond. Allenes, spiranes and alkylidenecycloalkanes are another type of axially chiral compounds and their axial chirality come from the perpendicular geometry of two pairs of substituents. The axial chirality in atropisomers, allenes and spiranes has been widely investigated and well developed, while the similar chirality in alkylidene-cyclic molecules gained very limited attentions. This concept focuses on summarizing recent advances of axial chirality in alkylidene-cyclic molecules and arouses the research interests to this promising field.

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