Asymmetric Ene‐Reduction by F420‐Dependent Oxidoreductases B (FDOR‐B) from Mycobacterium smegmatis

Asymmetric ene-reductions of FDOR-Bs against α,β-unsaturated compounds reveal a novel class of ene-reductases utilizing the uncommon cofactor F₄₂₀. Our study highlights the key role of Flavin/deazaflavin oxidoreductases B (FDOR-B) enzymes in acquiring stereocomplementarity with the Old Yellow Enzyme (OYE) family, leading to enhanced versatility of biocatalytic syntheses. The wider distribution of FDOR-Bs across bacterial genera compared to FDOR-A enzymes suggests a higher potential for identifying potent activity against industrially relevant substrates. More information can be found in the Research Article by S. W. Kang, C. J. Jackson et al.

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